A5074919240- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders Research
- Viral Infectious Diseases and Gene Expression in Insects
- Nanowire Synthesis and Applications
- Parvovirus B19 Infection Studies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuropeptides and Animal Physiology
- Thyroid Disorders and Treatments
- Cancer Treatment and Pharmacology
- Hematological disorders and diagnostics
- Animal Virus Infections Studies
- PI3K/AKT/mTOR signaling in cancer
- Long-Term Effects of COVID-19
- Chronic Lymphocytic Leukemia Research
- Growth Hormone and Insulin-like Growth Factors
- Bone and Joint Diseases
National Research Center for Hematology Russian Academy of Medical Sciences
2020-2024
Kazan Federal University
2020-2022
Ministry of Health of the Russian Federation
2020
City Clinical Hospital No 31
2019
Federal Almazov North-West Medical Research Centre
2018
Russian Academy of Sciences
2015
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play key role in adaptive antiviral immune response killing infected and facilitating selection of virus-specific antibodies. However, neither dynamics cross-reactivity SARS-CoV-2-specific T-cell nor diversity resulting memory well understood. In this study, we use longitudinal high-throughput receptor (TCR) sequencing to track changes repertoire following two mild cases COVID-19. both donors, identified CD4+ CD8+...
The ongoing COVID-19 pandemic calls for more effective diagnostic tools. T cell response assessment serves as an independent indicator of prior exposure while also contributing to a comprehensive characterization SARS-CoV-2 immunity. In this study, we systematically assessed the immunogenicity 118 epitopes with immune cells collected from multiple cohorts vaccinated, convalescent, healthy unexposed, and SARS-CoV-2-exposed donors. We identified 75 immunogenic epitopes, 24 which were...
Adenovirus vaccines, particularly the COVID-19 Ad5-nCoV adenovirus vaccine, have emerged as promising tools in fight against infectious diseases. In this study, we investigated structure of T cell response to Spike protein SARS-CoV-2 virus used adenoviral vaccine a phase 3 clinical trial (NCT04540419). 69 participants, collected peripheral blood samples at four time points after vaccination or placebo injection. Sequencing receptor repertoires from Spike-stimulated cultures day 14 17...
Summary Understanding the hallmarks of adaptive immune response to SARS-CoV-2 is critical for fighting COVID-19 pandemic. We assessed antibody and T-cell reactivity in convalescent patients healthy donors sampled both prior during The numbers SARS-CoV-2-specific T cells were increased examined COVID-19. Combined with absence symptoms humoral across that group, this finding suggests some individuals might be protected by cross-reactivity. In we observed public diverse epitopes, revealing...
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play key role in adaptive antiviral immune response killing infected and facilitating selection of virus-specific antibodies. However neither dynamics cross-reactivity SARS-CoV-2-specific cell nor diversity resulting memory are well understood. In this study we use longitudinal high-throughput receptor (TCR) sequencing to track changes repertoire following two mild cases COVID-19. both donors identified CD4+ CD8+...
Abstract T cells play a pivotal role in reducing disease severity during SARS-CoV-2 infection and formation of long-term immune memory. We studied 50 COVID-19 convalescent patients found that cell response was induced more frequently persisted longer than circulating antibodies. identified 756 clonotypes specific to nine CD8+ epitopes. Some epitopes were recognized by highly similar public clonotypes. Receptors for other extremely diverse, suggesting alternative modes recognition. tracked...
Understanding the hallmarks of adaptive immune response to SARS-CoV-2 is critical for fighting COVID-19 pandemic. We assessed antibody and T-cell reactivity in convalescent patients healthy donors sampled both prior during The numbers SARS-CoV-2-specific T cells were increased examined COVID-19. Combined with absence symptoms humoral across that group, this finding suggests some individuals might be protected by cross-reactivity. In we observed public diverse epitopes, revealing receptor...
In mid-2021, the SARS-CoV-2 Delta variant caused third wave of COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes efficiency neutralizing antibodies to spike protein. However, much less attention was paid T-cell response and presentation virus peptides by MHC-I molecules. this study, we compared features HLA-I genotype symptomatic patients with first waves pandemic. As a result, could identify diminishing carriers
Background. The most promising variant of adoptive immunotherapy the B-line oncohematological diseases includes use cells with chimeric antigen receptor (CAR T-cells), that showed extraordinary results in clinical studies. Aim. To manufacture CAR T-cells for and to study their cytotoxicity vitro. Methods. Human T-lymphocytes were transduced by lentiviral vector containing anti-CD19-CAR, RIAD, GFP genes. T-cell transduction efficacy was assessed on basis protein signal flow cytometry....
Abstract The ongoing COVID-19 pandemic calls for more effective diagnostic tools, and T cell response assessment can serve as an independent indicator of prior exposure while also contributing to a comprehensive characterization SARS-CoV-2 immunity. In this study, we systematically assessed the immunogenicity 118 epitopes with immune cells collected from multiple cohorts vaccinated, convalescent, healthy unexposed exposed donors. We identified seventy-five immunogenic epitopes, 24 which were...
Background . Secondary hemophagocytic lymphohystiocytosis (sHLH) is a hyperinflammatory reaction provoked by some trigger (cancer, autoimmune or infection). The majority of affected patients are at high risk fatal multiple organ failure without getting immunsupressive treatment. Objective Clinical and laboratory profile sHLH patients. Materials methods Retrospective study included clinical, instrumental lab data from the 91 followed between June 2009 2019. Diagnosis had been based on...
The secondary hemophagocytic syndrome is a life-threatening condition characterized by non-specifc manifestations: systemic inflammatory reaction, cytopenia, liver affection, high content of ferritin in blood serum. One manifestations decreasing level glycated serum expressed percentage total level. detection can be applied for differentiated diagnosis with cli9nically similar conditions, including septic process. purpose study was to determine clinical value easurement diagnostic and...