A5001526557- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Immune responses and vaccinations
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- COVID-19 epidemiological studies
- Rheumatoid Arthritis Research and Therapies
- Virus-based gene therapy research
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Advanced Biosensing Techniques and Applications
- Long-Term Effects of COVID-19
- Chronic Lymphocytic Leukemia Research
- Healthcare Systems and Public Health
- Galectins and Cancer Biology
National Research Center for Hematology Russian Academy of Medical Sciences
2016-2024
Miltenyi Biotec (Germany)
2023
National Medical Research Center of Cardiology
2021-2022
Ministry of Health of the Russian Federation
2016-2019
Lomonosov Moscow State University
2017-2019
Engelhardt Institute of Molecular Biology
2008-2017
N. I. Lobachevsky State University of Nizhny Novgorod
2016
Russian Academy of Sciences
2012
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play key role in adaptive antiviral immune response killing infected and facilitating selection of virus-specific antibodies. However, neither dynamics cross-reactivity SARS-CoV-2-specific T-cell nor diversity resulting memory well understood. In this study, we use longitudinal high-throughput receptor (TCR) sequencing to track changes repertoire following two mild cases COVID-19. both donors, identified CD4+ CD8+...
Overexpression of TNF contributes to pathogenesis multiple autoimmune diseases, accounting for a remarkable success anti-TNF therapy. is produced by variety cell types, and it can play either beneficial or deleterious role. In particular, in autoimmunity pathogenic may be derived from restricted cellular sources. this study we evaluated the feasibility cell-type-restricted inhibition vivo. To end, engineered MYSTI (Myeloid-Specific Inhibitor)--a recombinant bispecific antibody that binds...
To predict the spread of coronavirus disease (COVID-19), information regarding immunological memory for disease-specific antigens is necessary. The possibility reinfection, as well efficacy vaccines COVID-19 that are currently under development, will largely depend on quality and longevity in patients. elucidate process humoral immunity we analysed generation plasmablasts virus receptor-binding domain (RBD)-specific B (Bmem) cells patients during acute phase COVID-19.The frequencies...
T cells play a vital role in combatting SARS-CoV-2 and forming long-term memory responses. Whereas extensive structural information is available on neutralizing antibodies against SARS-CoV-2, such SARS-CoV-2-specific T-cell receptors (TCRs) bound to their peptide-MHC targets lacking. Here we determine the structures of public private TCR from COVID-19 convalescent patients complex with HLA-A2 two spike protein epitopes (YLQ RLQ). The reveal basis for selection particular TRAV TRBV germline...
During the ongoing coronavirus disease 2019 (COVID-19) pandemic, many individuals were infected with and have cleared virus, developing virus-specific antibodies effector/memory T cells. An important unanswered question is what levels of T-cell antibody responses are sufficient to protect from infection.
T cells play a crucial role in combatting SARS-CoV-2 and forming long-term memory responses to this coronavirus. The emergence of variants that can evade cell immunity has raised concerns about vaccine efficacy the risk reinfection. Some epitopes elicit clonally restricted CD8
The ongoing COVID-19 pandemic calls for more effective diagnostic tools. T cell response assessment serves as an independent indicator of prior exposure while also contributing to a comprehensive characterization SARS-CoV-2 immunity. In this study, we systematically assessed the immunogenicity 118 epitopes with immune cells collected from multiple cohorts vaccinated, convalescent, healthy unexposed, and SARS-CoV-2-exposed donors. We identified 75 immunogenic epitopes, 24 which were...
Since multiple different T-cell receptor (TCR) sequences can bind to the same peptide-MHC combination and number of TCR-sequences that theoretically be generated even exceeds T cells in a human body, likelihood many public identical (PUB-I) frequently contribute immune responses has been estimated low. Here, we quantitatively analyzed TCR-repertoires 190 purified virus-specific memory populations, directed against 21 epitopes Cytomegalovirus, Epstein-Barr virus Adenovirus isolated from 29...
The development of effective vaccines against SARS-CoV-2 remains a global health priority. Despite extensive use, the effects Sputnik V on B cell immunity need to be explored in detail. We performed comprehensive profiling humoral and responses cohort vaccinated subjects (n = 22), demonstrate that vaccination results robust immunity. show memory (MBC) antibody were heavily dependent whether vaccinee had history infection or not. 85 days after first dose vaccine, ex vivo stimulated MBCs from...
Adenovirus vaccines, particularly the COVID-19 Ad5-nCoV adenovirus vaccine, have emerged as promising tools in fight against infectious diseases. In this study, we investigated structure of T cell response to Spike protein SARS-CoV-2 virus used adenoviral vaccine a phase 3 clinical trial (NCT04540419). 69 participants, collected peripheral blood samples at four time points after vaccination or placebo injection. Sequencing receptor repertoires from Spike-stimulated cultures day 14 17...
Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective immunoregulatory functions, their systemic neutralization carries the potential unwanted side effects. Therefore, next-generation anti-cytokine therapies would seek to selectively neutralize cytokine signaling, leaving normal function intact. Fortunately, biology of provides several...
Summary Understanding the hallmarks of adaptive immune response to SARS-CoV-2 is critical for fighting COVID-19 pandemic. We assessed antibody and T-cell reactivity in convalescent patients healthy donors sampled both prior during The numbers SARS-CoV-2-specific T cells were increased examined COVID-19. Combined with absence symptoms humoral across that group, this finding suggests some individuals might be protected by cross-reactivity. In we observed public diverse epitopes, revealing...
Transplantation of allogeneic hematopoietic stem cells is the only curative option for a number diseases system. It intended to replace system recipient with donor’s. However, when mature T contained in graft enter organism, it may lead severe post-transplant complication, “graft versus host” disease (GVHD). occurs due fact that donor immune contains cell clones specific alloantigens. These are activated upon encountering their antigens, thus causing systemic damage healthy tissues....
Despite measures taken world-wide, the coronavirus disease 2019 (COVID-19) pandemic continues. Because efficient antiviral drugs are not yet widely available, vaccination is best option to control infection rate. Although this obvious in case of COVID-19-naive individuals, it still unclear when individuals who have recovered from a previous SARS-CoV-2 should be vaccinated and whether raises immune responses against its novel variants. In study, we collected peripheral blood 84 healthy human...
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play key role in adaptive antiviral immune response killing infected and facilitating selection of virus-specific antibodies. However neither dynamics cross-reactivity SARS-CoV-2-specific cell nor diversity resulting memory are well understood. In this study we use longitudinal high-throughput receptor (TCR) sequencing to track changes repertoire following two mild cases COVID-19. both donors identified CD4+ CD8+...
Abstract T cells play a pivotal role in reducing disease severity during SARS-CoV-2 infection and formation of long-term immune memory. We studied 50 COVID-19 convalescent patients found that cell response was induced more frequently persisted longer than circulating antibodies. identified 756 clonotypes specific to nine CD8+ epitopes. Some epitopes were recognized by highly similar public clonotypes. Receptors for other extremely diverse, suggesting alternative modes recognition. tracked...
Background To determine the immunogenicity, efficacy, reactogenicity, and safety of a single dose recombinant adenovirus type-5 vectored COVID-19 vaccine (Ad5-nCoV, 5 × 10 viral particles per 0.5 mL dose), we conducted single-dose, randomised, double-blind, placebo-controlled, parallel group (3:1 Ad5-nCoV:placebo), phase 3 trial (Prometheus). Methods From 11-September-2020 to 05-May-2021, across six sites in Russian Federation, 496 participants were injected with either placebo or Ad5-nCoV...