A5010163161- Cutaneous lymphoproliferative disorders research
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Synthesis and Biological Evaluation
- Immune Cell Function and Interaction
- Computational Drug Discovery Methods
- CAR-T cell therapy research
- Phytochemical compounds biological activities
- 14-3-3 protein interactions
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Vascular Tumors and Angiosarcomas
- Melanoma and MAPK Pathways
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Chronic Disease Management Strategies
- Chronic Myeloid Leukemia Treatments
- Phosphodiesterase function and regulation
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Multiple Myeloma Research and Treatments
University of Oslo
2023-2025
Oslo University Hospital
2023-2025
Instituto de Investigación Marqués de Valdecilla
2015-2023
Universidad de Cantabria
2018-2023
Instituto de Biomedicina y Biotecnología de Cantabria
2018
ABSTRACT Regulatory T cells (Tregs) are a subset of defined by the expression Forkhead box protein P3 (FoxP3) playing crucial role in regulating effector cell activity. Tregs accumulate tumor microenvironment facilitating growth. Thus, targeting FoxP3 + could improve cancer immunotherapies. Here, we conducted high‐throughput, phenotypic screening drug repurposing library to identify compounds downregulating human primary cells. We identified tyrosine kinase inhibitor bosutinib and STAT3...
Summary Background The malignant mechanisms that control the development of cutaneous T-cell lymphoma (CTCL) are beginning to be identified. Recent evidence suggests disturbances in specific intracellular signalling pathways, such as RAS–mitogen-activated protein kinase, receptor (TCR)–phospholipase C gamma 1 (PLCG1)–nuclear factor activated T cells (NFAT) and Janus kinase (JAK)–signal transducer activator transcription (STAT), may play an essential role pathogenesis CTCL. Objectives To...
A better understanding of the molecular mechanisms that participate in development and clinical manifestations schizophrenia can lead to improve our ability diagnose treat this disease. Previous data strongly associated levels deregulated ADAMTS2 expression peripheral blood mononuclear cells (PBMCs) from patients at first episode psychosis (up) as well responders treatment with antipsychotic drugs (down). In current work, we performed an independent validation such studied implicated control...
Abstract Patients diagnosed with T-cell leukemias and lymphomas (TCLs) still have a poor prognosis an inadequate response to current therapies, highlighting the need for targeted treatments. We analyzed potential therapeutic value of farnesyltransferase inhibitor, tipifarnib, in 25 TCL cell lines through identification genomic and/or immunohistochemical markers tipifarnib sensitivity. More than half (60%) were considered be sensitive. Tipifarnib reduced viability these leukemia lines,...
// Susana Llerena 1, 2, * , Nuria García-Díaz 3, 4, Soraya Curiel-Olmo 3 Antonio Agraz-Doblas 5 Agustín García-Blanco 2 Helena Pisonero 4 María Varela 6 Miguel Santibáñez 7 Carmen Almaraz Laura Cereceda Nerea Martínez Teresa Arias-Loste Ángela Puente Luis Martín-Ramos Carlos Rodríguez de Lope Federico Castillo-Suescun 8 Cagigas-Fernandez Pablo Isidro 9 Lopez-López 10 Marcos Lopez-Hoyos 11 Javier Llorca 12, 13 Jesús Agüero 14 Benedicto Crespo-Facorro 15, 16 Ignacio Ángel Piris 17, ** Crespo...
Gene profiling using a customized NanoString platform can be applied to routine mycosis fungoides (MF) samples, revealing their specific molecular features. This study shows that MF samples carry signature derived from individual features found in consecutive biopsies.
Developing mechanistic rationales can improve the clinical management of cutaneous T-cell lymphomas. There is considerable genetic and biological evidence a malignant network signaling mechanisms, highly influenced by deregulated TCR/PLCγ1 activity, controlling biology these lesions. In addition, activated signal transducer activator transcription 3 associated with progression, although alterations responsible for this have not been fully elucidated. Here, we studied PLCγ1-dependent...
// Soraya Curiel-Olmo 1, * , Almudena García-Castaño 2, Rebeca Vidal 3, 4, 8 Helena Pisonero 1 Ignacio Varela 4 Alicia León-Castillo 5 Eugenio Trillo 6 Carmen González-Vela Nuria García-Diaz Almaraz Thaidy Moreno Laura Cereceda Madureira Nerea Martinez Pablo Ortiz-Romero 7 Elsa Valdizán Miguel Angel Piris 5, # José Pedro Vaqué Cancer Genomics Group, IDIVAL, Instituto de Investigación Marqués Valdecilla, Santander, Spain 2...
Introduction Cutaneous T Cell Lymphoma (CTCL) is a heterogeneous group of non-Hodgkin lymphomas with unfavourable prognosis at advanced stages. The malignant network that control the development CTCL now starting to be characterised. NGS-derived studies have identified multiple molecular alterations in specific genes and signalling pathways including PLCG1 JAK-STAT. It has been shown up 50% cases develop deregulated PLCG1-downstream as by activating mutations PRKCQ amplifications. Also,...
Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphomas. The diagnosis these patients is very challenging requires an integrated approach, incorporating clinical, morphological, immunophenotypic molecular features. substrate early advanced stages MF / SS still poorly understood and, consequently, treatment selection mainly based on clinical data. study aimed to transfer what known about pathogenesis diagnosis, prognosis, therapy by...