A5030889201- Hippo pathway signaling and YAP/TAZ
- Carbon Dioxide Capture Technologies
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Cancer Cells and Metastasis
- Membrane Separation and Gas Transport
- Membrane-based Ion Separation Techniques
- Chemical Looping and Thermochemical Processes
- Developmental Biology and Gene Regulation
- Membrane Separation Technologies
- Insect symbiosis and bacterial influences
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Fuel Cells and Related Materials
- Wnt/β-catenin signaling in development and cancer
- Digestive system and related health
- Plant Surface Properties and Treatments
- Corrosion Behavior and Inhibition
- Layered Double Hydroxides Synthesis and Applications
- Adsorption, diffusion, and thermodynamic properties of materials
- Industrial Gas Emission Control
- Calcium Carbonate Crystallization and Inhibition
- Advanced Fluorescence Microscopy Techniques
- Microgrid Control and Optimization
- Covalent Organic Framework Applications
University of Sheffield
2018-2024
Imperial College London
2015-2019
Institut de Biologia Molecular de Barcelona
2010-2018
Institute for Research in Biomedicine
2010-2018
University of Cambridge
2009
Metastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to lack models vivo. Here we show that expression EMT master inducer Snail primary adult Drosophila intestinal tumors leads dissemination tumor cells and formation macrometastases. drives an cells, which, although retaining some epithelial markers, subsequently break through basal lamina midgut, undergo a collective migration seed polyclonal metastases. While metastases re-epithelialize...
Abstract Coconut husks and shells are underutilised agricultural feedstocks in the bio-based industry. These biomass wastes have a higher lignin content than other woody excellent potential as raw materials for production of lignin-based materials. This work demonstrates performance low-cost protic ionic liquid, N,N,N -dimethylbutylammonium hydrogen sulfate ([DMBA][HSO 4 ]), ionoSolv pretreatment coconut husk shell at 150 °C 45–90 min 170 15–60 min. Optimum conditions were observed 45 both...
Chemical looping processes based on multiple-step reduction and oxidation of metal oxides hold great promise for a variety energy applications, such as CO
The apicobasal polarity of epithelia depends on the integrated activity apical and basolateral proteins, is essential for tissue integrity body homeostasis. Yet these tissues are frequently move as they sculpted by active morphogenetic cell rearrangements. How does survive stresses? We analyse this question in renal tubules Drosophila, a that undergoes dramatic change it develops. Here we show that, whereas Bazooka Scribble protein groups required establishment tubule polarity, key...
Whereas the series of genetic events leading to colorectal cancer (CRC) have been well established, precise functions that these alterations play in tumor progression and how they disrupt intestinal homeostasis remain poorly characterized. Activation Wnt/Wg signaling pathway by a mutation gene APC is most common trigger for CRC, inducing benign lesions progress carcinomas due accumulation other alterations. Among those, Ras mutations drive tumour as epithelial cancers. As mammalian...
Abstract Collective cell migration is a key process underlying the morphogenesis of many organs as well tumour invasion, which very often involves heterogeneous populations. Here we investigated how such populations can migrate cohesively in Drosophila posterior midgut, comprised epithelial and mesenchymal cells show novel role for adhesion molecule E-cadherin (E-Cad) cells. Despite lack junctions at ultrastructure level, reducing E-Cad levels causes to detach from one another neighbouring...
As the global water crisis worsens and natural resources of strategic inorganic elements dwindle, need for efficient effective salt separation methods is becoming ever more important. Electromembrane processes, in particular electrodialysis, are emerging as technologies that use an electric field to drive transport ions against a concentration gradient. Modelling electromembrane processes allows process design optimisation, well identification what technological improvements would have...
Mesenchymal-to-epithelial transition (MET) converts cells from migratory mesenchymal to polarized epithelial states. Despite its importance for both normal and pathological processes, very little is known about the regulation of MET in vivo. Here we exploit midgut morphogenesis Drosophila melanogaster investigate mechanisms underlying MET. We show that down-regulation EMT transcription factor Serpent required MET, but not sufficient, as interactions with surrounding mesoderm are also...
The intercalation of mesenchymal cells into epithelia, through mesenchymal-to-epithelial transition (MET), underlies organogenesis, for example, in nephrogenesis, and tissue regeneration, during cell renewal wound repair. Despite its importance, surprisingly little is known about the mechanisms that bring MET comparison with related much-studied, reverse process, epithelial-to-mesenchymal (EMT). We analyse molecular events regulate as stellate integrate established epithelium developing...
Several transcription factors have been identified that activate an epithelial-to-mesenchymal transition (EMT), which endows cells with the capacity to break through basement membranes and migrate away from their site of origin. A key program in development, recent years it has shown be a crucial driver tumour invasion metastasis. However, several these EMT-inducing are often expressed long before initiation invasion-metastasis cascade as well non-invasive tumours. Increasing evidence...
Foaming of amine solutions remains a problem for natural gas sweetening and post-combustion carbon capture. New amine-based are being developed to replace monoethanolamine (MEA). This work tested the foaminess MEA three alternatives (methyldiethanolamine (MDEA), 1-(2-aminoethyl)piperazine (AEPZ), 2-amino-2-methyl-1-propanol (AMP)) before after thermal degradation; two methods were used describe foaminess. Foam was only formed degradation. The first method suggests foaminess, where AEPZ >...
Surface crystallization of calcium sulfate was investigated using a dissipation crystal quartz microbalance (QCM-D) together with microscopy to understand the mechanical property changes occurring during growth process. The use optical and SEM revealed that needle-shaped crystals grow as clusters on QCM sensor's surface, not in uniform layers. As progressed, QCM-D inversions between negative positive frequency shifts. This behavior, function clusters, is adequately predicted by existing...