A5103632942- Acute Ischemic Stroke Management
- Mesenchymal stem cell research
- Stroke Rehabilitation and Recovery
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cerebrovascular and Carotid Artery Diseases
- Management of metastatic bone disease
- Nutritional Studies and Diet
- Atrial Fibrillation Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Ultrasound and Hyperthermia Applications
- Sodium Intake and Health
- Mathematical Biology Tumor Growth
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Dye analysis and toxicity
- Cardiovascular Health and Disease Prevention
- Polyomavirus and related diseases
- Multiple Sclerosis Research Studies
- Diabetic Foot Ulcer Assessment and Management
- Musculoskeletal pain and rehabilitation
- Biochemical Analysis and Sensing Techniques
- Microtubule and mitosis dynamics
- Wound Healing and Treatments
- Neurological Disorders and Treatments
Hospital Universitario Virgen del Rocío
2013-2025
Fundación Kovacs
2013-2015
Hospital Quirónsalud Sagrado Corazón
2004
Bone marrow mononuclear cell (BM-MNC) intra-arterial transplantation improves recovery in experimental models of ischemic stroke. We aimed to assess the safety, feasibility, and biological effects autologous BM-MNC patients with stroke.A single-blind (outcomes assessor) controlled Phase I/II trial was conducted middle cerebral artery Autologous BM-MNCs were injected intra-arterially between 5 9 days after Follow-up done for up 6 months blood samples collected markers. The primary outcome...
Rationale No neuroprotective or neurorestorative therapies have been approved for ischemic stroke. Bone marrow mononuclear cell intra-arterial transplantation improves recovery in experimental models of Aims This trial aims to test safety and efficacy injection autologous bone stroke patients. Design Multicenter, prospective, phase II, randomized, controlled (non-treated group as control), assessor-blinded clinical trial. Seventy-six patients will be enrolled. Patients fulfilling...
Bone marrow mononuclear cell (BM-MNC) intraarterial transplantation has emerged as a potential stroke therapy. We aimed to determine whether BM-MNC therapy induces changes in diffusion tensor imaging metrics of major white matter tracts. The IBIS trial was an investigator-initiated multicenter, phase IIb, randomized, controlled, assessor-blinded, clinical trial. Seventy-seven patients (aged 18-80 years) with nonlacunar middle cerebral artery ischemic within 1 7 days from onset and National...
Bone marrow mononuclear cell (BM-MNC) intra-arterial transplantation improves recovery in experimental models of ischemic stroke through secretion cytokines and growth factors (GFs), enhancing neoangiogenesis, neuroplasticity. In this study, we tested whether BM-MNC patients induces changes serum levels GFs. A phase I/II trial was conducted middle cerebral artery (MCA) with autologous between 5 9 days after stroke. Follow-up done for up to 6 months. Eight cases nine controls were included,...
Background and Purpose. BM‐MNC transplantation improves recovery in experimental models of ischemic stroke. Clinical trials are ongoing to test efficacy stroke patients. However, whether cell dose is related outcomes not known. Methods . We performed a pooling data analysis two pilot clinical with autologous BM‐MNCs Cell route were analyzed evaluate their relation good outcome (m‐Rankin scale [mRS] score 0–2) at 6 months. Results Twenty‐two patients included. A median 153 × 10 (±121 ) was...
Low-grade gliomas are primary brain tumors that arise from glial cells and usually treated with temozolomide (TMZ) as a chemotherapeutic option. They often incurable, but patients have prolonged survival. One of the shortcomings treatment is eventually develop drug resistance. Recent findings show persisters, enter dormancy state to resist treatment, play an important role in development resistance TMZ. In this study we constructed mathematical model low-grade glioma response TMZ...
What currently appears to be irreversible axonal loss in normal appearing white matter, measured by proton magnetic resonance spectroscopy is of great interest the study Multiple Sclerosis. Our aim determine damage matter and correlate this with functional disability Sclerosis Functional Composite scale, Neurological Rating Scale, Ambulation Index Expanded Disability Scale Score. Thirty one patients (9 male 22 female) relapsing remitting a Kurtzke Score 0–5.5 were recruited from four...
We aimed to assess baseline inter-hemispheric perfusion differences, before carotid artery stenting (CAS), of severe internal (ICA) stenosis, and evaluate changes over time after CAS by means weighted imaging (PWI).Dynamic susceptibility contrast PWI was performed in 33 patients with ICA stenosis 1 day CAS, repeated 23 30 days CAS. Cerebral blood volume, cerebral flow, arrival (T0), mean transit time, peak (TTP) relative values comparing symptomatic asymptomatic hemispheres were obtained....
Objective: To evaluate by MR diffusion weighted image (DWI-MR) the presence of new ischemic cerebral lesions after carotid artery stenting (CAS) and distal protection, in patients with internal (ICA) stenosis >70. Methods: Sixty-seven CAS were performed under protection a filter. Mean age was 68.3 years (range 37–86) 42 (62.7%) symptomatic. An EZ filter device used all cases. The mean length procedure 22.2 minutes 8–110). All had MRI done 3 days before DW-MR (eco planar single shot, b= 1000...
Background and Aims: The benefits of Mediterranean Diet (MeDiet) in prevention cardiovascular diseases (CVD) general ischemic stroke (IS) have been extensively studied reported. We hypothesize that the consumption nutrients typical MeDiet would also reduce rate silent brain infarcts (SBI) among AF patients. Methods Results: Patients with a history who scored 0 to 1 CHADS2 score, ⩾50 years absence neurological symptoms were selected from Seville urban area using Andalusian electronic...