A5072953369- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Tumors and Oncological Cases
- Cutaneous lymphoproliferative disorders research
- Oral and Maxillofacial Pathology
- Nonmelanoma Skin Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cancer and Skin Lesions
- Viral-associated cancers and disorders
- Bone Tumor Diagnosis and Treatments
- Cutaneous Melanoma Detection and Management
- Peptidase Inhibition and Analysis
- Management of metastatic bone disease
- Hedgehog Signaling Pathway Studies
- Cancer Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Colorectal and Anal Carcinomas
Fundación Instituto Valenciano de Oncología
2016-2025
Hospital General Universitario De Valencia
2019
Fundación Kovacs
2015
Hospital Universitario Puerta de Hierro Majadahonda
2012
Extra-skeletal Ewing sarcoma is a rare tumor, most commonly occurring in the paravertebral region, extremities, retroperitoneum, and very rarely visceral locations. We present two primary sarcomas confirmed at molecular level: one located stomach other bladder. Both tumors demonstrated strong diffuse membranous CD99 expression, accompanied by variable KIT immunoreactivity. Additionally, we provide review of literature on gastric bladder ES, including an analysis differential diagnoses for...
Breast implant‐associated anaplastic large cell lymphoma ( ALCL ) is a newly described clinical and pathologic entity that typically presents as seroma in the fibrous scar around implant. Less frequently, it solid peri‐implant mass, there have been no reports to date of cutaneous lesions presenting manifestation. We report case 56‐year‐old woman with history bilateral breast reconstruction following cancer right who consulted several papules on suggestive metastasis. Histopathology showed...
Although solitary fibrous tumors (SFTs) have an unpredictable evolution, some specific clinicopathologic factors been associated with the final outcome. We retrieved clinical, pathological and molecular data of 97 patients a histological diagnosis SFT Signal transducer activator transcription 6 (STAT6) positivity. retrospectively studied predictive recurrence/metastasis compared them clinical A wide immunohistochemical study analysis to detect NAB2/STAT6 gene fusion, tumor protein-53 (TP53)...
Primary breast lymphoma is a rare form of localized extranodal lymphoma, which affects the mammary glands unilaterally or bilaterally, and can also affect regional lymph nodes.We reviewed 55 patients, with disease stages IE IIE, diagnosed in 16 Spanish institutions between 1989 2016. A serial clinical variables treatment were collected, overall survival (OS) progression-free (PFS) calculated.Of 96.4% women an average age 69 years. total 53 patients corresponded to non-Hodgkin (NHL), whom...
Abstract HMGA1 is a structural epigenetic chromatin factor that has been associated with tumor progression and drug resistance. Here, we reported the prognostic/predictive value of for trabectedin in advanced soft-tissue sarcoma (STS) effect inhibiting or mTOR downstream pathway activity. The expression was assessed cohort 301 STS patients at mRNA (n = 133) protein level 272), by HTG EdgeSeq transcriptomics immunohistochemistry, respectively. silencing on activity gene profiling measured...
Relatively few studies have analyzed the mortality of follicular lymphoma (FL) patients in comparison with a sex- and age-matched general population. This study overall survival (OS) FL compared their expected population.Patients diagnosed were prospectively enrolled from 1980 to 2013. Standardized ratios (SMRs) obtained yearly age-specific rates Spain, OS was age- sex-matched population data.A total 1074 newly enrolled. The median 231 months (95% confidence interval [CI], 195-267 months)....
Primary breast lymphoma is a rare form of extra-nodal lymphoid neoplasm. The most common histological type the diffuse large B-cell lymphoma, which represents 60-80% all cases. Our study analyzes mutational profile primary through targeted massive sequencing with panel 38 genes in group 17 patients lymphoma. Seventy-point-five percent presented stage IE and 29.5% IIE. 44% cases correspond to lymphomas germinal center phenotype 33.3% activated B-cell. higher frequency include PIM1 (in 50%...
Primary cutaneous B-cell lymphomas (PCBCLs) are that can occur in the skin without evidence of extracutaneous involvement. The 2005 WHO/EORTC classification and its 2018 update have distinguished three main categories based on clinicopathological, immunohistochemical, genetic characteristics: primary marginal zone lymphoma (PCMZL), follicle centre (PCFCL), diffuse large lymphoma, leg type (PCDLBCL-LT). PCMZL PCFCL clinically indolent, while PCDLBCL-LT is an aggressive lymphoma. Due to low...
Follicular lymphoma is the second most common non-Hodgkin in United States and Europe. However, of prospective randomized studies have very little follow-up compared to long natural history disease. The primary aim this study was investigate long-term survival our series patients with follicular lymphoma.A total 1074 newly diagnosed FL were enrolled. Patients prospectively enrolled from 1980 2013.Median 54.9 months median overall over 20 years series. We analyzed who are still alive beyond...
Management of advanced cSCC is challenging, and many available systemic medications have modest efficacy. Cemiplimab has demonstrated efficacy in the treatment clinical trials, but real-world data are still limited. With objective evaluating cemiplimab a setting, we conducted prospective observational study 13 patients with cSCC. Six (46%) had locally disease, while 7 (54%) metastatic disease. A total 8 (62%) responded to cemiplimab. Five (38%) showed partial response, 3 (23%) complete...
Predictive biomarkers of trabectedin represent an unmet need in advanced soft-tissue sarcomas (STS). DNA damage repair (DDR) genes, involved homologous recombination or nucleotide excision repair, had been previously described as resistance sensitivity, respectively. The majority these studies only focused on specific factors (ERCC1, ERCC5, and BRCA1) did not evaluate several other DDR-related genes that could have a relevant role for efficacy. In this retrospective translational study, 118...