A5052010650- Air Quality and Health Impacts
- Noise Effects and Management
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Climate Change and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Cervical Cancer and HPV Research
- Multiple Sclerosis Research Studies
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Genital Health and Disease
- Endometrial and Cervical Cancer Treatments
- Vehicle Noise and Vibration Control
- Advanced Breast Cancer Therapies
- Respiratory and Cough-Related Research
- HER2/EGFR in Cancer Research
- Air Quality Monitoring and Forecasting
- Lung Cancer Research Studies
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Smoking Behavior and Cessation
- Magnesium in Health and Disease
- Topic Modeling
Karolinska Institutet
2009-2025
Daiichi Sankyo (Germany)
2022-2025
Daiichi-Sankyo (South Korea)
2022
IQ Samhällsbyggnad
2019-2021
IQVIA (United Kingdom)
2017-2018
GlaxoSmithKline (Belgium)
2011-2013
GlaxoSmithKline (United Kingdom)
2011
Stockholm County Council
1998-2009
Azienda Sanitaria Locale Roma 3
2007-2008
Environmental Health
2001
An association has been reported between long-term exposure to road traffic noise and the risk of myocardial infarction (MI), but evidence is limited inconclusive. No previous study simultaneously analyzed role air pollution from in MI.A population-based case-control on MI was conducted 1992-1994 Stockholm County. Participants answered a questionnaire underwent physical examination. Residential 1970 assessed for 3666 participants (1571 cases 2095 controls), based residential history combined...
Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cancer (ICC) is crucial for understanding the natural history HPV-infected lesions potential impact HPV vaccination on prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled two parallel cross-sectional studies (108288/108290). Centralised histopathology review standardised HPV-DNA typing applied to...
Background: It has been suggested that noise exposure increases the risk of hypertension. Road traffic is dominant source community exposure. Objective: To study association between to residential road and hypertension in an urban municipality. Methods: The population comprised randomly selected subjects aged 19–80 years. A postal questionnaire provided information on individual characteristics, including diagnosis response rate was 77%, resulting a 667 subjects. outdoor equivalent level...
Cervical glandular neoplasias (CGN) present a challenge for cervical cancer prevention due to their complex histopathology and difficulties in detecting preinvasive stages with current screening practices. Reports of human papillomavirus (HPV) prevalence type-distribution CGN vary, providing uncertain evidence support prophylactic vaccination HPV screening. This study [108288/108290] assessed women diagnosed adenocarcinoma situ (AIS, N = 49), adenosquamous carcinoma (ASC, 104), various...
In the DESTINY-Breast03 clinical trial, trastuzumab deruxtecan (T-DXd) showed superior progression-free survival and overall versus emtansine (T-DM1) manageable safety in patients with human epidermal growth factor receptor 2 (HER2)-positive (HER2+) metastatic breast cancer. Here, patient-reported outcomes (PROs) are reported along hospitalization data.Patients were assessed for prespecified PRO measures, including European Organization Research Treatment of Cancer quality life (EORTC-QoL)...
To investigate whether there is a relation between residential exposure to aircraft noise and hypertension.The study population comprised two random samples of subjects aged 19-80 years, one including 266 residents in the vicinity Stockholm Arlanda airport, another comprising 2693 inhabitants other parts county. The were classified according time weighted equal energy maximum levels at their residence. A questionnaire provided information on individual characteristics history prevalence odds...
Cohort studies have reported increased risks of cardiopulmonary mortality from long-term air pollution exposure, but the evidence is limited and inconclusive. We studied association between exposure to source-specific myocardial infarction (MI) in a case-control study first-time MI cases population controls age 45 70 years Stockholm county 1992 1994.Home addresses during several decades were combined with historical emission databases dispersion models obtain annual mean levels pollutants...
An association between aircraft noise exposure and hypertension prevalence has been suggested but there are no longitudinal studies of this association. Our aim was to investigate the influence on incidence hypertension.A cohort 2754 men in 4 municipalities around Stockholm Arlanda airport followed 1992-1994 2002-2004. The based Diabetes Preventive Program; half study subjects had a family history diabetes. Residential (expressed as time-weighted equal energy maximal levels) assessed by...
Urban air pollution can trigger asthma exacerbations, but the effects of long-term exposure to traffic-related on lung function or onset airway disease and allergic sensitisation in children is less clear.All 2107 aged 9-14 years from 40 schools Rome 2000-1 were included a cross-sectional survey. Respiratory symptoms assessed 1760 by parental questionnaires (response rate 83.5%). Allergic was measured skin prick tests spirometry 1359 (77.2%). Three indicators assessed: self-reported heavy...
Exposure to elevated levels of ambient air pollutants can lead adverse cardiovascular effects. Potential mechanisms include systemic inflammation and perturbation the coagulation balance.To investigate long- short-term effects pollution exposure on serum inflammatory (IL-6, TNF-alpha CRP) (fibrinogen PAI-1) markers relevant for pathology.The study group consisted a population sample 1028 men 508 women aged 45-70 years from Stockholm. Long-term was assessed using spatial modelling...
Background: Long-term air pollution exposure is associated with increased mortality, but the association incidence of fatal and nonfatal coronary heart disease less certain. Moreover, it unknown how chronic to affects prognosis among survivors a first event. This study evaluated between long-term traffic-related events, as well subsequent hospital readmission mortality myocardial infarction survivors. Methods: The population comprised all residents Rome aged 35–84 years during period...
BackgroundMultiple sclerosis (MS) patients have an increased risk of infections, but few population-based studies reported infections occurring in MS the years immediately after diagnosis.ObjectiveTo explore incident MS, stratified by age and sex.MethodsIn a Swedish cohort study 6602 (aged ≥18 years), matched at diagnosis with 61,828 MS-free individuals were identified between 1st January 2008 31st December 2016, using national registers. Incidence rates (IR) incidence rate ratios (IRR) 95%...
Background: Although long-term air pollution exposure has been linked to cardiovascular mortality, data on incidence and nonfatal coronary disease are limited inconclusive. The aim of this study was investigate the association between residential from traffic risk fatal myocardial infarction. Methods: records all individuals aged 15 79 with a first event infarction in Stockholm County during 1985 1996 were retrieved registry. Population controls randomly selected base stratified by age, sex,...
Objective: To estimate the cost of dementia care and its relation to dependence. Method: Disease severity health resource utilization was retrieved from Swedish National Study on Aging Care. Informal assessed with Resource Utilization in Dementia instrument. A path model investigates relationship between annual dependence, cognitive ability, functioning, neuropsychiatric symptoms, comorbidities. Results: Average among patients diagnosed €43,259, primarily incurred by accommodation. use, that...
Background: The electronic medical record (EMR) offers unique possibilities for clinical research, but some important patient attributes are not readily available due to its unstructured properties. We applied text mining using machine learning enable automatic classification of information on smoking status from Swedish EMR data. Methods: Data patients' EMRs were used develop 32 different predictive models that trained Weka, changing sentence frequency, classifier type, tokenization, and...
A decreased risk for cardiovascular disease has been related to the hardness of drinking water, particularly high levels magnesium. However, evidence is still uncertain, especially in relation individual intake from water.We used data Stockholm Heart Epidemiology Program, a population-based case-control study conducted during 1992-1994, association between myocardial infarction and daily water magnesium calcium. Our analyses are based on 497 cases age 45-70 years, 677 controls matched age,...
Acute otitis media (AOM) not only affects childhood quality of life (QoL), but can also affect parental QoL. We adapted a previously published questionnaire on the effect recurrent ear, nose and throat infections QoL for use with AOM used it in an observational, multicentre, prospective study children AOM.The AOM-specific grouped 15 items into emotional, daily disturbance, total overall impact scores. The was assessed using item-convergent item-discriminant validity criteria internal...
With the introduction of investigational human epidermal growth factor receptor 2 (HER2) targeting treatments, thorough understanding breast cancer with different HER2 expression levels is critical. The aim this study was to compare clinicopathologic characteristics and survival patients metastatic according level expression.Women distant during 2008-2016 were selected from PALGA, Dutch Pathology Registry, linked PHARMO Database Network. Breast samples categorised as immunohistochemistry...