A5046969063- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Histiocytic Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Renal cell carcinoma treatment
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Dermatological and Skeletal Disorders
- Genetic and Kidney Cyst Diseases
- Tuberous Sclerosis Complex Research
- Cancer and Skin Lesions
- Lymphatic System and Diseases
- Renal and Vascular Pathologies
- Chronic Lymphocytic Leukemia Research
- Cardiac tumors and thrombi
- Renal and related cancers
- Kidney Stones and Urolithiasis Treatments
- Polyomavirus and related diseases
- Genetic factors in colorectal cancer
- Soft tissue tumors and treatment
- Genetic and rare skin diseases.
- Ovarian cancer diagnosis and treatment
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
Complejo Asistencial Universitario de Palencia
2012-2024
Hospital de León
2006-2023
Glostrup Hospital
2013
Hospital Valle del Nalón
2011
Anthrologica
2010
Boston Children's Hospital
1999
Harvard University
1999
Hospital Universitario Severo Ochoa
1995
Puigvert Foundation
1984-1986
Universitat Autònoma de Barcelona
1986
Summary Background The malignant mechanisms that control the development of cutaneous T-cell lymphoma (CTCL) are beginning to be identified. Recent evidence suggests disturbances in specific intracellular signalling pathways, such as RAS–mitogen-activated protein kinase, receptor (TCR)–phospholipase C gamma 1 (PLCG1)–nuclear factor activated T cells (NFAT) and Janus kinase (JAK)–signal transducer activator transcription (STAT), may play an essential role pathogenesis CTCL. Objectives To...
Abstract HMGA1 is a structural epigenetic chromatin factor that has been associated with tumor progression and drug resistance. Here, we reported the prognostic/predictive value of for trabectedin in advanced soft-tissue sarcoma (STS) effect inhibiting or mTOR downstream pathway activity. The expression was assessed cohort 301 STS patients at mRNA (n = 133) protein level 272), by HTG EdgeSeq transcriptomics immunohistochemistry, respectively. silencing on activity gene profiling measured...
No AccessJournal of UrologyPapers Presented at Annual Meeting the Section on Urology, American Academy Pediatrics; San Francisco, California; October 17-19, 1998: Stone Disease1 Sep 1999STAGHORN CALCULI IN CHILDREN: TREATMENT WITH MONOTHERAPY EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY A. ORSOLA, I. DIAZ, J. CAFFARATTI, F. IZQUIERDO, ALBEROLA, and J.M. GARAT ORSOLAA. ORSOLA , DIAZI. DIAZ CAFFARATTIJ. CAFFARATTI IZQUIERDOF. IZQUIERDO ALBEROLAJ. ALBEROLA GARATJ.M. View All Author...
Adamantinomas of the long bones are low-grade malignant tumours. They seem to be related osteofibrous dysplasia with a mesenchymal-to-epithelial transformation. We report case an adamantinoma revertant sarcomatoid transformation that showed complete loss epithelial differentiation. It corresponded 41-year-old male presented 8-cm multilobated lesion in centre distal tibia. On en bloc resection specimen, areas classic were found but most tumor high-grade neoplasm 2 histologic patterns: one...
Predictive biomarkers of trabectedin represent an unmet need in advanced soft-tissue sarcomas (STS). DNA damage repair (DDR) genes, involved homologous recombination or nucleotide excision repair, had been previously described as resistance sensitivity, respectively. The majority these studies only focused on specific factors (ERCC1, ERCC5, and BRCA1) did not evaluate several other DDR-related genes that could have a relevant role for efficacy. In this retrospective translational study, 118...
Granular cell tumors (GCT) are nerve sheath neoplasms composed of Schwann cells with granular cytoplasm. Perineurial the cellular component perineurium and perineuriomas, supposedly derived from perineurial cells. However, have also been found in other cell-derived tumors. These not well studied GCTs. We presence a series 24 GCTs EMA, claudin-1, Glut-1, which immunohistochemical markers for Three cases lacked fascicles. showed no proliferation (grade 0), 7 grade 1 proliferation, 11 2...
Objective: To validate the detection of human epidermal growth factor receptor-2 (HER2) status using Leica HER2 fluorescent in situ hybridization (FISH) system and subsequent semiquantitative analysis with Menarini Benelux D-Sight digital imaging platform, order to predict HER2-directed therapy patients invasive breast cancer.Method: assessment was performed on 328 formalin-fixed/ paraffine-embedded cancer tumours tissue microarrays (TMA) 100 (50 selected IHC++ 50 random IHC scores)...
Background and aim: We describe two cases of pseudoxanthomatous salpingitis (PXS), an uncommon entity, often unknown for clinicians pathologists. review the literature on this topic perform immunohistochemistry in order to study its pathogenesis. Methods: Both are studied by histochemical immnunohistochemical methods with a wide panel antibodies. Results: One case showed bilateral PXS, ovarian endometriosis adenomatoid tumor right tube. The second unilateral focus tubal endometriosis. first...
Abstract A case of superficial angiomyxoma arising in the areola a 49‐yr‐old woman is presented, including both fine‐needle aspiration cytology (FNAC) and histological study. The aspirate yielded rich myxoid background with isolated fusiform cells, showing oval, monomorphic nuclei minimal atypia. Sometimes these cells were arranged small fragments without any specific pattern. absence mitotic figures, atypia, or cutaneous breast epithelium suggested benign stromal neoplasm. final diagnosis...
11543 Background: Predictive biomarkers of trabectedin represent a clinical unmet need to support the rational selection this drug in advanced soft‐tissue sarcomas (STS) setting. A few potential predictive had been described previous studies, including ERCC1, BRCA1, and HMGA1, among others; however, they are based mostly on analysis single selected molecular factors. We presented here transcriptomic-based signature for efficacy STS. Methods: total 140 patients with STS (at diagnosis or at...