A5041958200- Genetics, Aging, and Longevity in Model Organisms
- Invertebrate Immune Response Mechanisms
- Adipose Tissue and Metabolism
- Neurobiology and Insect Physiology Research
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Physiological and biochemical adaptations
- Metabolism and Genetic Disorders
- Spaceflight effects on biology
- Pancreatic function and diabetes
- Biochemical Acid Research Studies
- Silk-based biomaterials and applications
- Epigenetics and DNA Methylation
- Renal and related cancers
- Heat shock proteins research
- CRISPR and Genetic Engineering
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Circadian rhythm and melatonin
- Studies on Chitinases and Chitosanases
Universidad Pablo de Olavide
2023-2025
Universidad de Sevilla
2023-2025
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2023-2025
University College London
2019-2024
University of Glasgow
2019
MRC Unit for Lifelong Health and Ageing
2019
University of Tübingen
2015
Organ and tissue formation requires a finely tuned temporal spatial regulation of differentiation programmes. This is necessary to balance sufficient plasticity undergo morphogenesis with the acquisition mature traits needed for physiological activity. Here we addressed this issue by analysing deposition chitinous extracellular matrix Drosophila, an essential element cuticle (skin) respiratory system (tracheae) in insect. Chitin activity chitin synthase Krotzkopf verkehrt (Kkv). Our data...
Neurodegenerative diseases are characterized by the localized loss of neurons. Why cell death is triggered only in specific neuronal populations and whether it response to toxic insults or initial cellular state that determines their vulnerability unknown. To understand individual responses disease, we profiled transcriptional signatures throughout disease development a Drosophila model C9orf72 (G4C2) repeat expansion (C9), most common genetic cause frontotemporal dementia amyotrophic...
Abstract ATP-citrate lyase is a central integrator of cellular metabolism in the interface protein, carbohydrate, and lipid metabolism. The physiological consequences as well molecular mechanisms orchestrating response to long-term pharmacologically induced Acly inhibition are unknown. We report here that inhibitor SB-204990 improves metabolic health physical strength wild-type mice when fed with high-fat diet, while healthy diet results imbalance moderated insulin resistance. By applying...
Health and survival in old age can be improved by changes gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task to generate pre-ribosomal (rRNA). We find that reducing levels of Pol activity sufficient extend lifespan fruit fly. This effect recapitulated partial, adult-restricted inhibition, with both enterocytes stem cells adult midgut emerging as important cell types. In cells, appears act same longevity pathway III, implicating rRNA synthesis these key...
Highlights•Xbp1s triggers distinct transcriptional profiles in the gut and fat body•Xbp1s can extend lifespan independently from both tissues•Fat body Xbp1 is essential for dFOXO-induced extension•Overexpressing unspliceable Xbp1U extends Drosophila lifespanSummaryTranscription factors reprogram gene expression to promote longevity. Here, we investigate role of Xbp1. activated by splicing its primary transcript, Xbp1u, generate Xbp1s, a key activator endoplasmic reticulum unfolded protein...
ABSTRACT The GATA family of transcription factors is implicated in numerous developmental and physiological processes metazoans. In Drosophila melanogaster, five different factor genes (pannier, serpent, grain, GATAd GATAe) have been reported as essential the development identity multiple tissues, including midgut, heart brain. Here, we present a novel role for GATAe function homeostasis renal (Malpighian) tubule. We demonstrate that reduced levels gene expression tubule principal cells...