Although active oxygen species play important roles in the pathogenesis of various diseases, molecular mechanism for toxicity vascular diseases remains to be elucidated. Since endothelium-derived relaxing factor (EDRF) is inactivated by superoxide radicals vitro, oxidative stress and around endothelial cells may affect circulatory status animals. To study role related enzymes, such as dismutase (SOD), we have developed a fusion protein (HB-SOD) consisting human Cu/Zn-type SOD C-terminal...

A method to prepare cisplatin suspended in an oily lymphographic agent, Lipiodol (LPS), has been established deliver hepatocellular carcinoma (HCC) by the hepatic artery. Seventy-one patients, one Stage I, 16 II, III, and 38 IV, were treated with LPS therapy. partial response was obtained 33 cases (46.5%), a minor 20 (28.2%), no change 18 (25.3%). In 34 patients whose serum alpha-fetoprotein (AFP) levels greater than 400 ng/ml, AFP decreased 31 (91.2%). The more 50% 25 (73.5%) 75% 19...

The objective of this study is to describe a technique for preserving the autonomic nerve systematically, including hypogastric nerves, pelvic splanchnic and plexus its vesical branches, based on anatomic considerations nerves innervating urinary bladder, in radical hysterectomies assess postsurgical bladder function. A nerve-sparing hysterectomy was carried out 27 consecutive patients with uterine cervical cancer treated between 2000 2002. FIGO stages disease consisted 10 stage Ib1, 6 Ib2,...

Twenty-two patients with spontaneously occurring primary hypothyroidism were studied to evaluate the spontaneous reversibility of hypothyroid state. Twelve (54.5%) became euthyroid after restriction iodine intake for 3 weeks (reversible type). In remaining 10 patients, thyroid function did not improve alone, and thus, replacement therapy was required, (irreversible reversible type, 1) radioactive uptake 1 week restricted higher than in irreversible type [50.0 +/- 12.2% (+/- SD) vs. 4.3 3.2%;...

Des-gamma-carboxy prothrombin [DCP], a protein induced by vitamin K absence or antagonist-II and also abbreviated PIVKA-II, was evaluated as serologic marker for hepatocellular carcinoma (HCC). Its plasma levels were measured enzyme immunoassay (E-1023) using an anti-DCP monoclonal antibody in 514 patients with various diseases. Of 120 HCC, 76 (63%) had abnormal DCP greater than 0.1 arbitrary unit (AU)/ml 58 (48%) showed 0.3 AU/ml. When diagnostic minimum level of AU/ml applied DCP,...

Between December 1,1963 and 31,1965, 39 cases of thyroid cancer were found by systematic, clinical examination members the Adult Health Study sample Atomic Bomb Casualty Commission Hiroshima Nagasaki. Twelve additional identified in who not examined during time period. The occurrence was higher women than men, showed a significant increase with proximity atomic bomb exposure estimated radiation dose received. However, when subjects less 20 years age at rates same for both sexes. Thyroid this...

Four patients with central diabetes insipidus were studied to clarify the mechanism of antidiuretic action carbamazepine (Tegretol). Oral administration Tegretol these resulted in a significant decrease urine volume and an elevation U/P osmolar ratio greater than 1. Antidiuretic hormone (ADH) concentrations plasma also increased normal range after treatment. These studies indicated that drug was acting through release endogenous ADH thereby induced antidiuresis. During course therapy, acute...

Radioimmunoassay of angiotensin I and its appli-cation to the measurement plasma renin activity (PRA) was studied. The assay method consists incubation at 37°C, pH 5.5 for 6 hours with disodium ethylenediamine tetraacetic acid (EDTA) di-isopropyl fluorophosphate (DFP) radioimmunoassay generated during incubation. values PRA determined by present showed a good correlation that bioassay. We examined find ideal conditions in each step this procedure found high specificity, sensitivity...

Several biomechanical studies have shown that the acromioclavicular (AC) ligament prevents posterior translation of clavicle in horizontal plane. In anatomy textbooks, however, AC is illustrated as running straight across joint surface.The does not run surface, and configuration may vary.Descriptive laboratory study.We used 16 pairs shoulder girdles this study. After identifying ligament, we macroscopically investigated orientation attachment measured angle between line perpendicular to...

Effects of coadministration probenecid on pharmacokinetic behaviors famotidine, an H2-receptor antagonist, after oral administration, were studied in eight young, healthy volunteers. They received 20 mg dose famotidine with and without 1500 doses probenecid. The mean area under the serum concentration-time curve up to 10 hours was increased by from 424 +/- 19 (SEM) 768 39 ng.hr/ml. urinary excretion rate unchanged amount excreted urine 24 renal clearance decreased tubular secretion 196.2...

This article aims to clarify the topographical relationships of bronchomediastinal collecting lymph vessels other structures, in particular great vessels, trachea, esophagus and mediastinal pleura. Minute dissection was performed on eight cadavers with special reference converging which form trunks.On right side, trunks were consistently observed both brachiocephalic vein subserous surface pleura (anterior posterior trunks). The pathway from recurrent chain nodes ran laterally behind carotid...

In spite of a similar embryologic origin, the concurrence carotid body tumor and pheochromocytoma is extremely rare; only three cases have been reported in literature. Two additional with examination catecholamine contents tissue were discussed reference to above cases. Carotid adrenal are easily distinguishable by their histologic features. one our two cases, extra-adrenal retroperitoneal containing scanty chromaffin granules negative adrenalin had picture that chemodectoma, which incapable...

Recent reports indicate that organic fertilisers have a suppressive effect on the pathogens of plants grown under hydroponic systems. Furthermore, microorganisms exhibiting antagonistic activity to diseases been observed in This study evaluated corn steep liquor (CSL) controlling lettuce root rot disease [Fusarium oxysporum f.sp. lactucae (FOL)] system. The CSL and Otsuka A (a chemical fertiliser) inhibition FOL terms mycelial growth was tested vivo.

The pes anserinus is composed of a combination tendinous insertions the sartorius, gracilis and semitendinosus muscles. Precise knowledge structures on medial side knee relationships between fascia tendons critical for diagnosis, surgery, development improved operative procedures knee. To obtain precise data layered associated with cruris fibrous bundles attached to them, we dissected nine legs five adult cadavers. We observed superficial longitudinal bundle surface sartorius deep...

Effects of corn steep liquor (organic fertilizer, OF) and conventional chemical fertilizer (CF) on the growth yield bok choy (Brassica rapa var. chinensis) in summer autumn hydroponic growing systems were compared. When OF CF applied with same amount total nitrogen cultivation, there was no significant difference between yields; however, rate slower than CF. twice (OF2), significantly inhibited likely owing to dissolved oxygen deficiency different rates nitrification absorbance by plant...

To investigate the interaction between antidiuretic hormone (ADH) and renin-angiotensin system, plasma ADH renin activity (PRA) were determined in normal subjects (n = 10) under various hydrated states. Four experimental conditions, i.e., water loading, infusion of hypertonic saline, acute dehydration induced by furosemide postural changes, chosen. 1. Upright posture decreased volume 9.5 +/- 0.9% without significant changes osmolality. PRA increased from 5.2 0.7 to 8.3 0.8 ng/ml. However,...