A5021977160- Neurological Disorders and Treatments
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal pain and rehabilitation
- Neurological Disease Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Spine and Intervertebral Disc Pathology
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Myofascial pain diagnosis and treatment
- Medicinal plant effects and applications
- Medical and Biological Sciences
- Long-Term Effects of COVID-19
- Pain Management and Placebo Effect
- Healthcare Systems and Public Health
- Alcoholism and Thiamine Deficiency
- Genetic Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Natural Products and Biological Research
- Human Health and Disease
- Migraine and Headache Studies
- Medicinal Plants and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
International Institute for Restorative Practices
2020-2025
International University
2020-2025
International University in Moscow
2021
Sechenov University
2006-2020
Ministry of Health of the Russian Federation
2020
Nonsteroidal anti-inflammatory drugs (NSAIDs) are usually prescribed either locally (topical forms) at the first stage, or orally second if effect of local pain relief when using NSAIDs has not been achieved. The combined use different forms with same NSAID molecule will enhance and prolong analgesic effect, reduce dosage oral drug, thereby risks adverse events (AE). Nimesulide is a representative sulfonanilide class among NSAIDs, refers to that inhibit mainly enzyme cyclooxygenan-2 (COX-2),...
To study the features of asthenic syndrome and possibilities its therapy in patients post-covid period.The included 129 with an average age 49.8±8.9 years who had undergone COVID-19 using a continuous sample method. Patients for were selected at clinical bases outpatient clinics Samara (Russia) July-August 2020. All signed informed consent form prior to enrollment. randomized into two groups: main group (n=64), ethylmethylhydroxypyridine succinate (Neurox) was prescribed 1 tablet (125 mg) 3...
Standardized extracts of undenatured type II collagen (UC-II) are used as alternative approaches to the treatment osteoarthritis (OA). The effect UC-II is associated with modulation mechanisms innate and acquired immunity, a decrease in activity proinflammatory cytokines prostaglandins. Epitopes native structure contribute autoimmune reactions that stimulate cartilage degradation. Interacting discoidin receptors, accelerates reconstruction connective tissue inhibits pro-inflammatory effects...
Asthenia, asthenic syndrome, condition, reaction, disorders are terms that describe the state of «impotence». Fatigue occurs against background habitual physical or intellectual stress for a person, and persists after rest, is asthenia. For people older age group, term senile asthenia syndrome used. Asthenia manifests itself with increased fatigue exhaustion, mood instability, irritability, sleep disorders. Asthenic conditions manifest themselves along decrease in activity, cognitive mental...
In recent decades, there has been an increase in the prevalence and medical social burden of osteoarthritis (OA) nonspecific back pain all countries world. The First Multidisciplinary Bilateral Russia-Uzbekistan Expert Council presented innovations prognosing, personalized prevention adjuvant therapy degenerative-dystrophic diseases joints spine, evidence base for effectiveness safety use drugs that modify course OA (Disease-modifying drugs, DMOADs): chondroitin sulfate, glucosamine...
The dominant collagen of the cartilaginous matrix in adults is type II collagen. amount intercellular cartilage significantly reduced against background musculoskeletal system diseases. basis articular hyaline tissue consisting chondrocytes with tissue-specific antigens that induce production antibodies patients osteoarthritis (OA). Today, new approaches are being considered treatment OA use udenatured (UC-II). Such molecular mechanisms action UC-II as formation a systemic response through...
Objective: the development and verification of a scale for identifying patients at high risk osteoarthritis (OA). Material methods. The results analysis sample aged 35–90 years from database Institute Trace Elements ( n =3440), which included information on clinical anamnestic, diagnostic parameters pharmacotherapy patients, including with OA =107), are presented. To analyze about modern methods data proposed within topological theory pattern recognition were used. Results. Based sample,...
Understanding the major pathological pathways and key molecules involved in pathogenesis of inflammatory processes joints, particularly osteoarthritis (OA), is crucial for drug pharmaconutraceuticals development. OA a degenerative joint disease that predominantly affects articular cartilage. Destruction hyaline cartilage restructuring subchondral bone are accompanied by synovial inflammation joint, including facet spine, manifested pain low back (LBP), limitation functional activity. The...
Diagnostic criteria and approaches to the therapy of anxiety syndromes were considered. The basic method treatment is psycho-pharmacologic selected depending on type prevailing disorder degree its severity. drug selection depends severity duration disease.
Great value in the treatment of ischemic stroke (IS) is given for neuroprotection. When neuroprotection aims to increase period 'therapeutic window' and stop cascade pathological reactions. The defined as continuous adaptation neuron new functional conditions, key reducing damage brain tissue caused by ischemia, it acts at level molecular leading dysfunction death neurons. Special attention paid study properties low weight neuropeptides that penetrate through hematoencephalitic barrier exert...
Osteoarthritis (OA) is a painful and disabling disease that affects millions of people around the world. OA most common form arthritis characterized by joint pain stiffness, leading to decrease in functional activity loss quality life. Approaches therapy are constantly being revised, as new molecules appear, data on drugs/molecules already use, including adverse events, randomized controlled trials results, methods adjunctive become available. prevention, drugs with chondroprotective...
The review examines pharmacological agents that can have potential disease-modifying osteoarthritis drugs (DMOADs) status. DMOADs prevent the progression and further structural joint damage (structure-modifying effect), leading to a decrease in symptoms severity (symptom-modifying such as pain, improvement of function. Approaches selection are discussed: (1) preferred target (bone, cartilage, synovia); (2) action drug mechanism/anti-cytokine therapy (matrix metalloproteinase inhibitors,...
Insufficiency of a choline derivative (acetylcholine) can lead to the development cognitive impairment (CI). One most well-known and well-studied medical drugs (MD) containing having neuroprotective properties is citicoline (Recognan). A number studies have demonstrated effectiveness Recognan in relation mild CI, chronic cerebrovascular diseases (CVD), acute vascular disorders (including post-traumatic genesis). improves memory other functions healthy young people against background asthenia...
A case-report of burning mouth syndrome is presented. 27-year-old man complained pain in the tongue and oral mucosa, taste disorder, sensory impairment. All symptoms appeared after suffering a cold had wave-like course during self-medication with antibiotics. The has continued for 8 months. Diagnoses atypical facial pain, glossodynia or secondary (craniomandibular dysfunction) were made. effect treatment hospital (carbamazepine, amitriptyline, haloperidol, phenozepam) was not achieved....
Biological ageing is a process that changes living systems over time, causing impairments in their structure and function. Studying the individual biomarkers of regarded as most plausible current theory age-related inflammatory processes (inflammageing). According to this theory, slightly pronounced chronic aseptic inflammation develops during ageing, which basis for pathogenesis syndromes diseases. A key role implementing different cellular interactions regulating type an response assigned...
To study the effect of cavinton comforte (CC) on severity cognitive impairment and motor awkwardness in patients with chronic brain ischemia (HIGM).There were 30 (8 men, 22 women) aged 50-65 years (61.6±4.9 average) AHU impairment. We used tests MINI-Cog, Munsterberg, TMT), ADL). QC appointed 10 mg 3 times a day for months.Against background therapy, improvement constructive praxis short-term memory, an increase speed visual search visual-motor function, level selectivity attention,...
The prevalence of osteoarthritis (OA) increases in proportion to age, so the population people over 65 years age. pathogenesis OA is based on inflammation cartilage tissue joint, which leads damage cartilage, activation signaling pathways and increased levels cytokines. Aim.To study literature data bone remodeling with development resorptive processes discuss possible algorithms recommendations for management patients background chondroprotective therapy. Materials methods.A comprehensive...
Vibration disease (VD) (pneumatic hammer disease) is a leader among occupational diseases. The prolonged use of vibrating tools high health risk. clinical picture VD caused by local vibration includes sensorineural and upper extremity locomotor impairments that are polymorphic, polysyndromic, not always specific. International List Occupational Diseases (2010) defines using the terms «vibration-induced white finger» (VWF) «hand-arm syndrome» (HAVS). VWF as manifestation secondary Raynaud’s...
In preclinical and clinical studies, choline alfoscerate (CA) has proven to be highly effective in the correction of cognitive impairment (CI). The effect CA is seen improvement mental activity, concentration, ability remember recall information, behavioural responses, elimination emotional instability apathy. Experimental studies have shown effectiveness preventing atrophic changes cerebral cortex. Based on several conducted use treatment CI, it can concluded that oral administration at a...