A5079184749- Thermoregulation and physiological responses
- COVID-19 Clinical Research Studies
- Heart Rate Variability and Autonomic Control
- SARS-CoV-2 and COVID-19 Research
- Infrared Thermography in Medicine
- Cardiovascular Health and Disease Prevention
- Healthcare Systems and Public Health
- Long-Term Effects of COVID-19
- Non-Invasive Vital Sign Monitoring
- Vaccine Coverage and Hesitancy
- COVID-19 and healthcare impacts
- Acute Myocardial Infarction Research
- Parkinson's Disease Mechanisms and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Autophagy in Disease and Therapy
- Human Health and Disease
- Climate Change and Health Impacts
- Cardiovascular Disease and Adiposity
- Inflammasome and immune disorders
- Intramuscular injections and effects
- Influenza Virus Research Studies
- Diabetes and associated disorders
- Boron Compounds in Chemistry
- COVID-19 and Mental Health
- Blood properties and coagulation
National Research Center for Preventive Medicine
2016-2025
Ministry of Health of the Russian Federation
2018-2023
Institute of Semiconductor Physics
2023
National Medical Research Center of Dentistry and Maxillofacial Surgery
2016
Moscow State University of Fine Chemical Technologies
2003-2007
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Создание руководства поддержано Советом по терапевтическим наукам отделения клинической медицины Российской академии наук.
The present work is focused on the study of changes in microcirculation parameters patients who have undergone COVID-19 by means wearable laser Doppler flowmetry (LDF) devices. microcirculatory system known to play a key role pathogenesis COVID-19, and its disorders manifest themselves long after patient has recovered. In work, were studied dynamics one for 10 days before his disease 26 recovery, data from group undergoing rehabilitation compared with control group. A consisting several...
The present study evaluated the relationships of serum levels cyclic dinucleotide 2'3'-cyclic GMP-AMP (cGAMP) marker activation pattern-recognition receptors with immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status and endothelial dysfunction. Selected groups from two cohorts (cohort 1 307 healthy volunteers cohort 2 218 coronary heart disease [CHD] patients). COVID-19 infection was confirmed by detection IgG-SARS SARS-CoV-2 S1...
Biological age has attracted increased attention of the medical community in recent years. It is individual for each person and currently there no clear classification dividing into groups that could help determine whether rate aging a particular normal or pathological. Today, scientists are conducting large number clinical laboratory studies to find optimal marker biological would meet all requirements. The review aim analyze summarize available data on mechanisms aging, development novel...
Until now, there remains a certain interest in studying the role of booster vaccination formation post-vaccination immunity against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The variety vaccine platforms provides opportunity to choose them for population and healthcare workers, also allows taking into account individual characteristics each patient. Aim. To estimate incidence disease 2019 (COVID-19) as result using one type heterologous vaccines during primary repeated...
Abstract Objective PBR characterizes penetration of red blood cells inside glycocalyx and its thickness can have profound impact on microcirculation other vascular parameters. The goal our study was to reliably quantify assess potential use as a new marker cardiovascular pathology. Methods included 208 patients (123 men 85 women from 40 65 years age) with various grades SCORE risk index IHD. quantified by sidestream dark field capillaroscopy green light excitation. Cutaneous evaluated laser...
This work aims to study the functional state of resistive skin microvessels in patients with newly diagnosed arterial hypertension (AH), using portable laser Doppler flowmetry (LDF) devices. The included 89 men aged 30 60 years (44.4 ± 8.5) who had no known medical complaints, subjectively considered themselves healthy, and did not take medications on a regular basis. All underwent LDF left forearm, daily blood pressure (BP) monitoring (DBPM) arm, echocardiography, laboratory tests....
Hypertension remains a pandemic of the 21st century, being major factor premature death. The introduction imaging methods into clinical practice revealed high prevalence target organ damage mediated by hypertension. One systemic organs in hypertension is endothelium. Its plays an important role initiation cardiovascular disease continuum. On other hand, structure and function defects endothelium considered as possible reason for increase blood pressure. This literature review systematizes...
The manifestations, severity, and mortality of COVID-19 are considered to be associated with the changes in various hematological parameters immunity. Associations immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status cardiac function biochemical apparently health subjects poorly understood.The present cross-sectional study included 307 healthy volunteers (24-69 years age; 44.8 ± 8.6 years; 80.4% men) was initiated 2019 before...
With the ongoing SARS-CoV-2 pandemic, safety and efficacy of vaccine prophylaxis with new vaccines have become vital. Objective. To study tolerability Gam-COVID-Vac (Sputnik V) in short term a real-world setting example Federal remote consulting center on vaccination against coronavirus infection COVID-19 National Medical Research Center for Therapy Preventive Medicine. Materials methods. We retrospectively analyzed data from registration cards first 500 voluntary recipients who received two...
In the context of ongoing coronavirus disease 2019 (COVID-19) pandemic, it is extremely important to study immunogenicity and immune response duration in different vaccines. Aim . As part a prospective observational study, levels anti-SARS-CoV-2 S-protein IgG antibodies individuals vaccinated with Gam-COVID-Vac CoviVac Material methods The data 93 people who completed first 3 visits were analyzed, 23 whom vaccine 70 — vaccine. We collected blood before injection doses I II, as well 42 days...
Acute coronary syndrome (ACS) is caused by an acute mismatch between myocardial oxygen demand and its supply. This mechanism largely associated with the progression of atherosclerosis in combination inflammatory response, hypoxemia, blood procoagulation. Patients coronavirus disease 2019 (COVID-19), aggravated cardiovascular diseases comorbidities, are at high risk ACS. Aim . To analyze publications, which reflects development ACS patients COVID-19, pathogenesis, clinical course. Material...
This study aims to investigate the strength of synchronization between autonomic control loops cardiovascular system (CVS) in patients with COronaVIrus Disease 2019 (COVID-19). Methods — We calculated total percent phase index (S index) heart rate and vascular tone two sample groups: healthy individuals COVID-19 patients. Results The group-average value S is lower comparing individuals, Mann-Whitney U-test confirmed that differences are statistically significant. Conclusion Obtained results...
Aim. To study the functional state of terminal arteries and arterioles skin using photoplethysmography (PPG) in men with hypertension (HTN) low moderate cardiovascular risk (CVR) to identify morphofunctional diagnostic criteria associated HTN. Material methods. A total 118 healthy (30-60 years old) underwent clinical biochemical blood tests, PPG, ultrasound cardiac main arteries, 24-hour pressure monitoring. According monitoring, two groups were formed: control group — 59 normotensive men,...
Objective. To study the dynamics of microcirculatory blood flow in skin during a course use electrical stimulator AVR-051 men low and moderate cardiovascular risk with newly diagnosed arterial hypertension. Materials methods. The single-center placebo-controlled included 44 working age (30–60 years) hypertension, who were randomly divided into 2 groups. control group (CG) 30 underwent stimulation commercial device. placebo (PG) 14 used device, electrostimulation function disabled. design 3...
Aim. To study sex characteristics of cutaneous microvascular structure and function in a cohort healthy working-age people without cardiovascular diseases. Material methods . The included 35 men (42±4 years) 34 women (41 ±5 years). system was assessed all patients. microcirculatory bed the skin investigated by following non-invasive methods: 1) computerized video capillaroscopy; 2) laser Doppler flowmetry; 3) photoplethysmography. Results. According to capillaroscopy men, compared with...
The review describes the skin microcirculation disorders with essential arterial hypertension by capillaroscopy and laser Doppler flowmetry. methods are complementary to each other provide information about structural functional state of arteriolar, capillary venular vessels in microvasculature. most common microvasculature attending vasomotor dysfunction microvascular endothelium, a decreasing dilator reserve, rarefaction. bulk was obtained non-acral areas skin, where tissue perfusion is...
<h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Изучить структурно-функциональное состояние микрососудистого русла кожи в области пальца и предплечья с определением нормативных диапазонов выявить наличие взаимосвязей между параметрами микроциркуляции показателями центральной гемодинамики у здоровых мужчин трудоспособного возраста. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> В исследование были включены 60 возрасте от 30 до лет (средний возраст 43±7,9 года), которые, по данным инструментально-лабораторных методов исследования, не...
<h3></h3> В условиях продолжающейся пандемии COVID-19 при значительном разнообразии имеющихся вакцин крайне актуально изучение их влияния на систему гемостаза. <h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> рамках проспективного наблюдательного исследования изучить особенности тромбодинамики у лиц, вакцинированных против SARS-CoV-2 вакцинами Гам-КОВИД-Вак и КовиВак. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> Проанализированы данные 99 вакцинированных, которые завершили первые 3 визита: из них 18 были привиты вакциной...
Highlights. Nowadays the only way to prevent a new coronavirus infection is vaccination. Overcoming such problems as gradual decrease in effectiveness of post-vaccination immunity and emergence strains SARS-CoV-2 possible due booster The review highlights current data on immunogenicity various vaccination regimens prospects for studying this issue Russian Federation. Abstract. COVID-19 pandemic going on, which makes it crucial spread disease. Vaccination specific prevention COVID-19. virus...
<h3></h3> Выявление отягощенной наследственности, жалоб и симптомов, обусловленных рядом социально значимых неинфекционных заболеваний, является важной задачей, которая должна быть решена при проведении обязательных профилактических медицинских осмотров, а также диспансеризации. В России разработана анкета для профилактического медицинского осмотра диспансеризации, но отсутствует осмотров. Кроме того, до сих пор не разработаны унифицированы инструменты анкеты, предназначенные оценки тревоги...
Aim. To provide data on the diagnostic and prognostic value of questionnaire survey for post-COVID-19 syndrome during screening regular medical check-ups employees, as well preventive examinations. Material methods . This single-center cross-sectional comparative study involved 1120 people (92,1% general population — all employees organization), including 195 men (67,3% population) 925 women (79,5% population). All participants filled out (PS) detection questionnaire, Hospital Anxiety...