The hyperplastic processes of the endometrium can arise not only against background excessive influence estrogen, but also epigenetic damages that affect apoptosis, cell proliferation, differentiation, and adhesion, DNA reparation. aim our study was to investigate analyze status methylation promoter SFRP2 gene in patients with endometrium.The groups were following: I - endometrial hyperplasia (EH, n = 9); II intraepithelial neoplasia (EIN, 10), III control groups: 1) cancer (EC, 4), 2)...

Background. COVID-19 pandemic is accompanied by a considerable number of morbidity cases among pregnant women. Certain knowledge has been accumulated about the histopathological features placenta during SARS-CoV-2 infection. Specific proteomic studies function are insufficient.Objective study: to study perinatal outcomes pregnancy and expression epidermal growth factor receptors (EFGR) prohibitin (PHB) in women with infection comparison data group healthy without history.Materials methods....

Objective of the study: to investigate possibility predicting early neonatal adaptation newborns based on clinical and instrumental data that assesses status pregnant woman with COVID-19 infection fetus.Materials methods. The participants study were 58 women a diagnosis (group A) 40 physiological course pregnancy B), as well their newborns. In addition analysis standard examinations results, perinatal consequences for mother fetus/newborn, association between saturation level (SрO2) in...

Introduction. The hormonal system “vitamin D/vitamin D receptors” (VD/VDR) is involved in the regulation of numerous physiological processes. VD lack or deficiency associated with a number different diseases, including pregnancy complications.Purpose study: to determine status and its effect on course gestational process women from southern region Ukraine.Materials methods. 459 were examined, 318 (69.3%) them main group 141 (30.7%) comparison group.In addition standard general clinical...

In recent years, there has been an increase in the number of operations on uterus women reproductive age with formation "uterine scarring syndrome" (USS), which can lead to complicated pregnancy and childbirth. To assess anatomical functional features uterine scar, perinatal outcomes USS women. A prospective analysis clinical anamnestic data, childbirth 398 was conducted; ultrasound Doppler assessment morpho-functional status using Accuvix V20 Prestige (Samsung Medison, Republic Korea) made....

In this contemporary studies literature review, the preeclampsia etiopathogenesis has been analyzed on pathogenetic mechanisms basis, etiology of which is associated with variable degrees increase in intra-abdominal pressure during pregnancy. The development mechanistic concept structure based reninangiotensin-aldosterone system and immunological factors violation occurred along intraabdominal hypertension considered. Attention paid to reference values identification pregnancy different...

Preeclampsia (PE) of pregnant women remains one the most important current problems modern obstetrics. Despite various theories about pathogenetic mechanisms its development, new directions in studying this problem are continued to emerge. One promising areas researches works that devoted vitamin D (VD) role genesis PE, which were appeared due discovery "non-classical" and "extra-skeletal" effects calcitriol. It is known now regulatory system, characterized by receptors (VDR), functioning at...

The high prevalence of the vitamin D (VD) deficiency states (VDDS) among adults, as well data on pleiotropic effects calcitriol suggests its participation in development various complications and pregnancy outcomes. objective present study is to analyze course delivery tactics pregnant women with placental dysfunction (PD) depending availability. We examined 56 patients PD (I – main group) 40 conditionally healthy physiological (II control group). In addition standard clinical laboratory...

Purpose. Delivery by caesarean section (CS) is now becoming an “epidemic” — in some countries it reaches 50% or more; often the operation carried out at request slightest doubt of woman. An increase CS frequency not always accompanied a predicted improvement perinatal mortality. Objective: To develop strategy for women to gain positive pregnancy experience based on analysis database linear maternity hospital using Robson classification. Materials and methods. Retrospective childbirth...

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)

Background. The problem of vitamin D (VD) deficiency in the population, general, and pregnant women, particular, related diseases, including musculoskeletal system, remains one most widespread medical social problems our time. purpose was to determine frequency diseases females at high infection risk (HIR) with impaired status single-nucleotide Bsml polymorphism its receptor gene. Materials methods. Fifty-six women (main group) HIR 40 healthy (control had been examined. level...

Research objectives: the study examined effect of BsmI polymorphism gene encoding vitamin D receptors (A > G, rs1544410) on human placental dysfunction. Materials and methods. An observational-analytical carried out according to «case-control» principle. The was conducted in two maternity hospitals city Odessa, Ukraine over same period time. Special enzyme immunoassay molecular genetic studies were at LLC «Diagnostic Center Evgenika» Odessa. intervention group included a total 56 pregnant...

To compare structural condition of the bone tissue in women with verified perinatal infection (vPI) and healthy pregnant dynamics gestation. a prospective study gestation has been performed 363 women, 235 them (group I – main group) vPI. decrease mineral density (BMd) have identified already 2nd trimester. 128 formed control group II). ultrasound densitometry was used for assessment state tissue. BMd indexes matched normal only 18.29 % (subgroup IB) vPI trimester pregnancy. osteopenia...