A5046468919- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- vaccines and immunoinformatics approaches
- Xenotransplantation and immune response
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
- RNA and protein synthesis mechanisms
- Abdominal vascular conditions and treatments
- RNA Interference and Gene Delivery
- Liver Disease and Transplantation
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
- T-cell and Retrovirus Studies
- Immune cells in cancer
- Immune Cell Function and Interaction
- Biomarkers in Disease Mechanisms
- Enzyme Structure and Function
- Renal Transplantation Outcomes and Treatments
- Organ and Tissue Transplantation Research
Odessa National Medical University
2018-2023
National Research Center for Hematology Russian Academy of Medical Sciences
2017-2020
University of Wyoming
2017
Lomonosov Moscow State University
2017
Ministry of Health of the Russian Federation
2017
Transplantation of allogeneic hematopoietic stem cells is the only curative option for a number diseases system. It intended to replace system recipient with donor’s. However, when mature T contained in graft enter organism, it may lead severe post-transplant complication, “graft versus host” disease (GVHD). occurs due fact that donor immune contains cell clones specific alloantigens. These are activated upon encountering their antigens, thus causing systemic damage healthy tissues....
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is routinely used to treat malignancies. The eradication of residual tumor cells during engraftment mediated by donor cytotoxic T lymphocytes reactive alloantigens. In the context HLA-matched alloantigens are encoded various polymorphic genes situated outside HLA locus, so-called minor histocompatibility antigens (MiHAs). Recently MiHAs have been recognized as promising targets for posttransplant T-cell immunotherapy, they...
Improvements in the description of amino acid substitution are required to develop better pseudo-energy-based protein structure-aware models for use phylogenetic studies. These used characterize probabilities and enable simulation sequences over a phylogeny. A characterization turn enables numerous downstream applications, like detecting positive selection, ancestral sequence reconstruction, evolutionarily-motivated engineering. Many existing Markov molecular evolution disregard structure...
The hyperplastic processes of the endometrium can arise not only against background excessive influence estrogen, but also epigenetic damages that affect apoptosis, cell proliferation, differentiation, and adhesion, DNA reparation. aim our study was to investigate analyze status methylation promoter SFRP2 gene in patients with endometrium.The groups were following: I - endometrial hyperplasia (EH, n = 9); II intraepithelial neoplasia (EIN, 10), III control groups: 1) cancer (EC, 4), 2)...
The wide range of techniques could be employed to find mismatches in minor histocompatibility antigens between transplant recipients and their donors. In the current study we compared three genotyping methods based on polymerase chain reaction (PCR) for four antigens. Three tested methods: allele-specific PCR, restriction fragment length polymorphism real-time PCR with TaqMan probes demonstrated 100% reliability when Sanger sequencing all studied polymorphisms. High resolution melting...
Hematopoietic stem cells transplantation of (HSCT) from the related or unrelated donor is used as a treatment for hematopoietic system malignancies. However, triggers an immune response to recipient’s antigens. The healthy tissues called graft versus host reaction (GVHD), and tissue in context malignant disease leukemia (GVL) eff ect. development GVL reactivity favorable consequence transplantation, since it eliminates residual tumor prevents relapse. It was demonstrated that arises towards...
The aim of study.An increase in the concentration matrix metalloproteinase type 9 (MMP-9) and tissue inhibitor 1 (TIMP-1) blood serum during pregnancy women with a burdened premorbid background indicates their role at beginning placentation process.A significant proteolysis enzyme decrease TIMP-1 threat miscarriage was established, which can be considered sign impaired homeostasis extracellular matrix.Materials methods.In pregravid period patients liver function (non-alcohol steatohepatitis...
Annotation. Goal – to identify and assess the most significant risk factors for development of simple non-atypical endometrial hyperplasia (SNAEH) complex (CNAEH) in women. Retrospective analysis anamnestic data 58 case histories patients with SNAEH, 35 CNAEH 30 women control group, which allowed hyperproliferative processes endometrium (HPE) research, statistical significance was further assessed by calculating odds ratio (OR). The main feature associated SNAEH is heredity OR = 49.73 (95%...