A5022371934- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Cancer and Skin Lesions
- Multiple and Secondary Primary Cancers
- HER2/EGFR in Cancer Research
- Renal cell carcinoma treatment
- Advanced Radiotherapy Techniques
- Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Peptidase Inhibition and Analysis
- COVID-19 diagnosis using AI
- Antibiotics Pharmacokinetics and Efficacy
- Women's cancer prevention and management
- Enzyme function and inhibition
- Histone Deacetylase Inhibitors Research
- Radiopharmaceutical Chemistry and Applications
- Autoimmune Neurological Disorders and Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Kidney Stones and Urolithiasis Treatments
- Management of metastatic bone disease
- Medical Imaging and Pathology Studies
Nippon Medical School Hospital
2017-2024
Nippon Medical School
2008-2023
European Neuroendocrine Tumor Society
2019
Yale Cancer Center
2015-2018
Yale University
2018
Abstract Background Sentinel lymph node biopsy is a standard staging procedure for early axillary node‐negative breast cancer. As an alternative to the currently used radioactive tracers sentinel (SLN) detection during surgical procedure, number of studies have shown promising results using superparamagnetic iron oxide (SPIO) nanoparticles. Here, we developed new handheld, cordless, and lightweight magnetic probe SPIO detection. Methods Resovist (SPIO nanoparticles) were detected by newly...
PIK3CA is associated with tumor progression, and the prevalence of mutation high in breast cancer. Liquid biopsy offers convenient, noninvasive, real-time insight into genetic alteration. In this study, we used liquid to detect mutations patients cancer.We recruited histologically confirmed cancer distant metastases between April 2020 September 2020. Circulating DNA was extracted from plasma (ctDNA) exosomes (exoDNA). (exons 9 20) were analyzed by droplet digital PCR.Of 52 recruited, 16 had...
Accurate pre-operative localization of nonpalpable lesions plays a pivotal role in guiding breast-conserving surgery (BCS). In this multicenter feasibility study, breast were localized using handheld magnetic probe (TAKUMI) and marker (Guiding-Marker System®). The was preoperatively placed within the target lesion under ultrasound or stereo-guidance. Additionally, dye injected subcutaneously to indicate extent tumor excision. Surgeons checked for probe. could detect accurately localize...
Current immunohistochemistry methods for diagnosing abnormal cells, such as cancer require multiple steps and can be relatively slow compared with intraoperative frozen hematoxylin eosin staining, are therefore rarely used examination. Thus, there is a need novel rapid detection methods. We previously demonstrated that functionalized fluorescent ferrite beads (FF beads) magnetically promoted immunoreactions. The aim of this study was to improve the immunoreaction method using antibody-coated...
We suspected that moving a small neodymium magnet would promote migration of the magnetic tracer to sentinel lymph node (SLN). Higher monitoring counts on skin surface before making an incision help us detect SLNs easily and successfully. The present study evaluated enhancement count in SLN detection based movement biopsy (SNB) using superparamagnetic iron oxide (SPIO) nanoparticles.After induction general anesthesia, nanoparticles were injected sub-dermally into subareolar area or...
Epigenetic alterations caused by aberrant DNA methylation have a crucial role in cancer development, and the DNA-demethylating agent decitabine, is used to treat hematopoietic malignancy. Triple-negative breast cancers (TNBCs) shown sensitivity decitabine; however, underlying mechanism of its anticancer effect effectiveness treating TNBCs are not fully understood. We analyzed effects decitabine on nine TNBC cell lines examined genes associated with cytotoxic effects. According we classified...
This exploratory study compared doses of ferucarbotran, a superparamagnetic iron oxide nanoparticle, in sentinel lymph nodes (SLNs) and quantified the SLN load by dose localization. Eighteen females aged ≥20 years scheduled for an biopsy with node-negative breast cancer were divided into two equal groups administered either 1 mL or 0.5 ferucarbotran. Iron content was evaluated handheld magnetometer quantification device. The average 42.8 µg (range, 1.3-95.0; 0.15% injected dose) 21.9...
This study was conducted to elucidate the prognostic significance of BAF57 in patients with endometrial carcinoma. We investigated relationship between immunohistochemical expression and various clinicopathological variables 111 carcinomas. Both univariate multivariate regression analyses were performed. The correlations other including estrogen receptor (ER) p53 examined. high nuclear detected 42 (37.8%) carcinomas, 69 (62.2%) carcinomas defined as having low expression. significantly...
The duration of suction drainage in patients undergoing breast cancer surgery is difficult to predict. uncertainty this poses may complicate the development a clinical pathway for with cancer. In study we attempted identify factors that influence surgery.We examined relationships between and several including type tube 60 primary who underwent surgical resection at Nippon Medical School Hospital 2004 2005. tubes were removed 1 day after daily volume had decreased less than 50 mL or on...
Abstract Purpose This study aimed to evaluate the clinical usefulness of a deep learning-based computer-aided detection (CADe) system for breast ultrasound. Methods The set 88 training images was expanded 14,000 positive and 50,000 negative images. CADe trained detect lesions in real- time using learning with an improved model YOLOv3-tiny. Eighteen readers evaluated 52 test image sets without CADe. Jackknife alternative free-response receiver operating characteristic analysis used estimate...
<h3>Importance</h3> Many large adjuvant clinical trials end up underpowered because of fewer than expected events in the control arm. Ensuring a minimum number would result more informative trials. <h3>Objective</h3> To calculate individualized residual risk estimates using prediction software and assess whether defining eligibility based on threshold could increase reliability trial power calculations compared with criteria tumor size nodal status. <h3>Design, Setting, Participants</h3> We...
To minimize the invasiveness and improve patient's quality of life, sentinel lymph node (SLN) biopsy with magnetic nanoparticles (MNPs) containing superparamagnetic iron oxide is performed on breast cancer patients. Identifying first SLN by quantification amount MNPs can help to investigate metastasis. We developed device for performing during surgery. The compact desktop-size be easily introduced into operation rooms, simple system enables identification SLN. investigated optimum nonlinear...
A 64-year-old woman noticed a lump of the right breast and consulted our outpatient clinic. She had undergone multiple excisional biopsies fibroadenomas in both breasts mastectomy for invasive ductal carcinoma (IDC) left breast. After completing 5 years treatment with adjuvant tamoxifen, she screening annual physical examinations occasional computed tomography. was declared recurrence-free 13 after cancer surgery, although lumps were detected breast, probably due to fibroadenomas....
We describe a 39-year-old woman with metastatic breast cancer who had grade 4 epistaxis induced by bevacizumab. The patient visited our outpatient clinic complaints of lump in her right breast, fatigue, dyspnea, abdominal distention, appetite loss, and weight loss 10 kg over 1 year. Liver dysfunction was detected, elevated levels aspartate aminotransferase (271 IU/L), alanine (100 alkaline phosphatase (4,205 total bilirubin (2.7 mg/dL), direct (2.1 mg/dL). A secondary liver tumor that...
The superior gluteal artery (SGA) perforator (SGAP) flap is used more rarely for breast reconstruction with autologous tissue than other flaps because the SGA often narrow, and SGAP can be short. However, it provides ample fat, including in lean women. To improve its safety utility, preoperative course women who underwent was determined three-dimensional computed tomography angiography.
Background: In patients with clinically node-negative breast cancer, diagnosed palpation and several types of imaging examination, sentinel lymph nodes accurately predict the status other axillary nodes, which determine nature subsequent adjuvant treatment. addition, compared node dissection, sentinel-node biopsy results in less postoperative morbidity, including pain, numbness, swelling, reduced mobility ipsilateral arm. Methods: We analyzed validity procedure using dual-agent injection...
Purpose: To investigate the correlation between SUVmax of FDG-PET/CT and pathological findings including prognostic factors in early-stage T1-T2 breast cancer patients with no LN metastasis. Materials Methods: This retrospective study investigated 75 (mean age 58.9 years; range 30 - 82 years) invasive who underwent for preoperative staging. All subsequent surgery without prior neoadjuvant chemotherapy or endocrine therapy, those were confirmed to have T1- T2-stage by histopathology...
A retrospective study of the real-world use neoadjuvant endocrine therapy (NET) is important for standardizing role NET in breast cancer care.In a consecutive series women with operable who received ≥28 days, associations objectives, outcomes, adjuvant chemotherapy after NET, and survival clinicopathological factors were examined.NET objectives reduction surgical extent 49 patients, avoidance surgery 31, treatment until scheduled 8. The mean duration was 349.5 (range, 34-1,923), 869.8...