A5045100975- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Molecular Biology Techniques and Applications
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- Breast Implant and Reconstruction
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- Advanced Biosensing Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Eosinophilic Disorders and Syndromes
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
Japanese Foundation For Cancer Research
2014-2024
The Cancer Institute Hospital
2012-2024
Terry Fox Research Institute
2020
University of Amsterdam
2018-2019
Institute for Molecular Science
2018-2019
ShanghaiTech University
2019
Nanjing University of Science and Technology
2019
Universidad de Murcia
2019
Sichuan University
2019
University of Würzburg
2018
Abstract G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting for cancer treatment is a very promising prospect. Here, we show that CX-5461 stabilizer, with specific toxicity against BRCA deficiencies cells polyclonal patient-derived xenograft models, including tumours resistant PARP inhibition. Exposure CX-5461, its related drug CX-3543, blocks replication forks induces ssDNA gaps or breaks. The NHEJ pathways...
In breast cancer, the TP53 gene is frequently mutated and mutations have been associated with poor prognosis. The prognostic impact of different types across molecular subtypes still poorly understood. Here, we characterize spectrum significance respect to PAM50 integrative clusters (IC).
Abstract BACKGROUND: Conventional histopathological examination is limited in measuring accurate total metastatic volume a lymph node. Recently, molecular‐based procedure to detect node metastases, one‐step nucleic acid amplification (OSNA) assay, has been developed. OSNA assay can assess whole and yields semiquantitative results. The authors compared the performance intraoperative detection of sentinel metastases with using versus routine frozen section (FS) histology 2 mm‐sectioned...
In breast cancer patients, tumor heterogeneity is associated with prognosis and therapeutic response; however, the epigenetic diversity that exists in primary tumors remains unknown. Using a single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq), we obtained accessibility profiles of 12,452 cells from 16 patients including 11 luminal, 1 luminal-HER2, HER2+, 3 triple-negative subtypes. Via this profiling process, were classified into microenvironment, highlighting...
Abstract Background The intratumor heterogeneity (ITH) of cancer cells plays an important role in breast resistance and recurrence. To develop better therapeutic strategies, it is necessary to understand the molecular mechanisms underlying ITH their functional significance. Patient-derived organoids (PDOs) have recently been utilized research. They can also be used study as cell diversity thought maintained within organoid line. However, no reports investigated transcriptomic derived from...
The agonistic/antagonistic biocharacter of selective estrogen receptor modulators (SERMs) can have therapeutic advantages, particularly in the case premenopausal breast cancers. Although contradictory effects these been studied terms crosstalk between α (ER) and coactivator dynamics growth factor signaling, molecular basis mechanisms is still obscure. We identify a series regulatory controlling cofactor on ER SERM function, whose activities require F-box protein 22 (Fbxo22). Skp1, Cullin1,...
Sentinel lymph node biopsy (SNB) is the standard treatment of node-negative breast cancer; however, whether SNB should be performed for patients with node-positive disease before neoadjuvant chemotherapy (NAC) controversial. We evaluated accuracy after NAC in cancer nodal metastasis to determine false-negative rate (FNR) and detection SNB.In present multicenter prospective study from September 2011 April 2013, 143 positive axillary nodes, proved by fine needle aspiration cytology at initial...
Secretory carcinoma (SC) is a rare histological type of breast cancer, and ETV6-NTRK3 gene fusion highly specific to it. The differential diagnoses SC include acinic cell (ACCA) cystic hypersecretory (CHC), as well invasive ductal (IDC). For patients with these but distinctive subtypes, its histopathological mimics should be differentiated from each other. However, markers have not yet been assessed systematically, we aimed identify evaluate novel existing markers.We reviewed 19 cases...
Abstract Background Oestrogen receptor (ER) signalling-dependent cancer cell growth is one of the major features ER-positive breast (BC). Inhibition ER function a standard and effective treatment for tumours; however, ~20% patients with BC experience early or late recurrence. In this study, we examined intertumour heterogeneity from an epigenetic perspective based on hypothesis that intrinsic difference in states around signalling pathway underlies endocrine therapy resistance. Methods We...
Cellular senescence and senescence-associated secretory phenotype (SASP) in stromal cells within the tumor microenvironment promote cancer progression. Although cellular has been shown to induce changes higher-order chromatin structure abnormal transcription of repetitive elements genome, functional significance these is unclear. In this study, we examined human satellite II (hSATII) loci pericentromere understand their significance. Our results indicated that hSATII decompact during...
Invasive micropapillary carcinoma (IMP) of the breast is a rare variant invasive and most cases IMP are associated with nodal metastasis lymphatic invasion. Lesions composed an component alone almost always coexist other pathological components. However, few reports have documented along its proportion coexistent type. We analyzed total 486 cancer lesions operated in our hospital 1998. classified into five groups by each lesion. Then we evaluated incidence invasion group. The containing any...
For breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ ( DCIS ), sentinel lymph node SN ) biopsy has been proposed as an axillary staging procedure selected higher likelihood having occult invasive lesions. With detailed histological examination primary tumors and molecular whole‐node analysis s, we aimed to validate whether this selective application accurately identifies metastasis. The subjects were 336 needle‐biopsy who underwent using the one‐step nucleic...
To evaluate acute morbidity, radiation dermatitis and pneumonitis, of Japanese patients treated with whole breast hypofractionated radiotherapy (RT) after breast-conserving surgery (BCS), compared to conventional RT.Japanese who received RT BCS between October 2003 September 2006 were retrospectively reviewed. Patients had selected the or schedule irradiation 50 Gy in 25 fractions plus boost 40 16 boost. Radiation symptomatic pneumonitis graded according Common Terminology Criteria for...
The one-step nucleic acid amplification (OSNA) assay is a molecular-based lymph-node metastasis detection procedure that can assess whole node and yields semi-quantitative results for the of clinically relevant nodal metastases. We aimed to determine performance OSNA as an accurate staging tool in comparison with routine histological examination. Subjects comprised 183 consecutive patients pT1-2 breast cancer who underwent axillary dissection after positive sentinel-node (SN) biopsy assay....
The pathogenesis of lymph node metastases in preinvasive breast cancer – ductal carcinoma situ (DCIS) remains controversial. one-step nucleic acid amplification (OSNA) assay is a novel molecular method that can assess whole and detect clinically relevant metastases. In this retrospective cohort study, we determined the performance OSNA DCIS node-positive DCIS. subjects consisted 623 patients with who underwent sentinel (SN) biopsy. Of these, 2-mm-sectioned nodes were examined using...
The recurrence risk of estrogen receptor (ER)-positive breast cancer remains high for a long period time, unlike other types cancer. Late reflects the ability cells to remain dormant through various events, including stemness acquisition, but detailed mechanism is unknown. ESR1 locus enhancing and activating noncoding RNAs (ELEANORS) are cluster nuclear originally identified in recurrent cell model. Although their functions as chromatin regulators vitro well characterized, roles vivo...