A5025174599- Biomedical Text Mining and Ontologies
- Lipoproteins and Cardiovascular Health
- Glycosylation and Glycoproteins Research
- Neurological Disorders and Treatments
- Biochemical Acid Research Studies
- Cardiovascular Disease and Adiposity
- Genomics and Phylogenetic Studies
- Neurological Disease Mechanisms and Treatments
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Lipids, and Metabolism
- biodegradable polymer synthesis and properties
- Cardiovascular Health and Disease Prevention
- Semantic Web and Ontologies
- Alcoholism and Thiamine Deficiency
- Genetic and phenotypic traits in livestock
- Carbohydrate Chemistry and Synthesis
- Antioxidant Activity and Oxidative Stress
- Glycogen Storage Diseases and Myoclonus
- Endoplasmic Reticulum Stress and Disease
- Plant Disease Resistance and Genetics
- Proteoglycans and glycosaminoglycans research
- Enzyme Production and Characterization
- Hip disorders and treatments
Pirogov Russian National Research Medical University
2016-2023
Ministry of Health of the Russian Federation
2015-2023
National Agriculture and Food Research Organization
2022-2023
National Institute of Advanced Industrial Science and Technology
2006-2018
Institute for Atherosclerosis Research
2016-2017
University of Tsukuba
2008
Institute of Experimental Cardiology
1999-2001
Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover surfaces many cells, serving 'face' whereby other biomolecules viruses interact. The structure glycans, however, differs greatly from proteins in that they branched, opposed linear sequences amino acids or nucleotides. Therefore, storage glycan information databases, let alone their curation, has been a difficult problem. This caused duplicated efforts when integration is attempted between...
Transposition event detection of transposable element (TE) in the genome using short reads from next-generation sequence (NGS) was difficult, because nucleotide TE itself is repetitive, making it difficult to identify locations its insertions by alignment programs for NGS. We have developed a program with new algorithm detect transpositions NGS data. In process tool development, we used data derivative lines (ttm2 and ttm5) japonica rice cv. Nipponbare, regenerated through cell culture. The...
In recent decades, there has been an increase in the prevalence and medical social burden of osteoarthritis (OA) nonspecific back pain all countries world. The First Multidisciplinary Bilateral Russia-Uzbekistan Expert Council presented innovations prognosing, personalized prevention adjuvant therapy degenerative-dystrophic diseases joints spine, evidence base for effectiveness safety use drugs that modify course OA (Disease-modifying drugs, DMOADs): chondroitin sulfate, glucosamine...
Optimal conditions for obtaining phosphatidylholine (PC) liposomes with lipoic acid (LA) are chosen that lead to the formation of nanoparticles a size 175¸284 nm efficiency (extent) inclusion LA in equal 85% and characterized by slow release substance from nanoparticles. The effect “empty” liposomal form on platelet aggregation induced arachidonic (AA) is established. It found LА inhibit aggregation, caused AА, 80%. In addition, it shown slightly (to 30%) suppress AА. amount TBA-sensitive...
On June 25-26, 2021, a round table was held in Kazan with the participation of leading neurologists Russia, where issues treatment patients cognitive impairment due to cerebrovascular diseases were discussed. Cognitive disorders vascular genesis (VCD) are widespread population, common cause decrease quality life and restriction daily activity. The VCD is both acute chronic diseases. An effective way prevent control cardiovascular risk factors, ensure sufficient level physical activity...
To perform a pharmacoeconomic analysis of the most frequently prescribed neuroprotective medicines for treating patients with mild ischemic stroke in acute and early rehabilitation periods Russian Federation.Three medical technologies were compared: ethylmethylhydroxypyridine succinate (mexidol), inosine + nicotinamide riboflavin succinic acid (cytoflavin) deproteinized hemoderivate blood calves (actovegin). Cost minimization analysis, budget impact sensitivity performed based on indirect...
Abstract Background Population structure and cryptic relatedness between individuals (samples) are two major factors affecting false positives in genome-wide association studies (GWAS). In addition, population stratification genetic genomic selection animal plant breeding can affect prediction accuracy. The methods commonly used for solving these problems principal component analysis (to adjust stratification) marker-based kinship estimates correct the confounding effects of relatedness)....
Inherited mutations in glyco-related genes can affect the biosynthesis and degradation of glycans result severe genetic diseases disorders. The Glyco-Disease Genes Database (GDGDB), which provides information about these disorders as well their causative genes, has been developed by Research Center for Medical Glycoscience (RCMG) released April 2010. GDGDB currently on 80 caused single-gene genes. Many biomedical resources provide involved pathogenesis, but focused known to be related glycan...
Cerebrovascular diseases (CVD) are the main cause of death and permanent disability. The urgency problem chronic CVD is associated with an increase absolute number elderly senile age in population, a trend towards slowly increasing, sluggish pathological processes. It obvious that any somatic disease such patients comorbid to cerebrovascular suggests unified mechanism pathogenesis for both concomitant diseases. article notes microangiopathy most common CVD. etiopathogenetic factor affecting...
Wheat (Triticum aestivum L.) and barley (Hordeum vulgare are widely cultivated temperate crops. In breeding programs with these crops in Japan, effective genomic-assisted selection was performed by selecting core marker sets from thousands of genome-wide amplicon sequencing markers. The consist 768 960 markers for wheat, respectively. These distributed evenly across the genomes effectively detect polymorphisms chromosomes. set utility assessed using 1,032 1,798 wheat accessions country....
Pain is a complex of sensory and emotional reactions including nociceptive, nociplastic neuropathic components. In addition, back pain associated with musculoskeletal syndrome holds specific (and even leading) place in clinical practice. These patients need comprehensive individualized therapy. Due to diverse pathophysiological mechanisms (MSP), new therapeutic approaches several targets at once considering synergy between different analgesics multiple action focused on nociception control,...
The Integrated Life Science Database Project of Japan funded a group glycoscientists to carry out project integrate glycoscience databases using Semantic Web technologies. As continuation the previous period, Consortium for Glycobiology and Glycotechnology (JCGGDB) developed several glycoscience-related databases. GlycoProtDB database is among those being integrated, providing an important resource understand protein glycosylation. Another integrated GlycoEpitope, comprehensive carbohydrate...
我々は，XML/RDF (Resource Description Framework 技術をアレルギーに関する知識領域への適用を試みた．その領域には複雑なデータ構造と、データ要素・リソース間の意味関係が存在する．本論文の目的は次の３要素で構成される．(i)アレルギー疾患の要因に関する知識領域を最適に表現するために，概念の群およびそれら概念間の関係を記述するオントロジーを設計・開発すること；(ii)アレルギー疾患に関係する情報資源の主題索引に本オントロジーを適用すること；(iii)構築したオントロジーと索引を用いて情報資源からデータを検索することの３つである．メタデータの構造化，表現そして蓄積はセマンティクウェブ技術であるRDF とSimple Knowledge Organisation System (SKOS)を用いて実行した．一方，Web リソース自体の構造はXML フォーマットを用いて記述した．セマンティクWeb 技術とXML によって表現された情報を検索するために，我々はWeb アプリケーションのプロトタイプを開発した．また，RDF と他のセマンティクWeb...
Atherosclerosis and it’s clinical implications (myocardial infarction, stroke, intermittent lameness) is a serious medico-social problem in Russia. Statins (or HMG-CoA reductase inhibitors) are the first-choice agents to prevent cardiovascular disease events. The paper presents results of early regression studies modern using MRI imaging concerning or stabilization atherosclerosis rationale baseline characteristics russian study “FREGAT”.