A5020399391- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Marine Ecology and Invasive Species
- Planarian Biology and Electrostimulation
- Insect symbiosis and bacterial influences
- Evolution and Genetic Dynamics
- Insect behavior and control techniques
- Genetics, Aging, and Longevity in Model Organisms
- Hedgehog Signaling Pathway Studies
- CRISPR and Genetic Engineering
- Insect and Arachnid Ecology and Behavior
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
- Genetic and Kidney Cyst Diseases
- Wnt/β-catenin signaling in development and cancer
- Liver Disease and Transplantation
- dental development and anomalies
- Aquaculture disease management and microbiota
- Protein Kinase Regulation and GTPase Signaling
- Chromosomal and Genetic Variations
- Insect Utilization and Effects
- Neurological diseases and metabolism
- Retinoids in leukemia and cellular processes
Biomedical Research Institute of Lleida
2018-2023
Universitat de Lleida
2020-2023
Institute for Research in Biomedicine
2009-2018
Institut de Biologia Molecular de Barcelona
2001-2014
Howard Hughes Medical Institute
2004
Universitat de Barcelona
1995-1998
Centre d’Investigació i Desenvolupament
1998
Metastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to lack models vivo. Here we show that expression EMT master inducer Snail primary adult Drosophila intestinal tumors leads dissemination tumor cells and formation macrometastases. drives an cells, which, although retaining some epithelial markers, subsequently break through basal lamina midgut, undergo a collective migration seed polyclonal metastases. While metastases re-epithelialize...
Whereas the series of genetic events leading to colorectal cancer (CRC) have been well established, precise functions that these alterations play in tumor progression and how they disrupt intestinal homeostasis remain poorly characterized. Activation Wnt/Wg signaling pathway by a mutation gene APC is most common trigger for CRC, inducing benign lesions progress carcinomas due accumulation other alterations. Among those, Ras mutations drive tumour as epithelial cancers. As mammalian...
Organ and tissue formation requires a finely tuned temporal spatial regulation of differentiation programmes. This is necessary to balance sufficient plasticity undergo morphogenesis with the acquisition mature traits needed for physiological activity. Here we addressed this issue by analysing deposition chitinous extracellular matrix Drosophila, an essential element cuticle (skin) respiratory system (tracheae) in insect. Chitin activity chitin synthase Krotzkopf verkehrt (Kkv). Our data...
The influence of oncogenic phenomena on the ecology and evolution animal species is becoming an important research topic. Similar to host-pathogen interactions, cancer negatively affects host fitness, which should lead selection control mechanisms, including behavioral traits that best minimize proliferation malignant cells. Social behavior suggested tumor progression. While ecological benefits sociality in gregarious are widely acknowledged, only limited data available role social...
Several DNA sequences similar to the mariner element were isolated and characterized in platyhelminthe Dugesia (Girardia) tigrina. They 1,288 bp long, flanked by two 32 bp-inverted repeats, contained a single 339 amino acid open-reading frame (ORF) encoding transposase. The number of copies this is approximately 8,000 per haploid genome, constituting member middle-repetitive Sequence analysis several elements showed high percentage conservation between different copies. Most them presented...
The evolutionary perspective of cancer (which origins and dynamics result from processes) has gained significant international recognition over the past decade generated a wave enthusiasm among researchers. In this context, several authors proposed that insights into adaptation cancers can be by studying strategies organisms. Although reasoning is fundamentally correct, in our opinion, it contains potential risk excessive adaptationism, potentially leading to suggestion complex adaptations...
Hormones play essential roles during development and maintaining homeostasis in adult organisms, regulating a plethora of biological processes. Generally, hormones are secreted by glands perform systemic action. Here we show that Juvenile (JHs), insect sesquiterpenoids synthesized the corpora allata, also Drosophila gut. This local, gut specific JH activity, is acts on intestinal stem cell enteroblast populations, their survival cellular growth through receptors Gce/Met coactivator Tai....
Hosts often accelerate their reproductive effort in response to a parasitic infection, especially when chances of future reproduction decrease with time from the onset infection. Because malignancies usually reduce survival, and hence potentially fitness, it is expected that hosts early cancer could have evolved adjust life-history traits maximize immediate effort. Despite potential importance these plastic responses, little attention has been devoted explore how cancers influence animal...
ABSTRACT Regulated activation of receptor tyrosine kinases depends on both the presence receptors at cell surface and availability their ligands. In Drosophila, torso kinase is distributed along embryo but it only activated poles by a diffusible extracellular ligand generated each pole that trapped receptor, thereby impeding further diffusion. Although known this signal activity several genes, such as torso-like trunk, still unclear how generated. The identification responsible for an...
Metastasis is the leading cause of colorectal cancer (CRC)-related deaths. Therefore, identification accurate biomarkers predictive metastasis needed to better stratify high-risk patients provide preferred management and reduce mortality. In this study, we identified 13 new genes that modified circulating tumor cell numbers using a genome-wide genetic screen in whole animal CRC model. Candidate were subsequently evaluated at gene expression level both an internal human cohort 153 independent...
A self-regulating receptor allows cells to maintain the appropriate balance of ligand-bound and unbound receptors.
Drosophila melanogaster (Drosophila) models of cancer are emerging as powerful tools to investigate the basic mechanisms underlying tumour progression and identify novel therapeutics. Rapid inexpensive, it is possible carry out genetic drug screens at a far larger scale than in vertebrate organisms. Such whole-organism-based permits assessment absorption toxicity, reducing possibility false positives. Activating mutations Wnt Ras signalling pathways common many epithelial cancers, when...