A5056905163- Cervical Cancer and HPV Research
- Genital Health and Disease
- Reproductive Health and Contraception
- Metabolomics and Mass Spectrometry Studies
- Healthcare Systems and Public Health
- Molecular Biology Techniques and Applications
- Reproductive tract infections research
- Herpesvirus Infections and Treatments
- Pharmacological Effects of Natural Compounds
- Maternal and fetal healthcare
- Urological Disorders and Treatments
- Parvovirus B19 Infection Studies
- Pelvic floor disorders treatments
- Reproductive System and Pregnancy
- Ginseng Biological Effects and Applications
- Fungal Infections and Studies
- Natural product bioactivities and synthesis
- Pediatric health and respiratory diseases
- AI in cancer detection
- Toxin Mechanisms and Immunotoxins
- Hepatitis Viruses Studies and Epidemiology
- Medical and Biological Ozone Research
- T-cell and Retrovirus Studies
- Ectopic Pregnancy Diagnosis and Management
- Phytoestrogen effects and research
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
1993-2024
Ministry of Health of the Russian Federation
1993-2021
Aim. To analyze the literature data on relationship between vaginal microbiota and gynecological diseases, including HPV-associated diseases. Key points. The is key factor influencing women’s reproductive health. In a healthy microbiota, lactobacilli dominate, not only preventing colonization of pathogenic microorganisms but also helping to maintain integrity cervical mucosa. Conclusion. A shift in toward increasing leads dysbiosis, which may contribute inflammation, increased risk...
Cervicovaginal fluid (CVF) is a valuable source of clinical information about the female reproductive tract in both nonpregnant and pregnant women. The aim this study to specify CVF proteome at different stages cervix neoplastic transformation by label-free quantitation approach based on liquid chromatography tandem mass spectrometry (LC-MS/MS) method. composition from 40 women age with human papillomavirus (HPV)-associated (low-grade squamous intraepithelial lesion [LSIL], high-grade...
Abstract The mass spectrometry‐based molecular profiling can be used for better differentiation between normal and cancer tissues the detection of neoplastic transformation, which is great importance diagnostics a pathology, prognosis its evolution trend, development treatment strategy. aim present study evaluation tissue classification approaches based on various data sets derived from profile organic solvent extracts tissue. A set possibilities are considered orthogonal projections to...
Individual sexual and reproductive life management has been сonfirmed by medical state communities since 1990s. Every citizen officially received rights for access to appropriate goods services. Such international agreements as 1994 International Conference on Population Development (ICPD, Cairo, Egypt) 2004 WHO Reproductive health strategy, estimated family planning priorities. Worldwide agreement the 2005 summit declares achieving of female before year 2015 worldwide progress. created...
Introduction. Pregnancy planning is one of the leading areas in population reproductive health care, particular preventing and reducing number abortions. Aim. To evaluate uterine bleeding profile other adverse events associated with use an etonogestrel subcutaneous contraceptive implant (Implanon NXT®). Materials methods. We analysed medical records female patients (n = 153) who used Implanon NXT® period from 2013 to 2023, events, bleeding, management techniques reasons given by women for...
A dramatic increase in cervical diseases associated with human papillomaviruses (HPV) women of reproductive age has been observed over the past decades. An accurate differential diagnosis severity intraepithelial neoplasia and choice optimal treatment requires search for effective biomarkers high diagnostic prognostic value. The objective this study was to introduce a method rapid shotgun lipidomics differentiate stages HPV-associated cervix epithelium transformation. Tissue samples from 110...
Among gynaecological diseases in women of reproductive age the leading place is occupied by inflammatory lower part genital tract (70%), a significant proportion which are processes vagina and cervix uteri. In ⅔ women, cervicitis most often asymptomatic, so they do not seek medical treatment, 65–77.6% have transition to chronic form. Thus, diagnosed almost one three who assistance from gynaecologist due leukorrhea, there no tendency for decrease frequency. The article presents an actual view...
The role of human papillomavirus (HPV) in the development cervical cancer and other diseases anogenital area has been proven well known. Despite this, incidence is growing every year. Specific methods HPV treatment are not developed, only effective method prevention to prevent infection itself. A number randomized clinical trials have demonstrated extremely high (up 100%) effectiveness vaccines. Currently, vaccine approved by WHO included National Immunization Program 86 countries, 17...
Genital herpes (GH) is top-ranked in the sexually transmitted infection (STIs) rating, which associated with a lifelong persistence of virus infected patients, polymorphism clinical manifestations infection, high percentage relapsing forms disease progression. Combination therapy local use activated glycyrrhizic acid-containing drug contributes to reducing duration GH relapse, more rapid healing skin and mucosal lesions, increasing remission period. A patient can plan pregnancy absence...
Vulvar lichen sclerosus (VLS) is a dermatosis characterized by lymphocytic reaction and genital skin lesions that significantly affects the quality of life. Due to limited efficacy, current treatment options require further improvement in terms new understanding etiopathogenetic mechanisms long-lasting recurrent course disease. Objective. To compare efficacy safety monotherapy with glucocorticosteroids (GCs) combination therapy GCs Superlimf® cream (lanolin vitamin-mineral protein-peptide...
Cervical cancer is one of the most common cancers in women with pronounced stages precancerous lesions. Accurate differential diagnosis such lesions primary challenges medical specialists, which vital to improving patient survival. The aim this study was develop and test an algorithm for cervical based on lipid levels scrapings from epithelium cervicovaginal canal. composition samples analyzed by high-performance chromato-mass spectrometry. Lipid markers were selected using Mann-Whitney a...
The burden of persistent papillomavirus infection on public healthcare is not limited to cervical cancer (CC). At present, continues be one the most common types worldwide, although HPV also causes anogenital warts. As there no treatment available, nowadays researchers focus search for new therapeutic platforms, agents HPV-associated diseases relapse prevention after surgical treatment. Significant anticancer effects resveratrol have been demonstrated in a variety cancers, including breast...
Human papillomavirus infection in women and men causes benign, premalignant malignant diseases of the anogenital area. Laboratory diagnosis plays a major role early detection HPV-associated women, but there are no approved screening modalities, which can detect men. Examination sexual partners patients with HPV is substantiated important link chain cancer prevention methods.
The review examined the role of HPV in anogenital diseases. There are presented modern data on prevalence anal intraepithelial neoplasia (AIN), infection region among women at risk (cervical - CIN, vulvar VIN, vaginal VaIN). considered methods diagnosis HPV-associated Analyzes literature importance development screening AIN patientswith VaIN. preliminary results research patients with genital neo-plasias, different tropism to cervical epithelium and region.
Analysis of the results several studies has shown a correlation between human papillomavirus (HPV) infection and bacterial vaginosis (BV), more frequent persistence HPV its recurrence until occurrence HPV-associated diseases. Susceptibility to tropism local immunity's ability eliminate can be changed under influence number adverse factors. One these factors is which gives balanced ecosystem vagina defense mechanisms against other infections
The review examines a role of HPV in the development pre-cancer and cancer anogenital region. It presents current data on incidence cervical (CIN) anal intraepithelial neoplasia (AIN), infection region women at risk (CIN, VIN, VaIN). Methods for diagnosis HPV-associated diseases are considered. article reviews literature importance AIN screening patients with CIN, VaIN. also provides results own studies neoplasias, trophicity to epithelium canal Type 16 is dominant type CIN anus. diseases,...
Timely and reasonable selection of methods contraception after childbirth from the standpoint safety for mother child, in addition to preventing unwanted pregnancy, preserves reproductive health woman. When choosing a method postpartum period, it is necessary take into account impact on lactation, condition child. Prenatal counseling allows increase commitment women selected contraception.
HPV infects epithelial tissues regardless of their location and penetrates into the cell through microscopic cuts. The clinical manifestations HPV-associated diseases are diverse equally relevant for women men. Despite fact that exophytic condylomas regarded as a benign disease establishing diagnosis does not cause difficulties, clinician should always have oncological alertness, especially with regard to diffuse, long-lasting condylomatosis.
If abnormal cytology test results are identified in the users of hormonal methods contraception, including a vaginal ring, they should adhere to diagnostic algorithms aimed at identifying and treating HPV-associated cervical diseases. NovaRing ring is an effective, reliable safe method for women who have previously undergone surgical treatment HSIL.
Human papillomavirus (HPV) is one of the main pathogens genital tract infections, which can lead to malignant transformation cells cervix, vagina, vulva and anus. Approximately 90% cervical intraepithelial neoplasia cases 99% cancer occur in HPV-positive patients. However, presence HPV patients body not be considered as a marker progression or regression pathological process. The need determine further tactics examination management women with HPV-associated diseases cervix States search for...
In 2020, the Russian Federation at national level adopted amendments to Federal Law of 06.10.2003, №131-FZ “On general principles local self-government”, regulating issues participatory budgeting. That was an important step in development citizens, commercial and non-profit organizations participation practices government. Nowadays Russia there is a contradictory tendency: state itself initiates supports for involving population self-government, but, demonstrate reluctance authorities...
The review article presents data on the prevalence of candidiasis various localization against history coronavirus infection (COVID-19). predisposing factors for development and recurrence in patients after therapy have been analysed. Candida is one most common pathogens intensive care units (ICUs), affecting 6 to 10% patients, some studies reported an increasing trend candidemia. literature that we analysed showed types fungal among with a severe course COVID-19 were C. albicans, then...