A5016972753- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Infant Development and Preterm Care
- Cerebrospinal fluid and hydrocephalus
- Neuroscience of respiration and sleep
- Cerebral Venous Sinus Thrombosis
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Advanced Neuroimaging Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Epilepsy research and treatment
- Acute Myeloid Leukemia Research
- Neurological and metabolic disorders
- Retinopathy of Prematurity Studies
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Non-Invasive Vital Sign Monitoring
- Pediatric Pain Management Techniques
- Complement system in diseases
- Infant Nutrition and Health
- Anesthesia and Neurotoxicity Research
Istituto Giannina Gaslini
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2022
University of Genoa
2021
Privolzhsky Research Medical University
2015
Perm State Medical Academy
2007
Objective: To assess diagnostic accuracy of cranial ultrasonography (CUS) in detecting low-grade (i.e. grade I and II) germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) very low birth weight (VLBW) infants.Methods: Among VLBW infants who were admitted to Gaslini Children's Hospital neonatal intensive care unit between January November 2012, patients underwent both serial CUS since magnetic resonance susceptibility-weighted imaging (SWI) at term-equivalent age included this...
To assess diagnostic accuracy of cranial ultrasound (CUS) performed through the anterior fontanelle (AF) and mastoid (MF) in detecting cerebellar haemorrhages (CBH) very low birthweight (VLBW) infants.Third-level neonatal intensive care unit (NICU).VLBW infants consecutively admitted at Gaslini Children's Hospital between February 2012 September 2013 underwent both CUS MR susceptibility-weighted imaging (SWI). was days 1, 2, 3 7 after birth, then weekly until term-equivalent age. All...
Early exposure to nociceptive events may cause brain structural alterations in preterm neonates, with long-lasting consequences on neurodevelopmental outcome. Little is known the extent which early pain affect connectivity. We aim evaluate functional connectivity changes neonate that underwent multiple invasive procedures during postnatal period, and correlate them outcome at 24 months.In this prospective case-control study, we collected information about painful period resting-state...
In recent decades, there has been a general increase in survival rates of preterm and low birth weight infants, but this overall decrease perinatal mortality not accompanied by long-term physical mental disability. order to reduce the sequelae prematurity establish preventive measures, it is important identify risk factors since main determinant specific vulnerability different types lesions gestational age. The regional tissue at given age probably determined local metabolic requirements...
Background and purpose: Perforator stroke (PS) is a subtype of perinatal arterial ischemic (PAIS), in which injuries occur the territory perforator branches main cerebral arteries. This study aims to explore incidence, timing, risk factors, clinical presentation PS both preterm full-term neonates. Material methods: We retrospectively analyzed data about all neonatal brain MRIs carried out our hospital from March 2012 2023. Criterium inclusion was radiologically confirmed diagnosis involving...
Background and purpose The anatomy of the deep venous system plays an important role in pathogenesis brain lesions preterm as shown by different histological studies. aims this study were to compare subependymal vein neonates with germinal matrix haemorrhage–intraventricular haemorrhage (GMH–IVH), evaluated susceptibility-weighted imaging (SWI) venography, a group age-matched controls normal MRI, explore relationship between anatomical features veins clinical risk factors for GMH–IVH....
Background: Children born very preterm (PT) after fetal growth restriction (FGR) exhibit cognitive impairment at early school age. The relationship between neurodevelopmental and attained regional brain volumes is unknown. Methods: We studied 23 children with FGR (PT-FGR), 24 matched AGA (PT-AGA), 27 term (T-AGA) by measuring magnetic resonance imaging Cognitive motor functions were assessed the Wechsler Intelligence Scales for ABC-Movement score. Results: mean (SD) full-scale IQ was 80 (17)...
During the last decades, severe brain lesions affecting very low birth weight (<1500 gr, VLBW) infants were gradually substituted by milder with debatable prognoses.The objective of this study is to define type, frequency and 3 years neurodevelopmental outcome prematurity-related in a modern cohort VLBW infants.VLBW admitted our NICU 5 period MRI at term-equivalent age included. scans reviewed identify grade white matter (WML), intraventricular hemorrhage (IVH), cerebellar (CBH). Linear...
<h3>BACKGROUND AND PURPOSE:</h3> The anatomy of the deep venous system is characterized by a great variability that might play an important role in pathogenesis brain lesions preterm brain. aim this study was to compare cerebral subependymal veins evaluated on SWI venography 3 groups neonates with normal MR imaging (very [gestational age <32 weeks], moderate-to-late ≥32 ≤37 and term >37 weeks]) evaluate influence birth development veins. <h3>MATERIALS METHODS:</h3> venographies 84 very...
Many neonatal intensive care units (NICUs) have adopted the practice of performing routine brain MRI in very low birth weight (VLBW) infants at term-equivalent age order to better evaluate prematurity-related acquired lesions. A number unexpected abnormalities potential clinical significance can be visualised on scans as well. The aim our study was describe these incidental findings (IFs) a VLBW population and assess their significance.We retrospectively reviewed series performed...
Germinal matrix-intraventricular hemorrhage (GMH-IVH) is a common form of intracranial occurring in preterm neonates that may affect normal brain development. Although the primary lesion easily identified on MRI by presence blood products, its exact extent not be recognizable with conventional sequences. Quantitative susceptibility mapping (QSM) quantify spatial distribution magnetic within biological tissues, including degradation products.To evaluate normal-appearing white (WM) and gray...
Extra-uterine growth restriction (EUGR) is a common complication and known risk factor for impaired development in very-low-birth-weight (VLBW) neonates. We report population of 288 patients with no or low-grade MRI lesions scanned at term equivalent age (TEA) born between 2012 2018. Griffiths Mental Development Scale II (GMDS II) 2 3 years, preterm complications weight were retrospectively analyzed. EUGR was defined z-score ˂ 10 percentile TEA, 6 12 months correct as decreased by 1-point...
Early extubation is considered to be beneficial for pre-term neonates. On the other hand, premature can cause lung derecruitment, compromised gas exchange, and need reintubation, which may associated with severe brain injury caused by sudden cerebral blood flow changes. We used near infrared spectroscopy (NIRS) investigate changes in oxygenation (rScO2) fractional tissue oxygen extraction (+) after infants. This a single-center retrospective study of NIRS data at time all consecutive...
Background: The pathogenesis of punctuate white matter lesions (PWMLs), a mild form damage observed in preterm infants, is still debate. Susceptibility-weighted imaging (SWI) allows to differentiate PWMLs based on the presence (SWI+) or absence (SWI–) hemosiderin, but little known about significance this distinction. This retrospective study aimed compare neuroradiological and clinical characteristics SWI+ SWI– PWMLs. Materials Methods: MR images all VLBW infants scanned consecutively at...
The objective of this study was to describe the clinical and neuroradiological characteristics a cohort preterm infants who had undergone external ventricular drain insertion as temporary measure treat posthemorrhagic dilatation. In addition, authors investigated factors predicting permanent shunt dependency.