Lithium salts are known to treat bipolar disorder. Their high potential as neuroprotective agents in cerebral ischemia determines relevance for preclinical studies the registration of new drugs based on them. Aim study was investigate toxic properties and local tolerability with an assessment toxicokinetics developed lithium chloride preparation injection dwarf pigs repeated intravenous administration. Material methods . (solution, administration 4.2 %) has been administered minipigs...

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may be a critically important method for supporting patients with acute STsegment elevation coronary syndrome (STEMI) undergoing percutaneous intervention (PCI) in high-risk settings. Objective: to demonstrate the effectiveness of ECMO patient severe cardiovascular insufficiency against background myocardialischemia conditions ongoing intensive care Clinical observations: case use VA-ECMO before PCI 63-year-old multiple occlusive...

This report describes two clinical cases involving prolonged inhalation sedation using the AnaConDa device in ICU. Both patients achieved and maintained adequate levels throughout treatment period. No significant adverse cardiovascular effects were observed.

High concentration of sepsis-associated aromatic microbial metabolites (AMM) stands as a prognostically unfavorable factor, indicating the progression multiple organ dysfunction and an increased risk death in patients with sepsis septic shock. This study is based on hypothesis that excess AMM caused by metabolic alterations (dysfunction) intestinal microbiota. The aim this was to compare potential normobiota pathobiota bio-transform amino acids tyrosine phenylalanine, such phenyllactic...

The review deals with the mechanisms of action opioids and synthetic analogue endogenous leuenkephaline dalargin. It discusses relation delta-opioid receptors to phenomenon pharmacological preconditioning that may explain universal cytoprotective properties dalargin observed in clinical observations. Key words: opioids, opioid receptors, preconditioning, cytoprotection,

Purpose: to determine the informative value of prediction mortality patients with sepsis using a combination candidate markers — quantitative content circulating cell-free DNA (cfDNA) in plasma and allelic variants TLR9 gene encoding-cellular recognition receptor for fragments. Materials methods. The study included from five ICU 4 four hospitals ( n =156). were divided into 2 groups: (1) (based on SEPSIS-3, 2016, criteria), =81) acute cerebrovascular event =75). CfDNA was isolated patient's...

BACKGROUND: Analgesia is crucial in the treatment of patients with acute pancreatitis, which includes increased use regional analgesia. In recent years, less-invasive and safer methods pain relief, particularly erector spinae plane block (ESP-block), has drawn attention from anesthesiological community. However, studies on its pancreatitis are rare. OBJECTIVE: Our aim was to make a clinical evaluation bilateral pancreatitis. MATERIALS AND METHODS: A pilot prospective randomized study...

Objective: to investigate the activity of sevoflurane, dalargin, and lithium chloride in protecting rat brain from total ischemia/reperfusion define whether GSK=3^ deposphorylation contributes mechanism pharmacological preconditioning. Materials methods. Experiments were carried out on 80 male albino rats which temporary circulatory arrest (CA) was simulated by ligating cardiovascular fascicle for 10 20 minutes. The animals revived mechanical ventilation external cardiac massage,...

2 0 1 3 , I X ; 4 30 www.niiorramn.ruЦель исследования -оценить выраженность кардиопротекторных свойств севофлурана и пропофола в остром экспе рименте на крысах после тотальной ишемии/реперфузии при их раздельном совместном применении.Материалы методы.Исследование выполнено 50 самцах белой беспородной крысы весом 202±19 г (M±σ σ) с использование модели (И/Р).Случайным образом сформировано 5 групп: я -хлоралгидрат 300 мг/кг внутрибрюшинно, ИВЛ 15 минут. -ингаляционная индукция севофлураном...

Purpose of the study: to investigate epidemiology sepsis in patients with different locations infection focus, who were admitted intensive care unit (ICU) a multi-specialty hospital 2014 and 2016. Material methods. A retrospective analysis examination treatment 860 ICU diagnosis ‘sepsis’ 2016 was carried out. Sepsis diagnosed pursuant Sepsis-2 Guidelines verified by blood procalcitonin test. The gender, age, main diagnosis, patient’s severity at time admission ICU, duration peculiarities...

In addition to high mortality, craniocerebral injuries have another danger, a long rehabilitation period and percentage of disability with the development cognitive impairment. This is primarily associated processes neuroinflammation, which development, according recent data, leads long-term impairment consciousness. The anti-inflammatory effects xenon inhalation anesthetic, been repeatedly shown in previous studies, potential beneficially affect level consciousness these patients by...

ABSTRACTS Ischemic stroke occupies a leading position among the causes of mortality and disability. Long-lasting motor cognitive impairments, decrease in level consciousness over time aggravate course disease, to immobilization syndrome comorbidity load, which contributes development life-threatening conditions this category patients. In regard, search for new neuroprotective strategies used at an early stage capable minimizing severe consequences patient particular society as whole seems...

Aquaporins 4 and 5 are proteins that form water channels in the cell membrane, participate transfer migration of immune cells, being expressed on many types including CNS astrocytes, kidney lungs, system. We have previously shown AQP genetic polymorphism is associated with different outcomes abdominal sepsis. Since another common aquaporin protein, 4, also surface immunocompetent determining motility, it was suggested may be important pathogenesis sepsis, predetermine sepsis severity...

Background. The syndrome of systemic inflammatory response, which underlies the damaging effect factors infectious and non-infectious genesis, may cause multiple organ failure. degree its severity is determined, among other things, by activation neutrophils. paper highlights new mechanisms anti-inflammatory action inhalation anesthetic xenon, mediated a decrease in ability neutrophils to pro-inflammatory response. Aim study. To evaluate xenon on human under ex vivo conditions. Material AND...

Objective: to provide a rationale for the efficiency of sevoflurane-induced cardiac preconditioning (CPC), by assessing pattern recovery heart rate and estimating troponin I levels changes in NT-proBNP concentrations patients undergoing aortocoronary bypass surgery (ACBS) under extracorporeal circulation (EC). Subjects methods. Sixty aged 60.6±8 years (M±&) were examined after elective ACBS using EC divided into two groups 30 each: 1) inhalation induction maintenance anesthesia (IIMA)...

The leading role of neuroinflammation as the culprit a long-term impairment consciousness in patients after injuries to central nervous system forces us look for new effective strategies resolving this pathological process. Xenon reducing intensity inflammatory response due impact on several links is potentially able have beneficial effect category patients. Using laboratory equipment, we evaluated half-hour daily inhalations 30% air mixture with xenon 7 days level markers neuronal damage...

Currently, a number of experimental studies have demonstrated compelling evidence neuro-, cardio-, and nephroprotective properties medications containing lithium chloride. Aim the study . To evaluate effect various concentrations chloride on ischemic stroke volume perifocal edema in rats after cerebral ischemia. Material methods Male mongrel weighing 315±13.5 g were used study. The focal ischemia model according to Longa et al. was employed. animals ( n =35) divided into 5 groups:...

The researcher's opinions about myocardial and brain anesthetic preconditioning efficiency are yet contradictive. In addition, the neuroprotection phenomenon is poorly investigated. this study authors attempted to evaluate of central nervous system (CNS) protection by using a modified method volatile induction maintenance anesthesia (VIMA) based on pulse-like sevoflurane dosing that excludes propofol usage. Ninety CABG patients aged 45-75 years were included in group underwent with (2 MAC)...

Aquaporins represent proteins contributed to water transport through cell membrane. They are involved in formation and resolution of edema, migration fl ammatory reaction. There only few studies linking the genetic polymorphism aquaporin 5 (rs3759129 AQP5) sepsis. At same time, apparent heterogeneity patients along foci infection may limit fi nding most signi cant association AQP5 genotypes with course infectious complications critical conditions restrict further development rs3759129 as a...

<h3>ЦЕЛЬЮ</h3> Обзора является анализ данных литературы о перспективах и безопасности продленной седации ингаляционными анестетиками с применением устройства для ингаляционной испарителя AnaConDa в отделениях интенсивной терапии реанимации. Анализ результатов исследований показал, что применение отделении реанимации пациентам, находящимся критическом состоянии, способствует ранней активизации реабилитации благодаря хорошей управляемости, сокращает время пребывания на искусственной вентиляции...

The purpose of this study is to determine and evaluate if the preconditioning with desflurane depends on level phosphoGSK3β. Material methods . White outbred male rats (56) were randomly allocated 6 groups. Ischemia/reperfusion modeling was performed using V. G.Korpachev's technique. reference group consisted sham (falselyoperated) animals. second underwent global ischemia/reperfusion after anesthesia chloral hydrate. next two groups treated either sevoflurane or at 1 MAC. In final groups,...

The aim of the study. To study effect ley-enkephalin synthetic analogue on dynamics inflammatory response markers and organ dysfunction in patients with severe combined trauma. Materials methods . A prospective clinical historical control from two centers — N. I. Pirogov State Clinical Hospital No. 1 N.V. Sklifosovsky Research Institute for Emergency Medicine included men women trauma ISS scores values 18–44, aged 18 to 70 years. Diagnostic therapeutic approaches all followed current...