A5055732845- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Advancements in Semiconductor Devices and Circuit Design
- Acute Lymphoblastic Leukemia research
- Minimally Invasive Surgical Techniques
- Renal Transplantation Outcomes and Treatments
- Phagocytosis and Immune Regulation
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Acute Ischemic Stroke Management
- Case Reports on Hematomas
- Polyomavirus and related diseases
- Retinal Development and Disorders
- Thermal Regulation in Medicine
Hospital Universitario Virgen del Rocío
2015-2025
Instituto de Biomedicina de Sevilla
2014-2025
Universidad de Sevilla
2014-2025
Consejo Superior de Investigaciones Científicas
2023-2024
Ayuntamiento de Sevilla
2024
Centro de Investigación Biomédica en Red de Cáncer
2019-2024
Hospital Clínic de Barcelona
2005-2022
Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment based on use high doses corticosteroids. Unfortunately, second-line for both acute chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective safe option these patients. Seventy-nine patients received ruxolitinib were evaluated in this retrospective multicenter study. Twenty-three refractory median 3...
Bone marrow mononuclear cell (BM-MNC) intraarterial transplantation has emerged as a potential stroke therapy. We aimed to determine whether BM-MNC therapy induces changes in diffusion tensor imaging metrics of major white matter tracts. The IBIS trial was an investigator-initiated multicenter, phase IIb, randomized, controlled, assessor-blinded, clinical trial. Seventy-seven patients (aged 18-80 years) with nonlacunar middle cerebral artery ischemic within 1 7 days from onset and National...
Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as therapeutic options in treatment of chronic graft versus host disease (cGvHD). In this work, we aimed to determine if combined use both agents can exert a synergistic effect GvHD. For purpose, studied combination vitro GvHD mouse model. Our results show that favors ratio thymic cells conventional culture, without affecting suppressive capacity these Treg. The with Treg showed...
After reports on laparoendoscopic single-site (LESS) cholecystectomy, concerns have been raised over the level of difficulty and a potential increase in complications when moving away from conventional gold standard multiport laparoscopy due to incomplete exposure larger umbilical incisions. With continued development technique technology, it has now become possible fully replicate this procedure through an LESS approach. First experiences with newly developed instrument are reported.Fifteen...
Previous studies have shown the potential of microRNAs (miRNA) in pathological process stroke and functional recovery. Bone marrow mononuclear cell (BM-MNC) transplantation improves recovery experimental models ischemic that might be related with miRNA modifications. However, its effect on circulating has not been described patients stroke. We aimed to evaluate levels miRNAs after autologous BM-MNC investigate pattern miRNA-133b miRNA-34a expression included a multicenter randomized...
<title>Abstract</title> Ruxolitinib has been approved for the treatment of adults and pediatric patients ≥ 12 years with steroid refractory graft-versus-host disease (GvHD). However, real-life studies are needed to confirm results clinical trials further assess its efficacy in special populations. We performed a descriptive, retrospective, multi-centre study 352 42 treated ruxolitinib steroid-refractory acute or chronic GvHD. Among 119 233 adult GvHD, overall response rate (ORR) was 58.8%...
CAR therapy targeting BCMA is under investigation as treatment for multiple myeloma. However, given the lack of plateau in most studies, pursuing more effective alternatives imperative. We present preclinical and clinical validation a new optimized anti-BCMA (CARTemis-1). In addition, we explored how manufacturing process could impact CAR-T cell product quality fitness. CARTemis-1 optimizations were evaluated at level both, vitro vivo. generation was validated GMP conditions, studying...
Cellular cannibalism consists on the internalization of a cell into another same lineage. Internalized cells can maintain unaltered form (emperipolesis), suffer from degenerative passive changes, or be digested when receptor is phagocytic (phagocytosis). A six-year-old girl started with endocranial hypertension due to IV ventricle tumor complicated obstructive hydrocephalus. Tumor resection and placement ventriculoperitoneal shunt were accomplished. Histological diagnosis was established for...
Highlights•Waiting time to allogeneic hematopoietic stem cell transplantation was longer in acute myelogenous leukemia patients allocated an unrelated donor when compared with assigned a matched related donor.•Despite the delay associated allocation, similar proportion of failed reach both groups.•Transplantation outcomes were comparable among allocation groups.•No significant differences clinical from transplant approval observed.AbstractClinical after (allo-SCT) donors (URDs) approach...