A5019098289- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Pregnancy-related medical research
- Hypothalamic control of reproductive hormones
- Nicotinic Acetylcholine Receptors Study
- Biochemical effects in animals
- Thyroid Disorders and Treatments
- Estrogen and related hormone effects
- Chemical Synthesis and Analysis
- Growth Hormone and Insulin-like Growth Factors
- Click Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Pancreatic function and diabetes
- Supramolecular Self-Assembly in Materials
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Protein Hydrolysis and Bioactive Peptides
- Advanced Fluorescence Microscopy Techniques
- Neurobiology and Insect Physiology Research
- Calcium signaling and nucleotide metabolism
- Pharmacological Effects and Assays
- Lipid Membrane Structure and Behavior
- melanin and skin pigmentation
Institute of Evolutionary Physiology and Biochemistry
2004-2025
Institute of Organic Synthesis
2021
BIOCAD (Russia)
2021
St Petersburg University
2015-2018
Russian Academy of Sciences
2008-2015
Institute of Macromolecular Compounds
2012-2015
Background: Antithyroid drugs used to treat autoimmune hyperthyroidism lead thyroid hormone deficiency when for a long time. In this regard, it is relevant develop thyroid-stimulating receptor (TSHR) regulators capable of inhibiting TSHR activation by agonists acting on the orthosteric site (TSH, autoantibodies TSHR) and stimulating its basal activity. This function can be performed allosteric with agonist activity negative modulators (ago-NAM).Aim: A comparative study effects TPY4,...
Organelle targeting is an important area of research for studying organelle function and morphology, signaling, organelle-targeted drug delivery. Here, we report the development dual cycloalkyne reagents that can undergo click reactions with azides directly in choice (mitochondria endoplasmic reticulum (ER))—Mito-ER systems. The design Mito-ER systems based on benzothiophene-fused azacyclononyne BT9N, featuring a mito-targeting (thiophene) mitochondria-maintaining (thiourea) functional...
Organelle targeting is an important area of research for studying organelle function and morphology, signaling, organelle-targeted drug delivery. Here, we report the development dual cycloalkyne reagents that can undergo click reactions with azides directly in choice (mitochondria endoplasmic reticulum (ER))—Mito-ER systems. The design Mito-ER systems based on benzothiophene-fused azacyclononyne BT9N, featuring a mito-targeting (thiophene) mitochondria-maintaining (thiourea) functional...