A5059827182- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Dysphagia Assessment and Management
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Olfactory and Sensory Function Studies
- Pediatric health and respiratory diseases
- Child Nutrition and Feeding Issues
- Spanish Linguistics and Language Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Healthcare Systems and Public Health
- Health, Education, and Physical Culture
- Infectious Diseases and Mycology
- Urticaria and Related Conditions
- Kruppel-like factors research
- Protein Tyrosine Phosphatases
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- Engineering Technology and Methodologies
- Metabolism and Genetic Disorders
- Obstructive Sleep Apnea Research
- Helicobacter pylori-related gastroenterology studies
- Multisensory perception and integration
University of Fukui
2011-2021
Showa University
2015-2019
Zero to Three
2012
RIKEN Center for Integrative Medical Sciences
2011
RIKEN
2011
Tokyo Women's Medical University
2008-2010
Abstract Background Chronic rhinosinusitis ( CRS ) can be classified into with nasal polyps w NP and without s ). displays more intense eosinophilic infiltration the presence of Th2 cytokines. Mucosal eosinophilia is associated severe symptoms often requires multiple surgeries because recurrence; however, even in ECRS ), clinical course variable. In this study, we wanted to set objective criteria for diagnosis refractory . Methods This was a retrospective study conducted by 15 institutions...
Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility AD. In this study, we collected 2,478 DNA samples including 209 AD patients 729 control subjects from Taiwanese population 513 1027 subject Japanese sequencing genotyping ORAI1. A total of 14 variants 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified. Our results indicated that non-synonymous SNP (rs3741596,...
Abstract Background Allergic rhinitis ( AR ) is a very common disorder peaking in the teenage years that mediated by hypersensitivity responses to environmental allergens. Although it well established ORMDL 3 locus at chromosome 17q21 associated with susceptibility bronchial asthma, genetic influences of polymorphisms allergic are unclear. Objective To examine whether asthma Japanese population. Methods We performed linkage disequilibrium LD mapping using HapMap database and conducted an...
Abstract Background Most patients with nonsteroidal anti‐inflammatory drug‐exacerbated respiratory disease ( NERD ) suffer from recurrence of nasal polyps. However, little is known about the specific cellular and molecular mechanisms contributing to pathogenesis polyp development in particular, especially at baseline when cyclooxygenase 1 inhibitors are not present. The objectives this study were identify proteins involved polyps . Methods We collected tissue aspirin‐tolerant chronic...
Atopic dermatitis (AD) is a common inflammatory skin disease caused by multiple genetic and environmental factors. AD characterized the local infiltration of T helper type 2 (Th2) cells. Recent clinical studies have shown important roles Th2 chemokines, CCL22 CCL17 in pathogenesis AD. To investigate whether polymorphisms gene affect susceptibility to AD, we conducted association functional related variants. We first resequenced found total 39 SNPs. selected seven tag SNPs gene, using two...
The chromosomal region 17q21 harbors the human orosomucoid-like 3 (ORMDL3) gene and has been linked to asthma other inflammatory diseases. ORMDL3 is involved in unfolded protein response (UPR), lipid metabolism, reactions. We investigated effects of overexpression RBL-2H3 cells determine contribution disease development. generated stably overexpressing assess degranulation, transcriptional upregulation interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1...
Summary Oral sensory function is essential for the successful performance of a range ingestion. Although perception object size important in determining degree manipulation, evidence suggests that people does not always perceive oral cavity accurately. The purpose this study was to investigate factors affecting intraoral size. Twenty‐three healthy young volunteers detected cylinders inserted into blindly and identified it from reference set. diameter cross section varied 10 14 mm gap 1 had...
In April 2012, the Center of Special Needs Dentistry (SND) was established at Showa University Dental Hospital to provide function training for children with eating and swallowing disorders. A statistical clinical assessment performed on new patients ≤18 years age who visited over a 1-year period (April 2012–March 2013) assess conditions present initial visit. all, 60 (29 boys, 31 girls, mean (± SD) 4.2±4.1 years, range 0-18 age) were included in study. Most <1 year (32%) most came from one...
唇顎口蓋裂は発生頻度の高い先天異常であり, 治療や療育にはさまざまな分野からのアプローチが必要とされているが, 摂食や口唇閉鎖などの口腔機能面でのアプローチは未だ十分に行われていない. そこで, 唇顎口蓋裂児の口腔機能の発達を解明するために, 小型圧センサを埋め込んだスプーンを用いて片側性唇顎口蓋裂児の口唇正中部, 口唇側方部 (破裂側および非破裂側) の3点から捕食時垂直的口唇圧の測定を行った. 対象は乳歯列完成期の片側性唇顎口蓋裂児 (Cleft群) 23名で, 健常小児 (N群) 25名を対照群とした. 解析項目は, 捕食時口唇圧, 陰圧, 捕食時作用時間, 捕食時圧積分値とし, それぞれについて検討を行った. 捕食時口唇圧はCleft群がN群と比較して正中部で有意に小さかった. 陰圧はCleft群とN群で殆ど差は認められなかった. 捕食時作用時間は, Cleft群がN群と比較して有意に長い値を示した. また, 捕食時圧積分値は両群で有意差はみられず同程度であった. 以上よりCleft群はN群と比較して弱い口唇圧を捕食時の作用時間の長さで代償していることが示唆された.
アレルギー疾患は遺伝要因と環境要因とが複雑に関与して生じる炎症性疾患である。近年のHapMapプロジェクトによる情報基盤の整備，及び高速大量タイピング技術の確立により，大規模で信頼性の高いゲノムワイド症例対照関連解析（GWAS）が行なわれるようになってきた。アレルギーの分野でも遺伝要因が明らかとなってきている。その結果，疾患関連領域には，IL-33，その受容体であるIL1R1，TSLPなどの遺伝子が含まれる事が明らかとなった。これらはアレルギーの病態においてTh2免疫応答を誘導および活性化する自然免疫機構の重要性を示している。一方，関連領域にはIL18R，IL2RBなどのサイトカイン受容体，活性化した制御性T細胞の特異的マーカーであるLRRC32（GARP）も含まれていた。これらGWASの結果はアレルギー疾患における上皮バリアおよび免疫応答機構の重要性を示唆している。これまで，疫学や免疫研究により，呼吸器感染症，吸入抗原に含まれるプロテアーゼ，大気汚染による上皮傷害は気道アレルギー発症の誘因でもあり増悪要因にもなることが示されている。また，病原体成分や化学物質などのdanger...
A Special Needs Dental Center （hereafter referred to as the Center） was established at Showa University Hospital in April 2012 treat patients who need special care. In cooperation with Division of Dentistry for Persons Disabilities, Hygiene and Oral Health is mainly engaged treatment eating swallowing disorders. It has been five years since establishment Center. The present study aimed establish an effective medical support method through a comparative changes patient trends. total 65...