A5014181818- Botulinum Toxin and Related Neurological Disorders
- Plant-based Medicinal Research
- Neurological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Human Health and Disease
- Pancreatitis Pathology and Treatment
- Poisoning and overdose treatments
- SARS-CoV-2 and COVID-19 Research
- Anesthesia and Neurotoxicity Research
- Retinal Development and Disorders
- Phagocytosis and Immune Regulation
- Biomarkers in Disease Mechanisms
- Urticaria and Related Conditions
- Diabetes and associated disorders
- Urinary Bladder and Prostate Research
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Adipose Tissue and Metabolism
- Dermatology and Skin Diseases
- Renal function and acid-base balance
- Biochemical effects in animals
- Hydrogen's biological and therapeutic effects
- Vitamin C and Antioxidants Research
- Birth, Development, and Health
- Circadian rhythm and melatonin
V.A. Negovsky Scientific Research Institute of General Reanimatology
2019-2025
Sechenov University
2019-2025
City Clinical Hospital
2024
Ministry of Health of the Russian Federation
2019-2023
CARE USA
2022
Resuscitation Council
2022
Anna Needs Neuroblastoma Answers
2020
Omsk State Medical University
2007-2019
The ongoing COVID-19 pandemic calls for more effective diagnostic tools. T cell response assessment serves as an independent indicator of prior exposure while also contributing to a comprehensive characterization SARS-CoV-2 immunity. In this study, we systematically assessed the immunogenicity 118 epitopes with immune cells collected from multiple cohorts vaccinated, convalescent, healthy unexposed, and SARS-CoV-2-exposed donors. We identified 75 immunogenic epitopes, 24 which were...
The article is devoted to the study of processes occurring in female body during extinction reproductive function, characterized by physical, endocrine, and psychological changes that negatively affect quality life. role pineal gland hormone melatonin development age-related reflected. prospects using a drug based on Pineamine polypeptides modern laser therapy methods treatment pathological conditions associated with hormonal imbalance due system or diseases accompanied premature ovarian...
Aim of the study . To determine effects xenon exposure at a dose 0.5 MAC different duration on content and enzyme-inactivating phosphorylation glycogen synthase kinase-3β (GSK3β) in perifocal zone ischemic cerebral infarction an experimental setting. Materials methods The Long method was used for modelling brain ischemia/reperfusion 39 rats weighing 300-350 g. Study group animals exposed to during 30, 60 120 minutes whereas control received oxygen-air mixture. Sham-operated served as...
The search for sensitive and specific markers enabling timely identification of patients with a life-threatening novel coronavirus infection (COVID-19) is important successful treatment. aim the study was to examine association molecular biomarkers air-blood barrier damage, surfactant proteins SP-A SP-D Club cell protein CC16, outcome COVID-19. Materials methods . A cohort 109 diagnosed COVID-19 retrospectively divided into two groups. Group 1 comprised survivor discharged from ICU (w=90). 2...
Aim. To investigate the cardioprotective effect of lithium chloride in vivo on a rat model myocardial infarction.Methods. Twelve male Sprague-Dawley rats were randomly divided into two groups six, with both modelling cardiac ischaemia and subsequent reperfusion. At start reperfusion, 30 mg/kg 4.2% solution was intravenously administered via catheter to test group 0.5 ml/kg saline comparison group. A control comprised sham-operated that not injected any drugs other than anaesthesia during...
The purpose of the study was to evaluate clinical significance CNS biological markers in an ischemic stroke. Materials and methods . Blood serum biomarkers were assayed by ELISA patients suffering from cerebrovascular disorders origin. Neuron-specific enolase, brain-derived neutrophic factor (BDNF), glial-derived (GDNF), protein S-100 total (ɑβ–ββ), sialyl carbohydrate antigen (KL-6), vascular endothelial growth factor, superoxide dismutase analyzed. All tests carried out using automatic...
Aim. To study the clinical effectiveness of patient-oriented therapy in polymorbid patients with arterial hypertension (HT) comparison conventional by assessment rationality (secondary combined endpoint) and total mortality (primary endpoints). Material methods. Dynamics were evaluated a circular prospective 1000 HT under or therapies. Results. The strategy demonstrated statistically significant advantage over criterion secondary endpoint, starting from 24 week (Student's t-test: p=0.049 at...
Intense physical activity increases the risk of sudden death by 10–17 fold. Some most important tasks modern pathophysiology in sports medicine include searching for factors that allow an athlete’s body to adapt loads, understanding line between adaptation and pathology identifying groups failure. It is necessary distinguish hypertrophic cardiomyopathy true myocardial hypertrophy athletes results from cardiovascular system intense exertion. In Seattle, American Medical Society Sports...
INTRODUCTION. Due to the demographic aging of population, problem treatment age-related diseases and prevention premature in modern healthcare has become particularly urgent. One most promising approaches is impact on molecular mechanisms aging, including activation adaptive systems suppression pathological processes body. Methods extracorporeal hemocorrection have proved be a good idea this respect. AIM. To evaluate effectiveness safety hardware plasmapheresis as technology for correcting...
Materials and methods. The article presents the results of laboratory tests for presence IgG antibodies to SARS-CoV-2 coronavirus in 2112 patients living 5 regions Russian Federation. In main group study, 50 people were under dynamic observation 6 months. Depending on severity, was divided into two subgroups: I1 (n=25), represented by with moderate infection, I2 consisting a severe course infection. Blood sampling carried out 14th day illness (from moment first symptoms appeared) conditions...
The aim of the study was to identify role cytokine storm in COVID-19, that emerged at end 2019, based on analysis 80 publications, including 17.4% Russian and 82.6% foreign publications for 2014–2020 with an average impact factor 11.94 a maximum 74.699. This review includes in-depth discussion possible causes pathogenetic factors syndrome development caused by COVID-19. results research use various principles correction are provided. It has been established lung damage fatal outcome not...
Abstract The ongoing COVID-19 pandemic calls for more effective diagnostic tools, and T cell response assessment can serve as an independent indicator of prior exposure while also contributing to a comprehensive characterization SARS-CoV-2 immunity. In this study, we systematically assessed the immunogenicity 118 epitopes with immune cells collected from multiple cohorts vaccinated, convalescent, healthy unexposed exposed donors. We identified seventy-five immunogenic epitopes, 24 which were...
BACKGROUND: The most common diagnosis given to patients with chronic urticarial rashes is spontaneous urticaria (prevalence in the population 0.1–1.4%). However, similar symptoms can also be observed other rarer diseases: vasculitis, hypocomplementemic vasculitis syndrome, cryopyrine-associated syndromes and Schnitzler's syndrome.
 AIM: analyze clinical features histological characteristics of skin biopsies optimize management improve differential diagnosis.
 MATERIALS AND METHODS:...
Resistin is a cysteine-rich secretory protein. This protein expressed in various human organs and tissues, including white adipose tissue, lung, spleen, adrenal gland, pituitary hypothalamus, intestinal epithelium, placenta, pancreas, stomach, skeletal muscle, skin plasma. expression increases during the differentiation of monocytes into macrophages induced by proinflammatory cytokines such as IL-1, IL-6, IL-12 TNF-a. After translation, resistin stored on neutrophil membrane, well...
To reveal pathological lung changes in baclofen poisoning and to assess their dynamics.
To study the histological changes in lung of rats, evaluate their dynamics and determine Bax Bcl-2 genes expression bronchial epithelium, alveolar type 1 cells neutrophils at different times after administration baclofen.
Backgraund: Baclofen is a selective GABAB agonist, which has pronounced psychotropic effect and often the subject to abuse. The of baclofen on cardiovascular respiratory systems not been studied. Aims: aim study was assess dynamics some functional parameters lung histopathology in baclofen-ethanol poisoning. Materials methods: Balofen its combination with ethanol were administered rats under general anesthesia (chloral hydrate). controls (n=5) treated or ethanol. Group 1, 3, 5 animals (85...
In the review of current literature urgent issues treatment patients with atrial fibrillation are analyzed, namely prevention thrombosis and use anticoagulants therapy. The article describes possibilities thromboembolic complications in at high risk. fact insufficient preventive antithrombotic therapy thrombotic risk is demonstrated, which associated both incomplete adherence doctors to implementation clinical recommendations, low receiving prescribed anticoagulants. discusses difficulties...
The aim is to study the effectiveness of lithium chloride for preventing damage monolayer endothelial cells in vitro exposed serum patients with septic shock. Material and methods. Serum samples prepared from blood 5 shock selected according «Sepsis-3» criteria healthy volunteers (control serum) were used study. Blood experiments was withdrawn within 2 hours after diagnosis Ea.hy926 incubated a patient (toxic or control 3 at 37°C without final concentrations 0.01 mmol/l, 0.1 1 10 mmol/l....