A5032323672- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Neuroblastoma Research and Treatments
- Acute Myeloid Leukemia Research
- Chemotherapy-related skin toxicity
- Polyomavirus and related diseases
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- DNA Repair Mechanisms
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Hemoglobinopathies and Related Disorders
- Cancer and Skin Lesions
- PI3K/AKT/mTOR signaling in cancer
- Lymphoma Diagnosis and Treatment
- Mycobacterium research and diagnosis
- T-cell and B-cell Immunology
- Analytical Chemistry and Chromatography
- Bacterial Identification and Susceptibility Testing
- Neutropenia and Cancer Infections
- Melanoma and MAPK Pathways
- Mesenchymal stem cell research
- Ocular Oncology and Treatments
Ministry of Health of the Russian Federation
2020-2024
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2020-2021
Elusys Therapeutics (United States)
2007
Hematopoietic stem cell transplantation (HSCT) is a treatment method for number of severe malignant and non-tumor diseases. Autologous (auto) allogeneic (allo) HSCT improves outcomes in patients with solid hematological malignancies. The toxicity conditioning regimens before often limiting factor successful transplant outcomes. most common manifestations visceral tissue are epithelial (dermatological mucosal) toxicity, hepatotoxicity, neurotoxicity. Reducing the incidence toxic complications...
High dose chemotherapy (HDCT) with autologous hematopoietic stem cell transplantation (auto-HSCT) is used currently as a consolidating stage in cancer treatment protocols for children from different age groups various malignant neoplasms. Auto-HSCT can improve both progression-free survival and overall of such patients. At the same time optimization collection cells (HSCs) seems to be an important factor successful implementation auto-HSCT. The purpose this research was evaluate safety...
Treatment of non-Hodgkin lymphomas (NHL) in children using risk-based chemotherapy protocols is currently effective 80–95% cases, even advanced stages the disease. However, relapsed/refractory forms NHL (which are less common) have an extremely unfavorable course with low survival rates. The addition autologous and allogeneic hematopoietic stem cell transplantation (HSCT) to a comprehensive treatment program for can improve results due antitumor effect drugs conditioning regimen...
High-dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation (auto-HSCT) is a therapeutic option that allows potentiating the antitumor effect in patients with malignant neoplasms (MNs) belonging to high-risk group. However, despite effectiveness of this method, risks developing infectious and toxic complications early late post-transplantation period are higher than associated treatment according standard protocols can significantly worsen results...
Background . Blueberry muffin baby syndrome in newborns is characterized by diffuse nodular skin lesions and it difficult for diagnosis due to diverse etiology. Etiological factors include congenital infections, intrauterine hemolytic disease, multifocal vascular abnormalities, neoplastic conditions. Congenital neonatal leukemia rare disease usually revealed during the first month of life. Clinical case description This clinical presents a patient with acute myeloid severe manifestations....
Currently, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment option for relapsed / refractory (R R) acute leukemia (AL) and high-risk AL. In this article, we present our own experience of allo-HSCT in children with R The study was approved by the Independent Ethics Committee Scientific Council N. Blokhin National Medical Research Center Oncology. Fifty-one patients AL were included study: 32 had lymphoblastic (ALL), 17 myeloid (AML) 2 biphenotypic (BL)....
Veno-occlusive liver disease (VOD), now more often referred to as “sinusoidal obstruction syndrome” (SOS), is a symptom complex that develops in the early stages after hematopoietic stem cell transplantation and some chemotherapy regimens due toxicity of number drugs used accompanied by following symptoms: hyperbilirubinemia, fluid retention, weight gain, painful hepatomegaly. According various sources, incidence SOS/VOD patients with oncohematological profile ranges from 3 15 %. At present,...
Retinoblastoma (RB) is the most common malignant eye tumor in children accounting for 10-15% of all cancer cases infants.In spite generally good standard treatment results there still a subgroup high-risk patients with by unfavorable prognosis, which warrants search additional strategies.These may benefit from intensification form high-dose consolidation subsequent autologous hemopoietic stem cell therapy (auto-HSCT).We here describe case series illustrating N. Blokhin Cancer Center...
Introduction . So far there has been no clear protocol on the treatment of bacterial infections in hematopoietic cancer patients undergoing polychemotherapy (PCT) and stem cell transplantation (HSCT). Guidelines available from antibiotic therapy panels such as EMBT, NCCN, ECIL, Sepsis-3 often fail to cover entire spectrum clinical risk factors severe complications caused specifically by multiresistant Klebsiella pneumoniae. The aim study — is showcase experience demonstration Research...
Fanconi anemia (AF) is a hereditary genetic disease characterized by developmental abnormalities, progressive bone marrow failure, hypersensitivity to alkylating agents, and tendency hematological solid tumors throughout life. The only curative option in the treatment of failure patients with AF allogeneic hematopoietic stem cell transplantation (allo-HSCT). There are no detailed descriptions allo-HSCT Russian-language literature. On example clinical case at onset myelodysplastic syndrome,...
There is no doubt that allogeneic hematopoietic stem cell transplantation (allo-HSCT) one of the most effective treatments for many serious diseases. However, despite significant progress, allo-HSCT still associated with a high rate complications and mortality in posttransplant period due to toxicity conditioning regimens, infectious immune conditions. Acute such as endothelial injury, acute chronic graft-versus-host disease (GVHD) remain main causes after allo-HSCT. In our clinical case, we...
Pigmented epithelioid melanocytoma (PEM) is an uncommon, recently described melanocytic lesion. There a high rate of regional metastases, but limited evidence distant indolent clinical course and favorable outcome. The article presents case PEM with aggressive behavior metastases in patient Fanconi Anemia after hematopoietic stem cell transplantation. Parents gave their consent to use information about the child, including fotos, article.
One of the complications arising at stage hematopoietic stem cell transplantation (HSCT) is skin lesions. This complication quite common and represents an important diagnostic therapeutic problem. The main cause lesions in HSCT drug toxicity, but also infectious Each can manifest itself varying degrees, as well be combined with others, having a significant negative effect on patient’s condition, severe cases posing threat to life. paper presents clinical case patient treosulfan toxicoderma...