This is the first in vivo study to investigate neuroprotective effects of krypton on focal cerebral ischemia. The aim was analyze effect 2 h inhalation a krypton–oxygen mixture (Kr 70%/O2 30%) recovery neurological functions and degree brain damage rats after photoinduced ischemic stroke (PIS) possible mechanisms responsible for this neuroprotection. Experiments were performed male Wistar weighing 250–300 g (n = 32). Animals randomized into four groups. Two groups 20) underwent stroke,...

The aim of the study was to compare effect sevoflurane and chloral hydrate on neurological status volume brain damage after trauma ischemia in experimental models traumatic injury (TBI) focal ischemic stroke (IS) induced by photothrombosis (PT). Materials methods . experiments were performed mongrel Wistar rats weighing 250–300 g (N=43). There 4 groups: Ischemia + Sevoflurane group (ISSEV) (N=10), Chloral (ISCH) TBI (TBISEV) (N=13), TBI+Chloral (TBICH) (N=10). Ischemic modelled using Rose...

In vivo studies of the therapeutic effects argon in traumatic brain injury (TBI) are limited, and their results contradictory. The aim this study was to evaluate effect a three-hour inhalation (70%Ar/30%O2) after an open TBI on severity neurological deficit degree damage rats. experiments were performed male Wistar rats (n = 35). simulated by dosed contusion injury. animals divided into three groups: sham-operated (SO, n 7); + 70%N2/30%O2 (TBI, 14); 70%Ar/30%O2 (TBI iAr, 14). Neurological...

Aim of the study . To determine effects xenon exposure at a dose 0.5 MAC different duration on content and enzyme-inactivating phosphorylation glycogen synthase kinase-3β (GSK3β) in perifocal zone ischemic cerebral infarction an experimental setting. Materials methods The Long method was used for modelling brain ischemia/reperfusion 39 rats weighing 300-350 g. Study group animals exposed to during 30, 60 120 minutes whereas control received oxygen-air mixture. Sham-operated served as...

The purpose of this review the 81 publications is to discuss current national and international data on prediction neurological outcomes after sudden circulatory arrest (SCA) using molecular biomarkers. discusses state problem a arrest, principal therapeutic measures improve these currently available clinical, laboratory, instrumental methods diagnosis arrest.

Acute ischemic stroke is a serious problem for healthcare systems worldwide. Searching the optimal neuroprotector contemporary challenge. Various studies have demonstrated neuroprotective properties of argon in brain damage models. However, published data are inconsistent. The aim study was to evaluate effect 24-hour argon-oxygen mixture (Ar 70%/O ₂ 30%) inhalation on severity neurological deficit and extent rats after photoinduced stroke. Material methods. experiments were carried out male...

INTRODUCTION: Severe combined trauma remains the leading cause of mortality and disability workable population. Under damaging factor influence, a whole cascade pathological processes is triggered, to development multiple organ failure. OBJECTIVE: Exploration effects synthetic analogue tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate (Dalargin) on dynamics oxidative stress markers in patients with severe polytrauma dysfunction. MATERIALS AND METHODS: 104 were included study....

Purpose of the study. To evaluate influence sublethal dose Clozapine on functional and morphological parameters cardiovascular system in rats 4 hrs. after drug administration. Materials methods. The experiments were carried out male Wistar weighing 200–250g ( n =14). Group I received 0.9% NaCl solution administered via enteral feeding tubing under general anesthesia using Sevoflurane; group II — dosed at 150 mg/kg solution; III 40% ethyl alcohol solution. administration, arterial blood...

<h3>ЦЕЛЬЮ</h3> Обзора является анализ данных литературы о перспективах и безопасности продленной седации ингаляционными анестетиками с применением устройства для ингаляционной испарителя AnaConDa в отделениях интенсивной терапии реанимации. Анализ результатов исследований показал, что применение отделении реанимации пациентам, находящимся критическом состоянии, способствует ранней активизации реабилитации благодаря хорошей управляемости, сокращает время пребывания на искусственной вентиляции...

The aim of the study. To study effect ley-enkephalin synthetic analogue on dynamics inflammatory response markers and organ dysfunction in patients with severe combined trauma. Materials methods . A prospective clinical historical control from two centers — N. I. Pirogov State Clinical Hospital No. 1 N.V. Sklifosovsky Research Institute for Emergency Medicine included men women trauma ISS scores values 18–44, aged 18 to 70 years. Diagnostic therapeutic approaches all followed current...

The study aims to evaluate the efficacy of xenon inhalation at various concentrations on neurological and cognitive impairments when simulating open traumatic brain injury (TBI) in rats. Tests were performed 35 male Wistar rats weighing from 250 350 g. After an injury, animals received with a mixture gases: 5 sham operated only anesthesia without inhalations, control group + N2 70 % / O2 30 (group “TBI”, n = 10); experimental xenon-oxygen “TBI iXe70”, 10), nitrogen – Xe %, iXe N2”, 10) for...

The noble gas argon is one of the most promising neuroprotective agents for hypoxic-reperfusion injuries brain. However, its effect on traumatic has been insufficiently studied. aim this study was to analyze triple inhalation argon-oxygen mixture Ar 70%/O2 30% physical and neurological recovery degree brain damage after injury investigate possible molecular mechanisms effect. experiments were performed in male Wistar rats. A controlled model used effects treatment underlying mechanisms....

The study aims to assess the effect of a two-hour inhalation with krypton and oxygen mixture following photo-induced cerebral infarction simulation on manifestation neurological deficits degree brain injury in rats. tests were conducted male Wistar rats weighting 250 300 g (n = 20). Following simulation, rodents underwent nitrogen N2 70%/O2 30% (group Nitrogen; n 10) or gas Kr Krypton; for two hours. For next 14 days, examined. On 3rd, 7th, 14th authors performed test Limb placement, as well...

One of the main problems facing intensivists when treating patients with COVID-19 is severe and critical acute respiratory distress syndrome (ARDS) underlying viral pneumonia. The current guidelines Russian Ministry Health (Version 15 22.02.22) do not include drugs a lung protective effect. This issue could be solved by administration synthetic analogue leu-enkephalin. Aim. Study efficacy leu-enkephalin in ARDS COVID-19. Materials methods. study included 35 divided into 2 groups. Group 1...

Aim of the study : to investigate chest compression parameters by city hospital staff under simulated conditions with and without use a sensor device for quality control compressions. Materials Methods . The was conducted in Moscow's multidisciplinary hospitals. included 359 medical members. participants were divided into 4 groups: physicians ( n =97) nurses =82) from intensive care units (ICU) =92) =88) specialized departments. Participants performed 2 minutes compressions (CCQC) sensor,...

Aim. to assess galectin-3 level in the serum of HCV patients according biochemical activity hepatitis, liver fibrosis, view insulin resistance and overweight. Materials methods: The content was detected 78 with chronic hepatitis C age from 20 55 years oligosymptomatic course disease minimally expressed fibrosis most cases. We evaluated association between blood metabolic disorders, liver. Results: In normal ALT levels (42% patients), average galectin 3.17 (1.23; 5.94) ng / ml. Elevated...

Aim of the study : to evaluate effect sublethal dose clozapine on rat cardiovascular system 24 hours after administration drug. Materials and methods . The experiments were carried out 17 male Wistar rats weighing 220-270 g. Under general anesthesia with sevoflurane, animals Group I enterally given 0.9% NaCl solution, II received in a 150 mg/kg diluted 2.0 ml solution 0.9%, III 40% ethanol. Blood pressure (BP), heart rate (HR), skin microcirculation using laser Doppler flowmetry (LDF), NADH...

The aim is to study the current aspects of resident training in anesthesiology and intensive care. article focuses on theoretical residents, importance a thorough knowledge pathophysiology, formation clinical thinking. Opportunities for use innovative educational computer technologies residency are shown. A consistent interdisciplinary pedagogical interaction makes it possible improve outcomes by achieving main goal developing physician who has acquired universal, general specific...