A5048289042- Dark Matter and Cosmic Phenomena
- Particle Detector Development and Performance
- Nonmelanoma Skin Cancer Studies
- Skin Diseases and Diabetes
- Cutaneous Melanoma Detection and Management
- Astrophysics and Cosmic Phenomena
- Cancer and Skin Lesions
- Autoimmune Bullous Skin Diseases
- Particle physics theoretical and experimental studies
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders
- Venous Thromboembolism Diagnosis and Management
- Cancer Diagnosis and Treatment
- Skin Protection and Aging
- Health, Environment, Cognitive Aging
- Vascular Tumors and Angiosarcomas
- Cutaneous lymphoproliferative disorders research
- Hedgehog Signaling Pathway Studies
- Eosinophilic Disorders and Syndromes
- Research on Leishmaniasis Studies
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Nail Diseases and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Melanoma and MAPK Pathways
Hospital Universitario Miguel Servet
2020-2025
Complexo Hospitalario Universitario A Coruña
2025
Universidad de Zaragoza
2013-2025
Instituto de Investigación Sanitaria Aragón
2023-2025
Fundación Instituto Valenciano de Oncología
2018-2022
Canfranc Underground Laboratory
2013-2015
Instituto de Astrofísica de Canarias
2013
A precision measurement by the Alpha Magnetic Spectrometer on International Space Station of positron fraction in primary cosmic rays energy range from 0.5 to 350 GeV based $6.8\ifmmode\times\else\texttimes\fi{}{10}^{6}$ and electron events is presented. The very accurate data show that steadily increasing 10 $\ensuremath{\sim}250\text{ }\text{ }\mathrm{GeV}$, but, 20 250 GeV, slope decreases an order magnitude. spectrum shows no fine structure, ratio observable anisotropy. Together, these...
The International Axion Observatory (IAXO) will be a forth generation axion helioscope. As its primary physics goal, IAXO look for axions or axion-like particles (ALPs) originating in the Sun via Primakoff conversion of solar plasma photons. In terms signal-to-noise ratio, about 4–5 orders magnitude more sensitive than CAST, currently most powerful helioscope, reaching sensitivity to axion-photon couplings down few × 10−12 GeV−1 and thus probing large fraction unexplored ALP parameter space....
UV radiation is the main etiological agent of skin cancer. Other factors such as pollution, diet and lifestyle are also contributing factors. Our aim was to investigate association between melanoma exposome in Spanish population with a prospective multicenter case-control study. Case group included patients while control people who attended consultations companions without past medical history A total 73 126 controls were included. The former more outdoor workers, cancer, drug use...
UV radiation is the main etiological agent of skin cancer. Other factors such as pollution, diet and lifestyle are also contributing factors. Our aim was to investigate association between melanoma exposome in Spanish population with a prospective multicenter case-control study. Case group included patients while control people who attended consultations companions without past medical history A total 73 126 controls were included. The former more outdoor workers, cancer, drug use...
The International Axion Observatory (IAXO) is a next generation axion helioscope aiming at sensitivity to the axion-photon coupling of few 10^{-12} GeV^{-1}, i.e. 1-1.5 orders magnitude beyond sensitivities achieved by currently most sensitive helioscope, CERN Solar Telescope (CAST). Crucial factors in improving for IAXO are increase magnetic field volume together with extensive use x-ray focusing optics and low background detectors, innovations already successfully tested CAST....
Introducción: El melanoma presenta una incidencia creciente en España. Los estadios pronósticos de los pacientes con son determinados por diversos factores biológicos, como el grosor del tumor, la ulceración o presencia metástasis regionales a distancia. La Academia Española Dermatología y Venereología (AEDV) ha impulsado creación un Registro Español Melanoma (REGESMEL) fin evaluar otros índole individual relacionados Sistema Sanitario que pudieran influir pronóstico melanoma. objetivo...
Micromegas detectors are an optimum technological choice for the detection of low energy x-rays. The background techniques applied to these yielded remarkable reductions over years, being CAST experiment beneficiary developments. In this document we report on latest upgrades towards further and better understanding detectors' response. encompass readout electronics, a new detector design implementation more efficient cosmic muon veto system. Background levels below 10−6keV-1cm-2s-1 have been...
Micromesh gas amplification structures (Micromegas) can be used as readout of Time Projection Chambers in the field Rare Event searches dealing with dark matter, double beta decay or solar axions. The topological information events offered by these gaseous detectors is a very powerful tool for signal identification and background rejection. However, this kind experiments radiopurity detector components surrounding materials must thoroughly controlled addition order to keep experimental low...
Small series of ultrasound findings in dermatofibrosarcoma protuberans (DFSP) have been published, but the usefulness this technique as a preoperative planning tool for tumor resection has not studied.We retrospectively reviewed patients with DFSP at our hospital that underwent examination. Depth invasion was evaluated by and histopathology. Accuracy assessing depth estimated.Thirty histopathologically confirmed DFSPs were studied. Classic finger-like projections observed 73.3% cases. A...
Management of advanced cSCC is challenging, and many available systemic medications have modest efficacy. Cemiplimab has demonstrated efficacy in the treatment clinical trials, but real-world data are still limited. With objective evaluating cemiplimab a setting, we conducted prospective observational study 13 patients with cSCC. Six (46%) had locally disease, while 7 (54%) metastatic disease. A total 8 (62%) responded to cemiplimab. Five (38%) showed partial response, 3 (23%) complete...
While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, most frequent form which basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate association BCC exposome-related Spanish population.
The International Axion Observatory (IAXO) is a new generation axion helioscope aiming at sensitivity to the axion-photon coupling of gaγ ≳ few × 10−12 GeV−1, i.e. 1–1.5 orders magnitude beyond one achieved by CAST, currently most sensitive helioscope. main elements IAXO are an increased magnetic field volume together with extensive use x-ray focusing optics and low background detectors, innovations already successfully tested in CAST. Additional physics cases could include detection...
The International Axion Observatory (IAXO) is a proposed 4th-generation axion helioscope with the primary physics research goal to search for solar axions via their Primakoff conversion into photons of 1 – 10 keV energies in strong magnetic field. IAXO will achieve sensitivity axion-photon coupling gaγ down few ×10−12 GeV−1 wide range masses up ∼ 0.25 eV. This an improvement over currently best (3rd generation) helioscope, CERN Solar Telescope (CAST), about 5 orders magnitude signal...
There are no large series describing cutaneous histologic changes during treatment with vismodegib in locally advanced basal cell carcinoma (BCC).To analyze skin biopsy specimens from patients BCC treated vismodegib.A descriptive, retrospective study of between June 2012 and December 2017 at the Instituto Valenciano de Oncología, Spain. Nineteen were biopsied before vismodegib, we compared observed.Seven (37%) achieved complete response, which was characterized by replacement tumor stroma a...
We model the response of a state art micro-hole single-stage charge amplication device (`microbulk' Micromegas) in gaseous atmosphere consisting Xenon/trimethylamine at various concentrations and pressures. The amplifying structure, made with photo-lithographic techniques similar to those followed fabrication gas electron multipliers (GEMs), consisted 100 um-side equilateral-triangle pattern 50 um-diameter holes placed its vertexes. Once primary electrons are guided into by virtue an...
Abstract Background While skin cancer awareness programs have significantly furthered public understanding about the harmful effects of sun, there is a disparity between photoprotection knowledge and protection practices. Objective To compare sun exposure habits measures in patients diagnosed with basal cell carcinoma (BCC), squamous (SCC), melanoma versus controls. Methods Multicentre case–control observational study carried out by 13 Spanish dermatologists April 2020 August 2022. Patients...
We have studied low-background techniques in order to improve the background level for Micromegas detectors. These detectors are good candidates rare event searches thanks low mass and radiopurity of materials used construction; moreover they discrimination capabilities. The motivation these studies is reduction CAST experiment where three four operating currently microbulk type. last result experience acquired has been by a factor 4.5 two experiment, corresponding an improvement 2 signal strength.
Management of advanced cSCC is challenging, and many available systemic medications have modest efficacy. Cemiplimab has demonstrated efficacy in the treatment clinical trials, but real-world data are still limited. With objective evaluating cemiplimab a setting, we conducted prospective observational study 13 patients with cSCC. Six (46%) had locally disease, while 7 (54%) metastatic disease. A total 8 (62%) responded to cemiplimab. Five (38%) showed partial response, 3 (23%) complete...
La necrobiosis lipoídica (NL) es una enfermedad granulomatosa crónica poco frecuente para la que existen multitud de tratamientos disponibles. No obstante, estos ofrecen habitualmente mínimos e inconsistentes resultados. En algunas publicaciones se describe el tratamiento con terapia fotodinámica (TFD) como segunda línea en casos refractarios, resultados variables. Comunicamos 4 NL tratados satisfactoriamente TFD convencional MAL y BF-200 ALA. Las pacientes eran mujeres afectas diabetes...