A5060244014- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Neurological Disorders and Treatments
- Heart Rate Variability and Autonomic Control
- Clinical Nutrition and Gastroenterology
- Respiratory Support and Mechanisms
- Nutrition and Health in Aging
- Infrared Thermography in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Bacteriophages and microbial interactions
- Diet and metabolism studies
- Healthcare Systems and Public Health
- Neuroscience of respiration and sleep
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Human Mobility and Location-Based Analysis
- Circadian rhythm and melatonin
- S100 Proteins and Annexins
- Burn Injury Management and Outcomes
- Liver Disease and Transplantation
Peoples' Friendship University of Russia
2015-2025
V.A. Negovsky Scientific Research Institute of General Reanimatology
2018-2024
Deleted Institution
2024
St. Cyril and St. Methodius University of Veliko Tarnovo
2023
Altai State Agricultural University
2021-2022
Russian Academy of Sciences
2018-2022
Resuscitation Council
2020
ITMO University
2016-2019
Russian New University
2018
National Sports Academy Vassil Levski
2017
Meropenem is a widely prescribed β-lactam antibiotic. exhibits maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant drug levels above the minimal inhibitory concentration. Compared with intermittent administration, administration of meropenem may improve clinical outcomes.To determine whether reduces composite mortality and emergence pandrug-resistant or extensively drug-resistant bacteria compared in critically ill patients sepsis.A double-blind, randomized...
After discharge from the Intensive Care Unit (ICU), more than 50 % of patients experience pathological symptoms that are not related to primary emergency but reduce quality life and require rehabilitation. Post Syndrome (PIСS) include only those conditions do have a direct causal relationship with condition gave rise hospitalization in ICU. The pathophysiological basis PICS is phenomenon “learned non-use”: state artificial limitation patient’s motor cognitive activity as result use...
BACKGROUND: Introduction of new methods improving the rehabilitation effectiveness in patients after ischemic stroke (IS) still remains a relevant area. Encouraging experimental data revealing neuroprotective effects hypothermia, as well positive Craniocerebral Hypothermia (CCH) use during acute period provided basis for this study. AIM: This study aims to evaluate CCH method patient’s early recovery IS. MATERIALS AND METHODS: The single-center prospective pilot included 95 (70 main group...
The study of predictors adverse outcomes in liver failure is driven by the rapid increase patients with obstructive jaundice (OJ) and lack standardized diagnostic criteria for assessing functional status. Aim. To investigate changes injury biomarkers associated OJ. Materials Methods. A prospective observational cohort was conducted on serum — L-FABP protein, 5'-nucleotidase, arginase, hyaluronic acid due to benign included 53 who underwent biliary decompression. Based course disease, were...
Performance of healthcare can be measured as its ability to restore and preserve health with acceptable costs for the society. Under current prevalence chronic disease, medical care (the major content healthcare) underperforms in all key indicators: clinical effectiveness, benefit/risk ratio interventions, cost/benefit ratio, general population health. In Russia performance indicators (KPI) do not allow effective decision-making; a similar situation is seen worldwide: most KPIs are either...
Introduction. To date, patients with chronic disorders of consciousness (CDC) represent a serious problem from the medical, social, and economic points view. Because relatively small incidence this condition, accumulation sufficient experience in its diagnosis treatment remains complex task, while lack unified approach among Russian specialists to classification CDC makes it even harder solve. At same time, there are widely used terms overseas that accepted by medical community current...
The emergence of SARS-CoV-2 and its worldwide spread has become a challenge for healthcare professionals related to rapid diagnosis infection caused by the new coronaviruses, provision specialized medical care, rehabilitation secondary prevention. Currently, there is limited information on primary, prevention this disease. most common clinical manifestation variant coronavirus bilateral pneumonia, with 34% patients developing acute respiratory distress syndrome (ARDS). Given unusual pandemic...
This work aims to evaluate the prognostic value of demographical and clinical data on long-term outcomes (up 12 months) in patients with severe acquired brain injury vegetative state/unresponsive wakefulness syndrome (VS/UWS/UWS) or a minimally conscious state (MCS). Patients (n = 211) VS/UWS/UWS 123) MCS 88) were admitted Federal Research Clinical Center Intensive Care Medicine Rehabilitology after anoxic 53), vascular lesions 59), traumatic 93), other causes 6). At beginning 12-month...
Increasing evidence suggests that gut dysbiosis is associated with coronavirus disease 2019 (COVID-19) infection and may persist long after resolution. The excessive use of antimicrobials in patients COVID-19 can lead to additional destruction the microbiota, as well growth spread antimicrobial resistance. problem bacterial resistance antibiotics encourages search for alternative methods limiting restoring normal balance microbiota human body. Bacteriophages are promising candidates...
Spinal cord stimulation (SCS) is one approach to the potential improvement of patients with post-stroke or post-traumatic spasticity. However, little known about whether and how such interventions alter supraspinal neural systems involved in pathogenesis This pilot study investigated epidural spinal at level C3-C5 cervical segments, aimed reducing spasticity, alters patterns functional connectivity brain.
Chronic disorders of consciousness (DOC) represent severe central nervous system damage resulting in long-term disability and a significant burden to healthcare institutions patientsʼ families. DOC develop patients after coma are characterized by the presence wakefulness with complete or almost absence signs awareness. include vegetative state (VS) minimally conscious (MCS). The term prolonged (pDOC) is also used Russian literature describe initial stages chronic DOC. Another clinical...
Advances in intensive care have enabled patients to survive an acute critical condition, producing a growing population of chronic condition with long-term dependence on care. These make up 5–10% all respiratory failure and require disproportionate share resources the units, overall yearly survival rate 40–50%. The aim review is identify impact comorbid complications course outcome severe brain injury. Ninety-six sources were selected according data characterizing clinical (syndromic) model...
The review focuses on the neuroprotective mechanisms of therapeutic hypothermia from standpoint metabolic depression and genomic reprogramming neurons that develop when brain temperature decreases. concept hypothermic pre-conditioning based development typical nonspecific reactions for formation cytoprotective phenotype due to potentially dangerous stimuli, such as ischemia, reperfusion, hypothermia, was used explain effects low temperatures. data confirming role cerebral a technique...
The prevalence of stroke-induced cognitive impairment is high. Effective approaches to the treatment these impairments after stroke remain a serious and perhaps underestimated challenge. A BCI-based task-focused training that results in repetitive recruitment normal motor or circuits may strengthen stroke-affected neuronal connectivity, leading functional improvements. In present controlled study, we attempted evaluate modulation under influence 10 days P3-based BCI speller subacute ischemic...
The temperature of the brain can reflect activity its different regions, allowing us to evaluate connections between them. A study involving 111 patients in a vegetative state or minimally conscious used microwave radiometry measure their cortical temperature. were divided into main group receiving 10-day selective craniocerebral hypothermia (SCCH) procedure, and control basic therapy rehabilitation. showed significant improvement consciousness level as measured by CRS-R assessment on day 14...
The objective was to develop a predictive model for assessing the risk of hospital mortality in patients with COVID-19-associated acute respiratory distress syndrome (ARDS) treated veno-venous extracorporeal membrane oxygenation (VV-ECMO). Materials and methods. We carried out analysis case histories 123 ICU № 7 Moscow City Clinical Hospital 52 during COVID-19 pandemic period. All were VV-ECMO ARDS according current indications. analyzed characteristics potentially associated mortality,...
Aim. To evaluate the safety and efficacy of adaptive phage therapy technique in patients with recurrent pneumonia neurological critical care. Material methods. The clinical study included 83 chronically critically ill severe brain damage. bacteriophage cocktail selected against specific hospital strains was administered by inhalation to 43 patients. control group 40 who received conventional antimicrobial therapy. changes clinical, laboratory instrumental parameters, levels biomarkers,...
Abstract In this study, the current situation in agricultural sector of Kazakhstan and specifically diary sphere is analized. Innovations technologies for dairy industry are also being researched, possibility their utilization proposed, along with ways to further development. This study shows largest enterprises Republic Kazakhstan, production capacities, methods milk production. It presents innovative that improve process as well its quality quantity. reveals problems lack acreage, absence...
Nowadays there is a growing interest worldwide in using bacteriophages for therapeutic purposes to combat antibiotic-resistant bacterial strains, driven by the increasing ineffectiveness of drugs against infections. Despite this fact, no novel commercially available phage products have been developed last two decades, as it extremely difficult register them under current legal regulations. This paper presents description interaction between bacteriophage manufacturer and clinical...