A5071405218- Nanoparticle-Based Drug Delivery
- Chromatin Remodeling and Cancer
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Histone Deacetylase Inhibitors Research
- Cancer Treatment and Pharmacology
- Lipid Membrane Structure and Behavior
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Radiation Therapy and Dosimetry
- Advanced biosensing and bioanalysis techniques
- Neuroendocrine Tumor Research Advances
- Nanoplatforms for cancer theranostics
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- DNA and Nucleic Acid Chemistry
- Private Equity and Venture Capital
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Synthesis and biological activity
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
BC Cancer Agency
2012-2024
Celator Pharmaceuticals (Canada)
2008-2023
University of British Columbia
2002-2017
Molecular Oncology (United States)
2017
Universidade do Porto
2015
Instituto Politécnico Nacional
2012
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2012
Centro de Investigación en Materiales Avanzados
2012
St. Paul's Hospital
2002
Inimex Pharmaceuticals (Canada)
1999
Abstract G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting for cancer treatment is a very promising prospect. Here, we show that CX-5461 stabilizer, with specific toxicity against BRCA deficiencies cells polyclonal patient-derived xenograft models, including tumours resistant PARP inhibition. Exposure CX-5461, its related drug CX-3543, blocks replication forks induces ssDNA gaps or breaks. The NHEJ pathways...
Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a rare but aggressive and untreatable malignancy affecting young women. We others recently discovered that SMARCA4, gene encoding ATPase SWI/SNF chromatin-remodelling complex, only recurrently mutated in majority SCCOHT. The low somatic complexity SCCOHT genomes prominent role complex transcriptional control genes suggest cells may rely on epigenetic rewiring for oncogenic transformation. Herein, we report approximately 80%...
Abstract Irinotecan and cisplatin are two established anticancer drugs, which together constitute an effective combination for treating small-cell lung cancer. We investigated whether the efficacy of this could be improved by controlling drug ratios following in vivo administration. combinations were evaluated systematically ratio–dependent synergy vitro using a panel 20 tumor cell lines. In screening informatics on cytotoxicity identified consistently antagonistic region between...
Abstract Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but extremely lethal malignancy that mainly impacts young women. SCCOHT characterized by diploid genome with loss SMARCA4 and lack SMARCA2 expression, two mutually exclusive ATPases SWI/SNF chromatin-remodeling complex. We others have identified histone methyltransferase EZH2 as promising therapeutic target for SCCOHT, suggesting cells depend on alternation epigenetic pathways survival. In this study, we found...
Background Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle progression and tumorigenesis. Astemizole, a new promising antineoplastic drug, targets Eag1 by blocking ion currents. Herein, we characterized interaction between calcitriol astemizole as well their conjoint action in SUM-229PE, T-47D primary tumor-derived breast cancer cells. Methodology/Principal Findings Molecular...
This research underscores the potential of combining nanotechnology with conventional therapies in cancer treatment, particularly for challenging cases like pancreatic cancer. We aimed to enhance treatment by investigating synergistic effects gold nanoparticles (GNPs) and docetaxel (DTX) as radiosensitizers radiotherapy (RT) both vitro vivo, utilizing a MIA PaCa-2 monoculture spheroid model NRG mice subcutaneously implanted cells, respectively. Spheroids were treated GNPs (7.5 μg/mL), DTX...
Abstract Recent clinical trials show docetaxel (DTX), given in conjunction with radiation therapy (RT) and androgen suppression, improves survival high-risk prostate cancer. Addition of gold nanoparticles (GNPs) to this current DTX/RT protocol is expected further improve therapeutic benefits remarkably. However, the foundation for triple combination RT, DTX, GNPs must be elucidated ensure quicker facilitation clinic. In study, we explored use low concentrations DTX combined two cancer cell...
Clioquinol (CQ) is an FDA-approved topical antifungal agent known to kill cancer cells. This facilitated the initiation of clinical trials in patients with refractory hematologic malignancies. These repurposing efforts were not successful; this was likely due low intracellular levels drug owing poor absorption and rapid metabolism upon oral administration. CQ forms a sparingly soluble copper complex (Cu(CQ)
Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson's disease, whereas our previous analyses of public patient data revealed that decreased expression is associated with lung adenocarcinoma (LUAD). The clinical functional relevance repression in LUAD unknown. Here, we investigated associations clinicopathological variables asked whether knockout promotes murine tumorigenesis. In patients, reduced was significantly ongoing...
The first liposomal formulation of cisplatin to be evaluated clinically was SPI-077. Although the demonstrated enhanced tumor accumulation in preclinical models it did not enhance clinical efficacy, possibly due limited release from localized within tumor. We have examined a series formulations address vivo relationship between rate and efficacy P388 murine leukemia model. base phosphatidylcholine: phosphatidylglycerol: cholesterol altered C18 C16 phospholipid content influence membrane...
Purpose To investigate the use of liposomal irinotecan (Irinophore C™) plus or minus 5-fluorouracil (5-FU) for treatment colorectal cancer. Experimental Design The effect (IRI) and/or 5-FU exposure times on cytotoxicity was assessed in vitro against HT-29 LS174T human colon carcinoma cells. pharmacokinetics and biodistribution Irinophore C™ (IrC™) 5-FU, administered alone combination, were compared vivo. A subcutaneous model cancer Rag2-M mice utilized to assess efficacy IrC™ alone,...
Current chemoradiation therapy suffers from normal tissue toxicity. Thus, we are proposing incorporating gold nanoparticles (GNPs) and docetaxel (DTX), as they have shown very promising synergetic radiosensitization effects. Here, explored the effect of a DTX prodrug encapsulated in lipid (LNPDTX-P) on GNP uptake pancreatic cancer models vitro vivo. For experiment, cell line, MIA PaCa-2, was cultured dosed with 1 nM GNPs 45 free or an equivalent dose LNPDTX-P. vivo PaCa-2 cells were...