A5075697004- Tryptophan and brain disorders
- Immune Response and Inflammation
- Stress Responses and Cortisol
- COVID-19 Clinical Research Studies
- Human Health and Disease
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Pediatric health and respiratory diseases
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Effects of Radiation Exposure
- S100 Proteins and Annexins
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Toxin Mechanisms and Immunotoxins
- Long-Term Effects of COVID-19
- Sinusitis and nasal conditions
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Viral Infections and Immunology Research
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Neutropenia and Cancer Infections
- Sodium Intake and Health
- Asthma and respiratory diseases
State Research Institute of Highly Pure Biopreparations
2016-2025
Czech Academy of Sciences, Institute of Experimental Medicine
2017-2024
Saint Petersburg Pasteur Institute
2023-2024
First Pavlov State Medical University of St. Petersburg
2022-2024
Institut Pasteur
2022
Federal Medical-Biological Agency
2009-2020
National Research Mordovia State University
2019
Institute of Experimental Medicine
2019
Cytokinetics (United States)
2019
Krasnoyarsk State Medical University
2018
Background Levels of marinobufagenin (MBG), an endogenous bufadienolide Na/K-ATPase (NKA) inhibitor, increase in preeclampsia and NaCl-sensitive hypertension. Methods We tested a 3E9 monoclonal anti-MBG antibody (mAb) for the ability to lower blood pressure (BP) hypertension reverse preeclampsia-induced inhibition erythrocyte NKA. Measurements MBG were performed via immunoassay based on 4G4 mAb. Results In hypertensive Dahl-S rats, intraperitoneal administration 50 μg/kg mAb lowered BP by 32...
In 2023, the pandemic of new coronavirus infection caused by SARS-CoV-2 was declared over WHO. Apparently, has become a seasonal respiratory viral infection. Among problems remaining after end pandemic, one leading places is occupied post-Covid syndrome - condition associated with persistence symptoms COVID-19 or reappearance 3 months illness. Most common features are: immune dysregulation, persistence, continued systemic inflammation, autoimmune dysorders, tromboses and endothelial damage,...
Na segodnyashnij den' aktualen analiz riska razvitiya serdechno-sosudistyh oslozhnenij u pacientov s gipertonicheskoj bolezn'yu (GB) posle perenesennoj novoj koronavirusnoj infekcii (COVID-19). Pokazana znachimost' lejkemiya-ingibiruyushchego faktora (LIF) i ego rastvorimogo receptora (sLIFr) v progressirovanii GB aktual'nost' cirkadiannyh podhodov ocenke vklada provospalitel'nyh citokinov patogenez ostrogo narusheniya mozgovogo krovoobrashcheniya (ONMK). Cel'yu issledovaniya bylo...
Today, the analysis of risk developing cardiovascular complications in patients with essential hypertension (EH) following recovery from novel coronavirus infection (COVID-19) is relevant. The value leukemia inhibitory factor (LIF) and its soluble receptor (sLIFr) EH progression has been shown, along relevance circadian approaches to assessment contribution pro-inflammatory cytokines pathogenesis acute cerebrovascular accidents (CVA). study aimed compare alterations LIF sLIFr levels during...
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Cytokines represent a unique family of endogenous polypeptide mediators intercellular interaction. From an immunopharmacological point view cytokines can be marked out as new, separate immunoregulatory molecule system and have some common biochemical properties pleiotropic type biological activity. In the cytokine regulatory both reduction elevation levels cause pathology. Several systems exist to control prevent tissue When synthesized simultaneously, form chain. Deletion any unit this...
Allergy is characterized by inadequate hyperimmune response to one or several antigens with the properties of allergens. A specific pattern abnormal synthesis some cytokines (principal molecular mediators initiation, development, and regulation allergic inflammation) has an important pathogenic role in allergy. In recent years, it generally accepted that disorders are accounted for impaired immune resulting from increased imbalanced activation allergen-specific T helper 2 cell clones....
Diagnosis of specific T cell immunity to the antigenic determinants SARS-CoV-2 in patients seems be an increasingly important task due accumulation data about role immune response course coronavirus infection and clearance case secondary infection. Previously, we designed recombinant CorD_PS antigen for evaluation antiviral immunity, containing conservative immunogenic sequences structural proteins coronavirus. E. coli producing strain with stable expression was obtained. Aim present work is...
Natural peptides with antimicrobial activity are extremely diverse, and peptide synthesis technologies make it possible to significantly improve their properties for specific tasks. Here, we investigate the biological of natural indolicidin indolicidin‐derived novel synthetic In‐58. In‐58 was generated by replacing all tryptophan residues on phenylalanine in D‐configuration; α‐amino group main chain also modified unsaturated fatty acid. Compared indolicidin, is more bactericidal, resistant...
T-cell immune response is extremely important in protecting human body from diverse viral infections. It known that it can ensure clearance and complete recovery patients with humoral immunodeficiency. COVID-19 were found to have primarily directed against SARS-CoV-2 structural S, M, N, E proteins, nucleocapsid protein being most conserved. To assess immunity coronavirus infection evaluate an effectiveness of vaccine candidates, necessary develop optimal diagnostic antigen arising antigenic...
This publication reflects modern ideas about the main aspects of etiology, pathogenesis and latest achievements clinical practice in field most common primary secondary immunodeficiency. The features laboratory diagnostics congenital immunodeficiency, risk factors early guidelines that allow patient to suspect an immunosuppressive state are considered. Special attention is paid problem their prevalence polyetiology. When covering immunopathogenesis, infection caused by human immunodeficiency...
The activation of various types epithelial, endothelial, and immunocompetent cells, along with hyperproduction cytokines other proinflammatory mediators the complement system, plays a crucial in pathogenesis coronavirus disease 2019 (COVID-19). These conditions leads to severe inflammation acute respiratory distress syndrome. Hyperinflammatory reactions lungs tissues result significant tissue damage organ dysfunction. A specific feature syndrome 2 infection is combination cell death...
Rotavirus infection is among leading causes of severe diarrhea which often leads to dehydration, especially, in children under 5 years old. In Russia, the incidence rotavirus constantly increased, due higher rates actual cases and improved diagnostics disease. Immunity unstable, thus causing repeated infections intra vitam. Anti-infectious resistance reconvalescents explained by induction specific IgM, IgG, and, notably, IgA antibodies. Due absence market drugs with direct action against...
Cytokines - family of polypeptide molecules, that are produced by tissue cells and regulate embryogenesis, some normal physiological functions, defense reactions to pathogens, several pathological processes including immunopathology, carcinogenesis, heart vascular pathology, etc. Different experiments led conclusion in case hyperproduction cytokines instead factors can become the mediators pathology. During infections elevated cytokine synthesis followed with inflammation depends on pathogen...
Latent rhinosinusitis proceeds without facial pain symptoms. Immune deficiency plays a leading role in pathogenesis of the disease latency. Substance P seems to be universal mediator painful irritation and inflammation. The objective our study was determine effectiveness therapies patients with latent rhinosinusitis, terms substance levels. We treated 148 being free local pains. All underwent clinical laboratory examination, including immune profile assessment, measurements serum cytokines...
We have examined 92 children aged between 6 and 15, suffering from chronic tonsillitis (CT). Tumor necrosis factor (TNF-α) interleukin 1β (IL-1β IL-6) contents been defined in saliva. The control set comprised 17 healthy children. Cytokine content was with the enzyme multiplied immunoassay sets (Vektor Best Ltd., Russia) by enzyme-linked immunosorbent assay. statistic analysis data processing were carried out programs (version 3.2, R Foundation for Statistical Computing, Vienna, Austria).The...
The purpose of this research is to study the characteristics change in circadian rhythm macrophage colony-stimulating factor (M-CSF) content peripheral blood serum patients with stage II essential hypertension (EH) based on 5 time points (8:00, 14:00, 20:00, 2:00, and 8:00) analyze its connection frequency cardiovascular events.Identified levels M-CSF 60 EH, before after 1 year antihypertensive therapy using enzyme-linked immunoassays (at 8:00, 8:00).The demonstrated that EH a medical case...
Microvesicles (MVs) are plasma extracellular vesicles ranging from 100 (150) to 1000 nm in diameter. These generally produced by different cells through their vital activity and a source of various protein non-protein molecules. It is assumed that MVs can mediate intercellular communication modulate cell functions. The interaction between natural killer (NK cells) endothelial underlies multiple pathological conditions. ability derived NK influence the functional state inflammatory conditions...