A5023187304- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Drug-Induced Adverse Reactions
- IL-33, ST2, and ILC Pathways
Northwestern University
2017-2020
Background Chronic rhinosinusitis (CRS) is strongly associated with comorbid asthma. This study compares early‐onset and late‐onset asthma in a CRS population using patient‐reported clinical characteristics. Methods At enrollment into registry, patients completed the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), Asthma Control (ACT), mini‐Asthma Quality of Life Questionnaire (miniAQLQ), 29‐item Patient‐Reported Outcomes Measurement Information System (PROMIS‐29), medication use questionnaires....
Summary Background Chronic rhinosinusitis ( CRS ) is a heterogeneous chronic inflammatory disease generally divided based on the presence or absence of nasal polyps NP s). One features s excessive fibrin deposition, which associated with down‐regulation tissue plasminogen activator (t‐ PA in s. As t‐ expressed epithelial cells, and epithelium readily accessible to topical therapies, identifying compounds that can mediate induction would be potential new strategy for treatment Objective The...
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) has a high propensity for recurrence. Studies suggest that eosinophilia influences disease severity and surgical outcomes, but the selection of sinonasal site measuring not been examined. The aim this study was to investigate how region‐specific tissue affects radiographic severity, comorbidity prevalence, polyp recurrence risk following sinus surgery. Methods Eosinophil cationic protein (ECP) levels in uncinate (UT) (NP)...