A5075291360- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- AI in cancer detection
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Neuroendocrine Tumor Research Advances
- Hair Growth and Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Reproductive tract infections research
- Lung Cancer Research Studies
- Ovarian cancer diagnosis and treatment
- Helicobacter pylori-related gastroenterology studies
- Cancer and Skin Lesions
- Reproductive System and Pregnancy
- melanin and skin pigmentation
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
- Pregnancy and preeclampsia studies
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Gynecological conditions and treatments
National and Kapodistrian University of Athens
2016-2024
University General Hospital Attikon
2017-2022
General University Hospital of Patras
2015
Agios Andreas Hospital
2008-2012
Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cancer (ICC) is crucial for understanding the natural history HPV-infected lesions potential impact HPV vaccination on prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled two parallel cross-sectional studies (108288/108290). Centralised histopathology review standardised HPV-DNA typing applied to...
Cancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell population in the tumour microenvironment, serving diverse functions progression. However, mechanisms via which CAFs influence anti-tumour immunity remain poorly understood. Here, using multiple models and biopsies from cancer patients, we report that α-SMA
Cervical glandular neoplasias (CGN) present a challenge for cervical cancer prevention due to their complex histopathology and difficulties in detecting preinvasive stages with current screening practices. Reports of human papillomavirus (HPV) prevalence type-distribution CGN vary, providing uncertain evidence support prophylactic vaccination HPV screening. This study [108288/108290] assessed women diagnosed adenocarcinoma situ (AIS, N = 49), adenosquamous carcinoma (ASC, 104), various...
Abstract Calcified chondroid mesenchymal neoplasm is a recently recognized bone and soft tissue entity primarily found in the extremities temporomandibular joint. This typically driven by fusion of FN1 gene with kinase. In this case report, we provide detailed account rare superficial calcified located on left big toe, characterized an FN1::FGFR2 fusion. The tumor exhibited peripheral collarette consisted large intradermal histiocytoid to epithelioid cells no mitotic activity. These...
Background: BRAF mutations are a common finding in malignant melanoma (MM). Nevertheless, apart from their significance as therapeutic target advanced melanoma, prognostic value is still debated.Objective: To assess mutation status primary, recurrent, or metastatic MM and its correlations with histopathological findings.Methods: We analyzed 203 samples 178 consecutive patients: 129 primary cutaneous MM, 49 recurrent of unknown site, 25 cases recurrences metastases MM. exon 15 were identified...
Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial characterized by progressive band-like recession of the frontotemporal hairline and frequent loss eyebrows. It predominantly affects postmenopausal women. Coexistence FFA vitiligo rarely reported in literature. We retrospectively studied 20 cases diagnosed with 14-month period our Department. Among them, there were 2 cases, 72-year-old woman 48-year-old man, who developed on preexisting forehead. Anatomical colocalization...
Dermoscopic features of cutaneous squamous cell carcinoma (cSCC) have been widely studied, but their accuracy should be further investigated.This study assessed the diagnostic a set predetermined dermoscopic structures for 3 variants cSCC, namely Bowen disease, keratoacanthoma and invasive cSCC.Dermoscopic images 56 histopathologically confirmed cSCC lesions (9 disease lesions, 7 keratoacanthomas, 40 cSCCs) were examined, was assessed. Discriminative ability statistically significant...
There have been various attempts to assess endometrial lesions on cytological material obtained via direct sampling. The majority of efforts focus the description criteria that lead classification systems resembling histological reporting formats. These low reproducibility, especially in cases atypical hyperplasia and well differentiated carcinomas. Moreover, they are not linked implied risk malignancy.The was collected from women examined at outpatient department four participating...
A carcinoid tumor of the pancreas (CTP) is a rare pancreatic neoplasm, and usually presents with syndrome (CS). CS consists classic symptom triad cutaneous flushing, diarrhea valvular disease, occurs in majority patients liver metastases. In present study, patient presented symptoms CS. diagnosis CTP was suspected due to high levels urine 5-hydroxyindolacetic acid, this confirmed by fine-needle aspiration biopsy. Computed tomography showed extended lymphadenopathy, but no The managed...
Duodenal gangliocytic paragangliomas are rare neoplasms often arising in proximity to the major duodenal papilla of Vater. These considered have a benign behavior with lymph node metastases being phenomenon and distant metastatic disease even more so. Resection tumor is only definitive therapy.A 67year old male presented referring hospital symptoms fatigue malaise. Evaluation CT imaging revealed 3.1cm intraluminal mass situated grossly at junction third fourth portion duodenum. The was found...
The present report describes the case of an 81‑year‑old woman who underwent emergency explorative laparotomy due to small bowel perforation. Diffuse feculent peritonitis perforation jejunum was identified. In addition, six distinct tumors in close proximity site, as well two more lesions caudally at ileum, were A separate stenotic tumor identified sigmoid colon, causing moderate dilatation whole intestine. An enterectomy, including site and proximal tumors, performed, followed by limited...
Aim of this article is to investigate the potential Artificial Intelligence (AI) in discrimination between benign and malignant endometrial nuclei lesions. For purpose, 416 histologically confirmed liquid-based cytological smears were collected morphometric characteristics cell measured via image analysis. Then, 50% cases used train an AI system, specifically a learning vector quantization (LVQ) neural network. As result, classified as or malignant. Data from remaining evaluate system...
Background: Human Papilloma Virus has been considered as the main cause for cervical cancer. In this study we investigated epigenetic changes and especially methylation of specific sites HPV genome. The goal was to correlate status with histological grade well determine its accuracy in predicting disease severity by establishing optimum cutoffs. Methods: total, sections from 145 cases genotyped HPV16 were obtained formalin- fixed, paraffin-embedded tissue biopsies, conization or hysterectomy...
Objective of this study is to investigate the potential an artificial intelligence (AI) technique, based on competitive learning, for discrimination benign from malignant endometrial nuclei and lesions. For purpose, 416 liquid-based cytological smears with histological confirmation were collected, each smear corresponded one patient. From was extracted nuclear morphometric features by application image analysis system. Subsequently measurement 50% cases used train AI system classify...
Introduction We evaluated the effect of Helicobacter pylori (HP) eradication on p53, cyclin D1 expression, and cell proliferation in gastric mucosa. Materials Methods assessed D1, ki67 immunoexpression mucosa from 31 HP chronic gastritis patients 12 controls. Reassessment was performed 6 months after successful eradication. Results Successful resulted significant decrease p53 (1.53 ± 0.16 vs 0.83 0.19, P = 0.01) (9.84 0.96 4.77 0.27, < 0.001) staining antrum. Similarly, immunoreactivity...
Basal cell carcinoma (BCC) quite frequently presents as multiple tumors in individual patients. Neoplasm's risk factors for local recurrence have a critical impact on therapeutic management. To detect BCCs (mBCC) patients and to describe clinical dermatoscopic features of low- high-risk tumors. Our study included 225 with 304 surgically excised primary BCCs. All patients' medical history demographics were recorded. Clinical images evaluated predefined criteria statistical analyses performed....
Basosquamous carcinoma (BSC) is a relatively rare type of neoplasm originating from basal cell with features squamous differentiation. BSC has an aggressive local behaviour tendency for recurrence and less frequent metastatic potential The primary objective was to describe the dermatoscopic tumour. Secondary goals were detect morphological tumour along patients' characteristics evaluate possible histopathological correlations Twenty-two patients 25 BSCs enrolled. All tumours surgically...
Generalized bullous fixed drug eruption (GBFDE) is a specific variant of that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis based mainly on clinical course especially the reoccurrence typical lesions in previous new sites after re-administration offending drug. We present well-documented case fluconazole-induced GBFDE, with positive patch test fluconazole (30% weight/volume preparation) tolerance itraconazole proven by negative oral provocation. Even SCARs, testing...