A5070585553- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- Nasal Surgery and Airway Studies
- IL-33, ST2, and ILC Pathways
- Facial Trauma and Fracture Management
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Infectious Diseases and Mycology
- Drug-Induced Adverse Reactions
- Traumatic Ocular and Foreign Body Injuries
- Neurofibromatosis and Schwannoma Cases
- RNA Interference and Gene Delivery
- Cystic Fibrosis Research Advances
- Plant Reproductive Biology
- Mast cells and histamine
- Oral and gingival health research
- Eosinophilic Esophagitis
- Congenital Ear and Nasal Anomalies
- Dysphagia Assessment and Management
- Contact Dermatitis and Allergies
Osaka University
2003-2024
University of Fukui
2015-2024
Asahikawa Medical University
2024
Northwestern University
2018-2022
Nagoya City University
2019
Uji Hospital
2018
Hokkaido University
2015
University of Tsukuba
2009-2013
Abstract Background Chronic rhinosinusitis ( CRS ) can be classified into with nasal polyps w NP and without s ). displays more intense eosinophilic infiltration the presence of Th2 cytokines. Mucosal eosinophilia is associated severe symptoms often requires multiple surgeries because recurrence; however, even in ECRS ), clinical course variable. In this study, we wanted to set objective criteria for diagnosis refractory . Methods This was a retrospective study conducted by 15 institutions...
Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10−8) in GWAS were further genotyped an independent samples (818 cases 1,032 controls) Korean (835 421 controls). SNP rs987870, located between HLA-DPA1 HLA-DPB1, was consistently associated 3 populations (Pcombined = 2.3×10−10, odds...
Allergic rhinitis (AR) is recognized as a major health problem worldwide, and its prevalence depends on the age range of subjects. The aims this study were to determine current AR, effects IgE sensitization inhalant allergens, serum total levels in Japanese subjects.We conducted survey 1,540 subjects between 20 49 years 2006 2007 examined AR 7 common aeroallergens. We measured specific was determined based symptoms, predominantly nose eyes, caused by aeroallergens mentioned questionnaire any...
In this study, we found Cystatin SN (CST1), a type 2 cystatin subfamily member, to be highly expressed in nasal polyps from patients with intractable chronic rhinosinusitis (CRS) polyps, using whole-transcript analysis next-generation sequencing. Eosinophilic CRS (ECRS) involves that are refractory and recur immediately after endoscopic sinus surgery. We hypothesized CST1 may contribute the pathogenesis of ECRS. examined expression ECRS by assessing mRNA levels real-time PCR...
Abstract A predominant protein of human eosinophils is galectin-10 (Gal-10), also known as Charcot-Leyden crystal (CLC-P) because its remarkable ability to form crystals (CLCs), which are frequently found in tissues from patients with eosinophilic disorders. CLC-P/Gal-10 highly expressed and considered a biomarker eosinophil involvement inflammation. However, the intracellular sites where large pools constitutively reside still unclear, whether this derived or not granules remains be...
The generation of induced pluripotent stem cells (iPSCs) by introducing reprogramming factors into somatic is a promising method for cell therapy in regenerative medicine. Therefore, it desirable to develop minimally invasive simple create iPSCs. In this study, we generated human nasal epithelial (HNECs)-derived iPSCs gene transduction with Sendai virus (SeV) vectors. HNECs can be obtained from subjects noninvasive manner, without anesthesia or biopsy. addition, SeV carries no risk altering...
Seasonal allergic rhinitis (SAR) to the Japanese cedar, Cryptomeria japonica (JC) pollen is an IgE-mediated type I allergy affecting nasal mucosa. However, molecular events underlying its development remain unclear. We sought identify SAR-associated altered gene expression in epithelial cells during natural exposure JC pollen. recruited study participants 2009 and 2010 collected between February April, which period of dispersion. Fifteen patients with SAR-JC 13 control subjects were enrolled...
In Eosinophilic chronic rhinosinusitis (ECRS), it is difficult to estimate the refractoriness and recurrence risk for each patient. Fraction of exhaled nitric oxide (FeNO) known as a biomarker eosinophilic inflammation in lower airway. It has been reported that nasal NO some crucial functions upper airways. However, airway, paranasal sinuses, usefulness measurement remains controversial. The purpose this study identify ECRS involvement pathogenesis ECRS.We compared levels ECRS, non-ECRS,...
Most of the previously reported loci for total immunoglobulin E (IgE) levels are related to Th2 cell-dependent pathways. We undertook a genome-wide association study (GWAS) identify genetic responsible IgE regulation. A 479,940 single nucleotide polymorphisms (SNPs) were tested with serum in 1180 Japanese adults. Fine-mapping SNP imputation demonstrated 6 candidate regions: PYHIN1/IFI16, MHC classes I and II, LEMD2, GRAMD1B, chr13∶60576338 regions. Replication these each region was assessed...
Summary Background Chronic rhinosinusitis ( CRS ) is a heterogeneous chronic inflammatory disease generally divided based on the presence or absence of nasal polyps NP s). One features s excessive fibrin deposition, which associated with down‐regulation tissue plasminogen activator (t‐ PA in s. As t‐ expressed epithelial cells, and epithelium readily accessible to topical therapies, identifying compounds that can mediate induction would be potential new strategy for treatment Objective The...
Coronavirus disease 2019 (COVID-19) has caused a global pandemic. Higher expression of the virus receptor angiotensin-converting enzyme 2 (ACE2) in nasal mucosa may be associated with high transmissibility and asymptomatic infection. In COVID-19, elucidation determinants ACE2 at tissue level is crucial. The development strategies to downregulate epithelial cells might reduce transmission useful as novel therapeutic approach.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is often comorbid asthma and resistant to therapeutic interventions. We recently reported that excessive fibrin deposition caused by impairment of fibrinolysis might play pivotal role in forming polyp. Nattokinase (NK), a serine protease produced Bacillus subtilis, has been be strong fibrinolytic enzyme. NK could promising drug candidate for use the treatment both CRSwNP asthma. The objective this study was investigate effects on polyp...
Background: The pathological features of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) tissues include an eosinophilic infiltration pattern (eosinophilic CRS (ECRS)) or a less (non-ECRS). Recently, it has been suggested that 15-lipoxygenase 1 (15-LOX-1) may have significant roles in allergic disease; however, the significance 15-LOX-1 is not well understood. objective this study was to demonstrate expression CRS. Methods: mRNA levels and periostin were measured by quantitative...
Seasonal allergic rhinitis (SAR) to Japanese cedar (Cryptomeria japonica; JC) is an IgE-mediated type I allergy affecting the nasal mucosa. However, molecular mechanisms that underlie SAR are only partially understood. The aim of study was identify novel genes related during natural exposure pollens, by using microarray analysis.Subjects were 32 patients and 25 controls. Total RNA extracted from CD4(+) T cells isolated peripheral blood mononuclear subjected analysis with Illumina Human Ref8...
Background Allergic diseases are an important health problem for children and adults. It is to know how allergic develop remit from infancy adolescence. Early intervention effective in treating diseases. Objective We performed a large-scale questionnaire survey of high school students Fukui Prefecture, Japan, analyzed the factors associated with development remission Methods A total 21,802 participated epidemiologic survey, valid response rate was 89.3% (19,461). applied inverse probability...
Conclusions: We conclude that the capsaicin inhalation test is useful to directly assess cough reflex and sensation around larynx, while it indirectly reflects central nervous system function. Objectives: To understand state of before patients with dysphagia start eating. Methods: studied by in 21 12 healthy persons without dysphagia. Results: The control group showed a at concentration 2.61 μM (0.98–7.80), mild did so 7.28 (1.95–15.6), those moderate 22.07 (15.6–62.5), severe 71.75...
Abstract Background Most patients with nonsteroidal anti‐inflammatory drug‐exacerbated respiratory disease ( NERD ) suffer from recurrence of nasal polyps. However, little is known about the specific cellular and molecular mechanisms contributing to pathogenesis polyp development in particular, especially at baseline when cyclooxygenase 1 inhibitors are not present. The objectives this study were identify proteins involved polyps . Methods We collected tissue aspirin‐tolerant chronic...
Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiology desirable in a clinical setting. As IgG4 production regulated by type cytokines, we sought to determine whether levels can be used as biomarker for CRS. Association between and clinicopathological factors was analyzed 336 patients. Receiver operating characteristics (ROC) analysis performed cut-off value...