A5014097665- Neurological Disorders and Treatments
- Healthcare Systems and Public Health
- Atrial Fibrillation Management and Outcomes
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Cardiac Health and Mental Health
- Pain Mechanisms and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- COVID-19 Clinical Research Studies
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Eicosanoids and Hypertension Pharmacology
- Cancer Treatment and Pharmacology
- Biomarkers in Disease Mechanisms
- Cardiac Imaging and Diagnostics
- Medical and Biological Sciences
- Proteoglycans and glycosaminoglycans research
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
Samara State Medical University
2015-2024
Ministry of Health of the Russian Federation
2017-2021
Samara City N.I. Pirogov Clinical Hospital №1
2017
St. Petersburg State Medical Academy "City Polyclinic №44"
2015
.
By the middle of 2021, official global number coronavirus disease 2019 (COVID-19) patients was close to 230 million, but accounting for asymptomatic much higher. Consequences and rehabilitation after COVID-19 are particular interest raise many controversial unresolved issues. On May 18, Eurasian Association Therapists organized an international panel experts analyze challenges associated with post-COVID-19 period. This aimed develop approaches identify gaps in discussed interdisciplinary...
To evaluate the antiresorptive-cytokine effects of chondroitin sulfate on non-specific lower back pain in patients with knee osteoarthritis (OA).Using envelope method, 231 were randomized into two groups: group 1 (n=116, main) received nonsteroidal anti-inflammatory drugs (NSAIDs) and chondrogard, 2 (n=115, comparison) only NSAIDs. The 2-month study included 3 visits (V): V1 - at beginning study, V2 after 10 days, V3 60 days assessment blood parameters: transforming growth factor β1 (TFR...
To evaluate the possibility of using symptomatic slow acting drugs for osteoarthritis (SYSADOA) in patients with nonspecific lower back pain and high cardiovascular risk.The study registered as observational program 'Possibilities SYSADOA-therapy risk' was organized outpatient clinics sequential inclusion (n=315) pain. All randomized into 5 main groups by method envelopes were treated different SYSADOA. The control group (group 6) included 63 without syndrome. duration follow-up 9 months....
To compare the efficacy and tolerability of different combinations domestic generics meloxicam (amelotex), tolperisone (calmirex) B vitamins (compligam B) in treatment acute low-back pain.Ninety patients with pain (ICD-10 M54.5) were studied. Indications prescribing drugs was carried out under international generic name. Pain assessed using a visual analog scale mm (VAS). relieve pain, all received non-steroidal anti-inflammatory drug favorable safety profile (amelotex). With aim...
<h3></h3> Пандемия новой коронавирусной инфекции была объявлена в январе 2020 г. Течение острого периода заболевания, способы лечения и ведения пациентов на сегодняшний день изучены достаточном объеме. В настоящее время крайне актуален вопрос изменений организме восстановительном периоде с исследованием факторов риска декомпенсации их соматического статуса. <h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Изучение течения артериальной гипертензии (АГ) у после перенесенной инфекции, связи АГ со степенью тяжести...
Biological ageing is a process that changes living systems over time, causing impairments in their structure and function. Studying the individual biomarkers of regarded as most plausible current theory age-related inflammatory processes (inflammageing). According to this theory, slightly pronounced chronic aseptic inflammation develops during ageing, which basis for pathogenesis syndromes diseases. A key role implementing different cellular interactions regulating type an response assigned...
Objective: to investigate the impact of anticoagulant therapy on indicators arterial stiffness and endothelial dysfunction (ED) in patients with atrial fibrillation (AF) after cardioembolic stroke (CES). Patients methods. The investigation enrolled 93 AF CES. were divided into two groups: a study group which all (n=48) received anticoagulants comparison (n=45) did not take anticoagulants, although latter had been prescribed. follow-up duration was 180.5±5.5 days. During this time visited...
Aim. To study the adherence to anticoagulation therapy of AF patients after CES, in real clinical practice. Material and methods. From 01.10.2013 31.03.2015 data was analyzed, 1291 those 661 fulfilled inclusion/exclusion criteria (36,9% males 63,1% females, mean age 68 y.o.). During 12-month period follow-up, 2 phone calls performed, 180±5 days (V1) 360±5 (V2) from stroke onset. Results. In 2014 only 6,9% participants were taking anticoagulants, 2015 — 17,5%. Only a half (n=330) knew they...
The prevalence of osteoarthritis (OA) increases in proportion to age, so the population people over 65 years age. pathogenesis OA is based on inflammation cartilage tissue joint, which leads damage cartilage, activation signaling pathways and increased levels cytokines. Aim.To study literature data bone remodeling with development resorptive processes discuss possible algorithms recommendations for management patients background chondroprotective therapy. Materials methods.A comprehensive...
To study the impact of therapy with nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, meloxicam, etoricoxib, and nimesulide, on systolic diastolic blood pressure (BP) changes in a short period (3 days), well risk acute transient ischemic attack, hemorrhagic stroke, cardiovascular events within 6 months after NSAID use.The follow-up included 66 patients (34 women 32 men) who took NSAIDs for emergent low back pain.The findings may suggest that etoricoxib-based is highly...
To evaluate the safety of etoricoxib in patients with acute nonspecific back pain associated high risk cardiovascular events (CVE) clinical practice.The open prospective follow-up by a simple randomization method included 80 patients, including 49 women and 31 men (mean 60.8±4.7 years). The were randomized into 4 groups 20 persons each: 1) 90 mg/day; 2) nimesulide 100 3) diclofenac 4) meloxicam 15 mg/day. investigation lasted 90±4.5 days. interim evaluation criteria (study points) changes...
Background. In oncohematology, microcirculatory disorders in patients with coexistent myeloproliferative diseases and arterial hypertension (HTN) are poorly understood. The aim of study was to investigate changes microcirculation polycythemia vera (PV) HTN by laser Doppler flowmetry. Design methods. We examined 76 PV, among them 49 had PV HTN. Microcirculatory were assessed survey carried out a standard procedure, which included three methods: flowmetry, optical tissue oximetry pulse...
Chronic pain (CP) is still one of the urgent problems modern medicine. The paper provides a review main pharmacotherapeutic approaches from standpoint European Society for Clinical and Economic Aspects Osteoporosis Osteoarthritis (ESCEO) guidelines. When preparing this material, authors have analyzed publications available in resources: PubMed, EMBASE, Cochrane, еLIBRARY. presents pathogenetic mechanisms syndrome development osteoarthritis (OA), including synovial inflammation associated...
Objective. The subanalysis of the study “PANDA” (the renal function in patients with acute nonspecific pain lower back during therapy nonsteroidal anti-inflammatory drugs (NSAID)) is renal-associated escape effect antihypertensive arterial hypertension (HTN) receiving NSAID. Design and methods. We included 407 one following NSAIDs for 14 days: meloxicam (15 mg/day), etoricoxib (60 nimesulide (200 mg/day) or celecoxib mg/day). Five visits were performed. During blood pressure (BP), glomerular...
Aim of the study – reveal clinical efficacy naftidrofuryl in aspect correcting structural and functional changes microcirculation (MC) relation to influence endothelial dysfunction (ED) parameters comorbid patients suffered stroke event. Materials methods. The included 95 ischemic type carotid bassin. An average age was 69.0 ± 5.3 years, duration 73.5 8.4 days. Patients were randomized 2 groups by using blind method envelopes. mentioned matched on main demographic characteristics. from 1st...
Investigation of the clinical and economic advisability using self-adhesive wound bandages plaster type (on example Cosmopor E steril) compared to gauze in conditions medical organization.
Coronary heart disease is the leading cause of death for both women and men. Older women, when coronary first appears, have more comorbidities usually complain atypical symptoms. Mortality hospitalization rates caused by acute myocardial infarction are higher women. It should be noted that adherence to secondary prevention lower. Female predominance has been in idiopathic pulmonary arterial hypertension (IPAH), hereditary hypertension, collagenosisassociated hypertension. However, according...
Objective: to evaluate the clinical efficacy and tolerability of Russian drug tolperisone (calmyrex) versus tizanidine baclofen in therapy acute nonspecific musculoskeletal pain (NSMSP) elderly. Patients methods. Examinations were made 135 elderly (60–75-year-old) patients with NSMSP. To relieve syndrome, all prescribed nimesulide suspension 100 mg twice a day after meals. The randomized using an envelope method three groups, each which took muscle relaxant as tablets for 15 days: Group 1...
Aim. To assess eft ventricular (LV) contractility dysfunction in patients with chronic lymphocytic leukemia (CLL) receiving chemotherapy fludarabine, cyclophosphamide, and rituximab (FCR), to determine the enalapril.effectiveness for their treatment. Material methods. The study included 49 newly diagnosed Binet stage B CLL combination class I-II stable angina, 1-2 hypertension LV ejection fraction (EF) >50%. All subjects did not take angiotensin converting enzyme inhibitors (ACE...
Aim. To investigate whether of anxiety-related blood pressure (BP) variability can be corrected in patients with atrial fibrillation (AF) who have experienced cardioembolic stroke (CES). Subjects and methods. The investigation enrolled 125 (mean age, 68.5±5.7 years) AF, had CES. were randomized into 2 groups by the envelope technique: 1) 63 received antihypertensive drugs an anxiolytic (adaptol) (a study group); 2) 62 only comparison group). Effectiveness was evaluated 6 weeks later from...