A5037834270- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Pleural and Pulmonary Diseases
- Ubiquitin and proteasome pathways
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Occupational and environmental lung diseases
- Single-cell and spatial transcriptomics
- Protein Degradation and Inhibitors
- Head and Neck Cancer Studies
Biomedical Research Institute of Lleida
2022-2024
Universitat de Lleida
2024
Karolinska Institutet
2022
Karolinska University Hospital
2022
Human papillomavirus positive (HPV+) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) have a favorable outcome, but upon relapse, survival is poor new therapeutical options are needed. Recently, we found synergistic effects by combining the food drug administration approved (FDA) phosphoinositide 3-kinase (PI3K) fibroblast-growth-factor-receptor (FGFR) inhibitors BYL719 JNJ-42756493 on TSCC lines. Here this approach was extended Cyclin-Dependent-Kinase-4/6 (CDK4/6)...
The sensitivity of pleural fluid (PF) analyses for the diagnosis malignant effusions (MPEs) is low to moderate. Knowledge about pathobiology and molecular characteristics this condition limited. In study, crosstalk between stromal cells tumor was investigated in vitro order reveal factors that are present PF which can mediate MPE formation aid discriminating benign etiologies. Eighteen samples, different proportions, were exposed mesothelial MeT-5A determine biological effects on these...