A5075775554- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Cancer Treatment and Pharmacology
- Gene expression and cancer classification
- Endometrial and Cervical Cancer Treatments
- Single-cell and spatial transcriptomics
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Immune cells in cancer
- Chemokine receptors and signaling
- Genomic variations and chromosomal abnormalities
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- CRISPR and Genetic Engineering
Hospital de Câncer de Barretos
2018-2024
Hospital São Paulo
2022
Early detection is crucial for achieving a reduction in breast cancer mortality. Analysis of circulating cell-free microRNAs present the serum patients has emerged as promising new noninvasive biomarker early tumors and predicting their molecular classifications. The rationale this study was to identify subtype-specific profiles serum. Fifty-four early-stage cancers with 27 age-matched controls were selected evaluation 54 cases molecularly classified (luminal A, luminal B, B Her2 positive,...
Esophageal squamous cell carcinoma (ESCC) is a common type of cancer characterized by fast progression and high mortality rates, which generally implies poor prognosis at time diagnosis. Intricate interaction networks cytokines produced resident inflammatory cells in the tumor microenvironment play crucial roles ESCC development metastasis, thus influencing therapy efficiency. As such, are most prominent targets for specific therapies prognostic parameters to predict aggressiveness. In this...
New prevention strategies are needed to detect cervical intraepithelial neoplasia (CIN). The microRNA expression analysis has already been reported as molecular biomarkers in the early detection of cancer (CC) through minimally invasive samples, such liquid biopsy, obtained collection using liquid-based cytology (LBC). In this study, we aimed identify signatures microRNAs precursor lesions from LBC and pathways potentially associated with CC progression. We analyzed 31 samples women who...
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA has frequently reported sporadic breast cancers, but few studies focused on profiling hereditary cancers. In this study, we aimed to identify specific signatures tumors compare with cancer normal tissues.Global using NanoString technology was performed 43 (15 BRCA1, 14 BRCA2, BRCAX), 23 8 tissues. These tissues...
This exploratory analysis of the Neoadjuvant Carboplatin in Triple Negative Breast Cancer (NACATRINE) study aimed to identify biomarkers pathological complete response (pCR) patients with triple-negative breast cancer (TNBC) treated neoadjuvant chemotherapy (NAC) within context a clinical trial. The NACATRINE trial is phase II, single-center, randomized, open-label that investigated addition carboplatin sequential anthracycline- and taxane-based NAC for TNBC. We evaluated gene expression...
Screening for cervical cancer by cytology has been effective in reducing the worldwide incidence and mortality rates of this disease. However, a number studies have demonstrated that sensitivity conventional may be too low detection intraepithelial neoplasias (CIN). Therefore, it is important to incorporate more sensitive molecular diagnostic tests could substantially improve accuracy identifying CIN lesions. MicroRNAs (miRNAs) are class small non-coding RNAs with potential provide robust...
MicroRNAs (miRNAs or miRs) play essential roles in the initiation and progression of human tumors, including cervical cancer. However, mechanisms underlying their actions cancer remain unclear. The present study aimed to evaluate functional role miR‑130a‑3p Cervical cells were transfected with a miRNA inhibitor (anti‑miR‑130a‑3p) negative control. Adhesion‑independent cell proliferation, migration invasion evaluated. findings presented herein demonstrated that was overexpressed HeLa, SiHa,...
Extracellular vesicles (EVs), ubiquitously released by blood cells, facilitate intercellular communication. In cancer, tumor-derived EVs profoundly affect the microenvironment, promoting tumor progression and raising risk of recurrence. These contain miRNAs (EV-miRNAs), promising cancer biomarkers. Characterizing plasma identifying EV-miRNAs associated with breast recurrence are crucial aspects research since they allow us to discover new biomarkers that effective for understanding biology...
Abstract In triple negative breast cancer (TNBC), achieving pathological complete response (pCR) is associated with improved survival outcomes. However, only one-third of patients receiving neoadjuvant chemotherapy (NAC) achieve pCR. Recognizing molecular markers that predict to and selecting who can benefit from NAC in clinical practice has been a challenge many studies. This exploratory analysis the NACATRINE trial aimed identify biomarkers pCR TNBC NAC. The Brazilian, phase II,...
Some studies reported that differential gene expression could be used as a biomarker for high-grade cervical lesion identification. The aim was to evaluate the profile of intraepithelial neoplasia (CIN) identify signature CIN2+ in liquid-based cytology (LBC) samples.
Liquid biopsy is increasingly vital in monitoring neoadjuvant breast cancer treatment. This study collected plasma samples at three time points from participants the Neoadjuvant Carboplatin Triple Negative Breast Cancer (NACATRINE), analyzing miRNA expression with NanoString's nCounter® Human v3 assay. In carboplatin arm, four ct-miRNAs exhibited dynamic changes linked to pathologic complete response, a combined area under curve of 0.811. Similarly, non-carboplatin arm featured an 0.843....
Introduction Breast cancer is the leading cause of death among women. The number human diagnosed with breast has been increased specially in middle and low countries. Early detection a key to reduce deaths. Biological fluids such as blood hold good opportunities identify new non-invasive biomarkers. One promising classes circulating biomarkers microRNAs (miRNAs). These molecules are tissue-specific, remarkably stable several biological samples have others intrinsic characteristics that make...
ABSTRACT Introduction Some studies have showing that cervical cytology is limited as a single method for the screening of cancer. In view this, it would be extremely important to incorporate molecular tests could improve accuracy detection precursor lesions. this scenario evaluation differential expression microRNAs (miRNAs) open window opportunities understand tumour onset and progression considering can used are good noninvasive biomarkers detected in liquid biopsy samples, such...