A5026069312- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Soft tissue tumors and treatment
- Vascular Tumors and Angiosarcomas
- Medical Imaging and Pathology Studies
- Radiopharmaceutical Chemistry and Applications
- Tuberous Sclerosis Complex Research
- Head and Neck Surgical Oncology
- Educational Innovations and Technology
- Polyomavirus and related diseases
- Fibroblast Growth Factor Research
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Educational Technology in Learning
- Cardiac tumors and thrombi
- Medical Imaging Techniques and Applications
- Oral and Maxillofacial Pathology
- Pulmonary Hypertension Research and Treatments
Hospital General Universitario Gregorio Marañón
2017-2024
Li-Fraumeni syndrome (LFS) is an autosomal dominant hereditary disease. It associated with the loss of function p53 protein and increased risk malignant tumor development at early age. The most frequently detected tumors include breast cancer, sarcomas, leukemia, brain tumors, adrenocortical carcinomas. While sarcomas account for only 1% solid they are more in these families.We report a simultaneous diagnosis hepatic perivascular epithelioid cell (PEComa), very rare subtype sarcoma, two...
Angiofibroma is a non-encapsulated, highly vascular tumor that usually originates in the nasopharynx. Laryngeal cases of extranasopharyngeal angiofibroma (ENA) are very rare pathology, especially children. Only eight ENA laryngeal have been described literature, and only one them pediatric case. In this report we present an 11-year-old child with epiglottic resected transoral endoscopic ultrasonic surgery (TOUSS) review literature. Because reccurrence after five months he underwent...
Clear cell sarcoma (CCS) is a rare and aggressive soft tissue sarcoma. CCS characterized by the translocation t(12;22) (q13;q12), involving fusion of EWSR1 ATF1 genes, less frequently gene EWSR1-CREB1. Usually, CCSs are considered poorly responsive to conventional chemotherapy. However, trabectedin has shown activity against translocation-related sarcomas. Furthermore, preclinical results suggest that promising antitumor agent for CCS, potentially inducing melanocytic differentiation.We...
11070 Background: The GMI is a marker of drug activity and represents an intra-patient comparison successive time to progression (TTP), defined as the TTP ratio between second (or later) line (TTPn) therapy divided by prior (TTPn−1). Defining clinical profile pts with >1.33 could help identify who can gain greater benefit from T. Methods: We retrospectively evaluated concordance efficacy outcomes profiles 198 ASTS treated trabectedin 1.5 mg/m² (24-h infusion q3w) 2 nd or further-line...
11543 Background: Predictive biomarkers of trabectedin represent a clinical unmet need to support the rational selection this drug in advanced soft‐tissue sarcomas (STS) setting. A few potential predictive had been described previous studies, including ERCC1, BRCA1, and HMGA1, among others; however, they are based mostly on analysis single selected molecular factors. We presented here transcriptomic-based signature for efficacy STS. Methods: total 140 patients with STS (at diagnosis or at...
Desmoid tumors are rare, benign, but locally aggressive fibromatoses that pose significant therapeutic challenges, particularly when located in the head and neck region. This report details case of an extensive cervical desmoid tumor dependent on levator scapulae muscle involving vertebral artery managed through surgical resection intraoperative navigation. A 45-year-old male presented with a slowly growing mass. Imaging revealed 83x68x40 mm mass right lateral paravertebral space, artery....
// Marta Arregui 1 , Antonio Calles María del Mar Galera Ana Gutiérrez Carlos López-Jiménez 2 Carolina Agra 3 Adriana Fernández 4 Natalia de Toro and Rosa Álvarez Department of Medical Oncology, Gregorio Marañón University Hospital, Madrid 28007, Spain Fundación Jiménez Díaz 28040, Pathology, Radiology, Correspondence to: López-Jiménez, email: clopezjimenez@atbsarc.org Keywords: malignant glomus tumor; glomangiosarcoma; BRAF V600E; agnostic treatment; targeted therapy Received: May 06, 2024...
(1) Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in first two decades of life. One third cases appear head and neck, with 60% these being embryonal type. RMS extremely rare adults, comprising only 1% adult malignancies, those, 3.3% are rhabdomyosarcomas. (2) Case report: A 46 y.o. male presented a 1 cm exophytic pediculated painless lesion on dorsum his tongue, progressive growth for 3 months. An excisional biopsy revealed an "embryonal rhabdomyosarcoma...
11071 Background: There are currently several second-line options for the treatment of ASTS as gemcitabine combinations, trabectedin, pazopanib, eribulin or olaratumab plus doxorubicin in cases where anthracyclins still possible. is an unmet need predictive biomarkers which hinders rational selection best sequence second line. We already published prognostic value FAS first line while this study analyzes its role different schemes. Methods: Most relevant criteria were having received...