A5015960449- Reproductive System and Pregnancy
- Ovarian function and disorders
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Reproductive Biology and Fertility
- Gynecological conditions and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Uterine Myomas and Treatments
- Adipose Tissue and Metabolism
- Food Industry and Aquatic Biology
- Pregnancy and Medication Impact
- Apelin-related biomedical research
- Endometriosis Research and Treatment
- Mitochondrial Function and Pathology
- Gestational Diabetes Research and Management
- Diagnosis and treatment of tuberculosis
- Pelvic and Acetabular Injuries
- Pregnancy and preeclampsia studies
- Nutrition, Genetics, and Disease
- Hormonal and reproductive studies
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2020-2025
Institute of Evolutionary Physiology and Biochemistry
2018-2022
Drug delivery systems enhance drug efficacy while minimizing side effects. Liposomes, as well-studied and clinically approved carriers, offer biodegradability, biocompatibility, low toxicity, making them suitable for delivering various pharmacological agents. Granulocyte colony-stimulating factor (G-CSF), a key growth factor, has shown therapeutic potential, particularly in infertility treatment. It effectively manages chronic refractory endometritis by improving endometrial receptivity...
The effectiveness of the use a modified intrauterine gel form granulocyte colony stimulating factor in complex treatment Ascherman syndrome is evaluated. study involved 31 patients with history syndrome. For 6 months, underwent weekly administration 1 ml concentration 9 million IU/ml using an catheter. Monthly M-echo was evaluated on 19th–22nd day menstrual cycle, as well volume blood loss according to Pictorial Blood Loss Assessment Chart. After completed, control hysteroscopy performed....
BACKGROUND: The effectiveness of in vitro fertilization cycles / frozen-thawed embryo transfer depends on a number factors, the endometrial one being great importance. Adequate and subendometrial blood supply is considered necessary for successful implantation. Currently, possibilities non-invasive assessment implantation properties endometrium are limited to use ultrasound. AIM: aim this study was assess performance three-dimensional power Doppler angiography combined with Virtual Organ...
BACKGROUND: The adipokines leptin, adiponectin, and ghrelin are expressed not only in adipose tissue but also the hypothalamic-pituitary-gonadal axis organs uterus. They regulate gonadotropin-releasing hormone gonadotropin secretion, steroidogenesis, folliculogenesis, implantation, serve as promising markers of assisted reproductive technology program outcomes. AIM: aim this study was to evaluate dynamics blood adipokine levels their ratios during controlled ovarian hyperstimulation programs...
Objective. To determine the correlation between fatty acid (FA) levels in follicular fluid (FF) and outcomes of assisted reproductive technology (ART) programs depending on body mass index (BMI). Patients methods. A total 120 patients with infertility undergoing ART protocols were divided into three groups: normal BMI (group 1; n = 40), overweight 2; obesity 3; 40). FA FF evaluated by MALDI spectrometry. Results. Pregnant group 2 had lower myristic (p 0.008). 3 stearic 0.03) higher...
Adipokines are involved in the regulation of female reproductive system. The purpose was to study possibility using adipokines levels follicular fluid predict IVF efficiency.Four groups women were studied: pregnant during IVF, with normal (PN, n = 9) and increased (BMI > 25 kg/m2) body weight (BW) (PI, 7), nonpregnant (nPN, 16) BW (nPI, 21).In PN group, leptin level higher than nPN group (p < .05). In PI nPI groups, it did not differ, but BW. ghrelin lower .05), while comparable....
BACKGROUND: Cell therapy is a promising trend in treating characterized by inflammation and sclerosis diseases such as genital tuberculosis, marked pelvic inflammatory disease uterine tube occlusion.
 AIM: Efficacy evaluation of combined mesenchymal stem cells specific polychemotherapy treatment the experimental tuberculosis.
 MATERIALS AND METHODS: Chinchilla rabbits (n = 27) were divided on 4 groups. Group 1 6) comprised control group, healthy animals. 2 7) infected with without...
Adiponectin is the most important adipokine controlling food behavior and energy homeostasis. At present, there much evidence that adiponectin also regulates functions of reproductive system, its targets are hypothalamic neurons responsible for synthesis secretion gonadoliberin, pituitary gonadotrophs producing luteinizing hormone, gonads. In target tissues, which blocks hypothalamic-pituitary-gonadal axis, all main components adiponectin-regulated signaling including both types receptors,...
Abstract Study question Can the adipokines levels and ratios in follicular fluid (FF) be used to predict vitro fertilization (IVF) outcomes? Summary answer The leptin level leptin/ghrelin leptin/adiponectin FF are reliable prognostic factors for IVF outcomes women with normal body mass index (BMI). What is known already adipose tissue serves not a simple fat storage, rather an important endocrine organ, producing adipokines, such as leptin, adiponectin, ghrelin others. Adipokines have been...