A5073299255- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- Healthcare Systems and Public Health
- Respiratory Support and Mechanisms
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Technology and Human Factors in Education and Health
- SARS-CoV-2 and COVID-19 Research
- Neurosurgical Procedures and Complications
- Ultrasound in Clinical Applications
- Thermal Regulation in Medicine
- Burn Injury Management and Outcomes
- Mechanical Circulatory Support Devices
- Electrochemical sensors and biosensors
- Intracerebral and Subarachnoid Hemorrhage Research
- Esophageal and GI Pathology
- Anesthesia and Neurotoxicity Research
- Heart Rate Variability and Autonomic Control
Research Institute of Emergency Care
2016-2025
Moscow State University of Medicine and Dentistry
2014-2025
Ministry of Health of the Russian Federation
2018-2021
Moscow State University of Psychology & Education
2021
The article presents the results of a synthesis by Australian and Canadian scientists (Kisely et al, 2020) 59 reliable studies effects work during various epidemics, including COVID-19, on mental health well-being medical workers in different countries research includes level professional burnout, symptoms emotional ill-being, distress data based analysis sample from 248 involved healthcare professionals Russian institutions They anonymously voluntarily filled up Google-form that contained...
After discharge from the Intensive Care Unit (ICU), more than 50 % of patients experience pathological symptoms that are not related to primary emergency but reduce quality life and require rehabilitation. Post Syndrome (PIСS) include only those conditions do have a direct causal relationship with condition gave rise hospitalization in ICU. The pathophysiological basis PICS is phenomenon “learned non-use”: state artificial limitation patient’s motor cognitive activity as result use...
The aim of this study was to identify single nucleotide variants in genes associated with susceptibility or severe outcomes COVID-19. A total 319 genomic DNA samples from patients varying degrees disease severity and 78 control people who had regular prolonged contact COVID-19 but did not have clinical manifestations and/or antibodies SARS-CoV-2. Seven SNPs were identified that statistically risk course, rs1799864 the CCR2 gene (OR = 2.21), rs1990760 IFIH1 2.41), rs1800629 TNF 1.98),...
Secondary vascular spasm due to non-traumatic rupture of cerebral artery aneurysms is a formidable complication leading serious disability patients who face this disease, and in 30–50% cases leads death. Standard therapy used intensive care units does not have tremendous success the treatment pathology, which encourages scientists around world search for new drugs that can improve outcome increase quality life patients. At moment, most promising non-surgical method use nitric oxide donor as...
INTRODUCTION The main reasons for the unsatisfactory outcome of surgical treatment patients with non-traumatic subarachnoid hemorrhage (SAH) due to ruptured cerebral aneurysms are vascular spasm (VS) and delayed ischemia. Lysis blood clots in space leads release a large number various vasoactive factors that stimulate cytotoxic, inflammatory reactions oxidative stress, which may be one development VS secondary ischemic brain damage. THE AIM OF STUDY Study dynamics stress indicators...
Background. Patients with deep burns require surgical treatment, but the timing and scope of interventions have not yet been defined. Objective. To analyze world experience treatment burns. Material methods. The literature sources on topic were searched for in electronic databases: PubMed, Scopus, CrossRef period from 1947–2023. work includes some early basic publications burns; current state problem has analyzed articles over past 20 years. Conclusion. Data foreign show that low-income...
Abstract . In the context of pandemic, when healthcare professionals are forced to work under extreme stress and an increased threat infection, research on professional burnout emotional maladjustment medical workers is gaining particular relevance around world. Aim study To assess severity symptoms depression anxiety, distress among employees N.V. Sklifosovsky Research Institute for Emergency Medicine, providing care patients with COVID-19 in current period (July). compare them indicators a...
The most important factor in improving the quality of medical services at present is continuous improvement all aspects activities a organization, which determines appropriateness using modern approaches to organizational development institutions with their appropriate adaptation. paper presents results analysis 16 known models development, as well performance indicators Kaidzen proposal system 19 Russian and foreign enterprises various industries. An authors’ long-term experience working...
The SOFA scale should be used to predict the outcomes of thermal injury. Objective. To study possibilities in predicting injury stratification groups revised Frank index (RFI). Material and methods. A retrospective included 196 patients stratified into 3 groups: RFI≤70 (54 patients, all survived), RFI 71—180 (120 patients: 96 survived, 24 died), RFI≥181 (22 died). We analyzed scores within days after (SOFA1, SOFA2, SOFA3) compared three by including between with survivors 71—180, deceased...
More than 30% of patients with skin burns have inhalation injury (InI). InI worsens clinical status and increases the risk death. Not all prognostic burn indexes include or do not adequately assess severity. Validity patient stratification models based on indices was studied in samples simultaneously consisting without InI. Objective. To validity relation to mixed samples. Material methods. The study included 399 burns. Of these, there were 140 (35%) ones There 283 (71%) men. Age 50 (36; 66)...
Disruption of intestinal homeostasis is a leading factor in the pathogenesis and progression systemic inflammation patients with acute severe pancreatitis. The development complications occurs due to both mesenteric hypoperfusion dysregulation motility, as well destruction barrier, translocation bacterial bodies their substrates. This increases risk developing multiple organ failure increased mortality. With advent high-throughput sequencing methods for microbiome samples, example, 16S rRNA...
OBJECTIVE . Assessment of patients with impaired consciousness is a priority task in the department intensive care. The Glasgow Coma Scale (GCS), which includes assessment motor , speech and ocular reactions, was first scale developed for this purpose. absence versions GCS that passed validation research, reduces quality its application Russia other Russian-speaking countries limits possibility obtaining objective clinical results during evaluation reduced level wakefulness, significantly...
RELEVANCE . Patients with a systemic reaction to inflammation are often observed after adequate surgical intervention and/or treatment of the underlying disease. Laboratory tests indicate presence pronounced inflammatory process, and instrumental diagnostic methods (ultrasound, computed tomography, radiography) do not always help in detecting source inflammation. THE AIM OF STUDY Is present possibilities radionuclide imaging (RI) using labelled autologous leucocytes identify infection....
RELEVANCE . Diaphragmatic dysfunction (DD) is common in critically ill patients, and often the cause of respiratory failure requiring support. A generally accepted method for noninvasive dynamic evaluation diaphragm function has not yet been proposed. AIM OF STUDY To develop a ultrasound examination mobility relative thickening, to propose standard parameters excursion thickening depending on gender age. MATERIAL AND METHODS In 81 healthy volunteers aged 25 84 years (mean age 55±15 years),...
The choice of treatment tactics for a patient with burns should be based on individual prediction injury outcome. Known models predicting the outcome burn are inaccurate and do not allow us to determine probability different outcomes particular patient. AIM OF THE STUDY . To develop method mathematical model using revised Frank index. MATERIAL AND METHODS 399 patients: men 283 (71%), women 116 (29%); age — 50 (36; 66) years; total area 25 (15; 40) % TBSA, I–II degree 20 (10; 30) III 8 (3;...
Objective. To investigate the influence of arterial hypertension (AH) and ischemic heart disease (IHD) on course outcomes COVID19, considering their various stages, forms, target organ involvement. Materials мethods. A total 808 COVID19 patients hospitalized in Intensive Care Unit (ICU) from October 1 to December 31, 2020, aged between 17 97 years, were examined. The first group consisted 246 without comorbidities. second included 430 with AH: 305 stage II 125 III. third comprised 132 IHD 84...
Objective. To improve treatment outcomes in patients with obstructive jaundice at the flagship center through distributing patient flows and applying optimal tactics. Material methods. A retrospective study included between January 2022 April 2024. Patients were divided into 2 groups: main group — hospitalized March 2023 2024 (the first year of work center); control February (one before commissioning center). In both groups, we analyzed gender- age-adjusted distribution patients, channels...
Introduction. To date, patients with chronic disorders of consciousness (CDC) represent a serious problem from the medical, social, and economic points view. Because relatively small incidence this condition, accumulation sufficient experience in its diagnosis treatment remains complex task, while lack unified approach among Russian specialists to classification CDC makes it even harder solve. At same time, there are widely used terms overseas that accepted by medical community current...
Aim. To evaluate dynamic changes in the lungs, hemostasis system, immune system different terms after coronavirus pneumonia. Materials and methods. Ventilation-perfusion single-photon emission computed tomography/computed tomography (CT), functional methods of lung investigation, evaluation status specific humoral response were performed evaluated A total 71 patients examined according to this protocol. We with lesion volume not less than 50% chest CT. All divided into 2 groups depending on...
Background. The paper discusses the use of a thermal helium-oxygen mixture (t-Не/О2 ), novel technology, in treating patients with 2019-nCoV acute respiratory disease (COVID-19) who develop life-threatening failure.
 Aim to evaluate safety and efficacy t-Не/О2 inhalation combined standard therapy treatment failure COVID-19.
 Materials Methods. This was single-center, randomized, prospective study 70 COVID-19. All were divided into two groups: Group 1 (n = 38) received t-He/О2...
Background and objectives COVID‐19 convalescent plasma is an experimental treatment against SARS‐CoV‐2. The aim of this study to assess the impact different pathogen reduction methods on levels virus neutralizing activity specific antibodies SARS‐CoV2 in plasma. Materials A total 140 doses collected by plasmapheresis from donors were subjected three methods: methylene blue (M)/visible light, riboflavin (R)/UVB amotosalen (A)/UVA. To conduct a paired comparison, individual divided into 2...