A5056329184- Corneal surgery and disorders
- Nonmelanoma Skin Cancer Studies
- Cervical Cancer and HPV Research
- Ocular Oncology and Treatments
- Ocular Infections and Treatments
- Corneal Surgery and Treatments
- Viral-associated cancers and disorders
- Glaucoma and retinal disorders
- Cancer Immunotherapy and Biomarkers
- Traumatic Ocular and Foreign Body Injuries
- DNA Repair Mechanisms
- Otitis Media and Relapsing Polychondritis
- Gynecological conditions and treatments
- Gestational Trophoblastic Disease Studies
- Ectopic Pregnancy Diagnosis and Management
- Reproductive tract infections research
- Renal and Vascular Pathologies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Female Genital Mutilation/Cutting Issues
- Colorectal and Anal Carcinomas
- Cerebral Venous Sinus Thrombosis
- Connective tissue disorders research
- Neurofibromatosis and Schwannoma Cases
- Tumors and Oncological Cases
- Autopsy Techniques and Outcomes
University of Lisbon
1997-2023
Centro Hospitalar Lisboa Norte
2010-2023
Hospital Garcia de Orta
2017-2023
Hospital de Santa Maria
2010-2023
Universidade Nova de Lisboa
1997
IntroductionThis study aimed to analyse cervical lymphocytic populations in HIV+ and HIV− patients correlate different lesions with HIV viral load presence of high-risk HPV types.Material methodsA total 132 histological specimens from 40 72 were evaluated for CD4+ CD8+ T cell distribution, types, peripheral blood CD4+/CD8+ ratio.ResultsHigh-grade squamous intraepithelial (HSIL) carcinoma (SCC) had lower scores compared patients. In all lesion groups, presented higher epithelial stromal...
Osteogenesis imperfecta (OI) is a rare inherited disease affecting collagen-rich tissues. Ocular complications have been reported such as thin corneas, low ocular rigidity, keratoconus, among others. The purpose of this study to characterize corneal tomographic features in OI patients compared unaffected patients, with particular focus on commonly studied keratoconus indices.Cross-sectional case-control including 37 and age-matched controls. Patients controls underwent comprehensive...
Abstract Programmed death-ligand 1 (PD-L1) is overexpressed in cervical carcinoma, hindering tumor destruction. The aim of this study was to assess PD-L1 expression by immunohistochemistry squamous cell carcinoma (SCC) and intraepithelial lesions (SILs) from human immunodeficiency virus–positive (HIV+) virus-negative (HIV-) patients. A total 166 SCC SIL samples HIV+ HIV- patients were included analyzed for through proportion score (TPS), results stratified five TPS groups using SP263...
Mucoepidermoid carcinoma is a rare variant of squamous cell the conjunctiva. It appears more frequently in elderly, it aggressive than carcinoma, and has higher recurrence rate incidence intraocular orbital invasion.We report case 74-year-old man who presented to Emergency Department with one month history painful red left eye.The patient visual acuity was 10/10 both eyes conjunctiva tumor on bulbar eye. The UBM revealed thickening conjunctiva-sclera complex no signs invasion. A biopsy...
Scleritis is a very uncommon manifestation in patients with IgA nephropathy. Here, we report the case of patient presenting diffuse anterior scleritis which laboratory disclosed microscopic haematuria and nephrotic range proteinuria. Renal function was normal. Serology for lupus, vasculitis cryoglobulinaemia negative. Rheumatoid factor negative, serum C3 C4 were on normal range. human immunodeficiency virus types 1 2, hepatitis B, C, syphilis, Lyme disease also A renal biopsy performed...
Müllerian anomalies are very common, and a frequent cause of infertility. The most used classification system until now, proposed by the American Society for Reproductive Medicine in 1988, categorizes comprehensively uterine but fails to classify defects cervix or vagina. This is based on developmental theory that postulates müllerian duct fusion unidirectional, beginning caudally extending cranially, which does not account isolated cervical vaginal defects. More recently, European Human...
Introduction and importance: Ocular Surface Squamous-cell Neoplasia (OSSN) is an infrequent diagnosis whose clinical suspicion assumes great importance should not be overlooked. The following case-report aims to describe the treatment of a patient with OSSN complaints were mild in comparison severity disease. chosen surgical technique was paramount for disease-free outcome while minimizing scarring effects removal.Patient presented discomfort right eye painless persistent hyperaemia....
Background: The curvature of the anterior corneal surface is traditionally used as a surrogate to estimate astigmatism. In recent years, increasing importance has been attributed posterior astigmatism an indicator. Our aim characterize in population with keratoconus and investigate its predictive value progression.Methods: Retrospective study from tertiary care centre (Hospital de Santa Maria, Lisbon, Portugal). Eighty-five patients (85 eyes) were included. All had two tomographical...
Abstract Objective Human immunodeficiency virus‐infected women have a high incidence of HPV infection, and HIV coinfection is associated with cervical intraepithelial lesions cancer. This study investigated the ability to detect mRNA in routine screening liquid‐based cytology (LBC) samples its correlation lesions. Methods Liquid‐based from 80 HIV‐infected under combined antiretroviral therapy (cART) were studied for detection using Aptima ® tests diagnosis according 2014 Bethesda System...
Introduction: To better understand the role of mucosa immunity in development cervical carcinoma HIV infection, lymphocyte subsets were characterized HIV+ and HIV− women, as well their relation to HPV-associated lesions. Methods: Eighty-three (52 HIV+, 31 HIV−) cell suspensions cervicovaginal lavage (CVL) 52 peripheral blood (PB) samples assessed by flow cytometry evaluate lymphoid populations. High-risk (HR) HPV was liquid-based cytology mRNA PB same patients. Results: Cervical CD4+ T cells...
Molar pregnancy, included in gestational trophoblastic disease, is a benign pathology with ability to metastasize, usually occurring excessively high βhCG levels. Clinical scenario woman extremes of reproductive age presenting amenorrhoea, pain and vaginal blood loss; signs derived from levels may be present (hyperthyroidism, hyperemesis). Diagnosis based on positive pregnancy test – qualitative urinary test. The limitation this results its inability become presence markedly βhCG, saturating...
Desmoid tumors are rare benign neoplasms, with locally aggressive characteristics. Ongoing or previous pregnancy, antecedent trauma, and familial adenomatous polyposis known risk factors. Still, the majority of cases sporadic its etiology is still unknown. These may occur in any body site, but retroperitoneal pelvic desmoid extremely rare. Nonspecific clinical radiological findings lead to erroneous diagnosis 50% patients before surgery. We present a case young multiparous female deep...