A5049211831- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Eosinophilic Esophagitis
- Urticaria and Related Conditions
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Immune cells in cancer
- NF-κB Signaling Pathways
- interferon and immune responses
- Allergic Rhinitis and Sensitization
- Autoimmune and Inflammatory Disorders Research
- Pharmacological Effects of Natural Compounds
- Food Allergy and Anaphylaxis Research
- Liver physiology and pathology
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Research on Leishmaniasis Studies
- Toxin Mechanisms and Immunotoxins
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
Hyogo University
2024
Hyogo Medical University
2008-2020
Bipar
2006-2013
Miyazaki Agricultural Research Institute
2012
Japan Science and Technology Agency
2001-2010
Kumamoto University
2006
Tokushima Prefectural General Education Center
2003
Mie University
2002
The University of Tokyo
1997-2002
Tokyo University of Science
2002
The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to proinflammatory cytokine. ICE was also shown cleave of interferon-γ inducing factor (IGIF) at authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE −/− ) Kupffer cells synthesized but failed process it into active form. Interferon-γ were diminished in sera mice exposed Propionibacterium acnes...
Abstract Monocytes/macrophages exposed to LPS show reduced responses second stimulation with LPS, which is termed tolerance. In this study, we investigated molecular mechanism of tolerance in macrophages. Mouse peritoneal macrophages pre-exposed exhibited production inflammatory cytokines a time- and dose-dependent manner. Activation neither IL-1 receptor-associated kinase nor NF-κB was observed that became tolerant by pretreatment, indicating the proximal event Toll-like receptor 4...
Abstract IL-18 is a product of macrophages and with IL-12 strikingly induces IFN-γ production from T, B, NK cells. Furthermore, synergize for Th1 cells, although this combination fails to affect Th2 In study, we show that promptly synergistically induce T B cells develop into IFN-γ-producing without engaging their Ag receptors. We also studied the mechanism underlying differences in responsiveness between Pretreatment or rendered them responsive IL-18, which cell proliferation production....
Systemic administration of IL-18 induces polyclonal IgE responses by causing NKT cells to express CD40 ligand and produce IL-4. Administration IL-33 also response, although the mechanism underlying response is unclear. Here, we compared effects on bone marrow-derived mast basophils as well non-polarized Th2-polarized CD4+ T in vitro. Basophils, comprising IL-18Rα+ (14.2%) IL-33Rα+ (34.6%), cells, (2.0%) (95.6%), IL-4, IL-6, IL-13, granulocyte macrophage colony-stimulating factor (GM-CSF)...
NK cells, non-T non-B immune effector lymphocytes, are localized in many organs, including liver, as well the circulation. To investigate regulatory mechanism of killing apparatus hepatic we established IL-2-dependent cell clones from liver lymphocytes BALB/c nude mice. generate clones, incubated with a high dose IL-2 presence irradiated Kupffer feeder cells and source IL-12, originally identified stimulatory factor. Unless were both no growth was observed. Hepatic this line by limiting...
Transgenic mice expressing the mouse interleukin 33 (IL-33) gene driven by a keratin 14 promoter were generated. The skin-selective expression of IL-33 was enhanced, and intense immunofluorescence for evident in nuclei epidermis. Spontaneous itchy dermatitis developed those at 6–8 wk age specific pathogen-free conditions. In lesional skin, epidermis thickened eosinophils infiltrated with increased eosinophil peroxidase major basic protein genes. Mast cells also abundant there, blood...
Interleukin 18 (IL-18), originally called interferon (IFN)-γ-inducing factor, is a recently cloned cytokine of approximately kDa synthesized by Kupffer cells and activated macrophages. The major activity associated with this molecule the induction IFN-γ production from anti-CD3-activated T helper 1 in presence IL-12. B produce IgG1 IgE when stimulated anti-CD40 IL-4. Here we show that combination IL-12 IL-18 induces anti-CD40-activated to IFN-γ, which inhibits IL-4-dependent enhances IgG2a...
When animals are infected with helminthic parasites, resistant hosts show type II helper T immune responses to expel worms. Recently, natural (NH) cells or nuocytes, newly identified innate lymphoid cells, shown express ST2 (IL-33 receptor) and produce IL-5 IL-13 when stimulated IL-33. Here we the relevant roles of endogenous IL-33 for Strongyloides venezuelensis infection-induced lung eosinophilic inflammation by using Il33 −/− mice. Alveolar epithelial (ATII) in their nucleus. Infection S....
An analysis of the change in strain distribution intervertebral discs present after anterior cervical decompression and fusion by an original method. The analytical results were compared to occurrence herniation disc on magnetic resonance imaging.To elucidate influence unfused segments spine.There is no consensus regarding exact significance biomechanical segment surgery.Ninety-six patients subjected for examined. Shear longitudinal analyzed pre- postoperative lateral dynamic routine...
Abstract TNF-related apoptosis-inducing ligand (TRAIL), a new member of TNF family, induces apoptotic cell death various tumor cells. We recently showed that TRAIL mediates perforin- and Fas (FasL)-independent cytotoxic activity human CD4+ T clones. In the present study, we investigated expression function on murine lymphocytes by using newly generated anti-murine mAbs. Although freshly isolated T, B, or NK cells did not express detectable level their surface, remarkable was induced...
IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and T(h)1 response. has structural homology to IL-1, particularly IL-1beta. IL-18R, composed of IL-1R-related protein (IL-18Ralpha) IL-1R accessory protein-like (IL-18Rbeta), belongs the family. Furthermore, IL-18R at least partly shares signal transducing system with IL-1R. Thus, IL-18-IL-18R striking similarity IL-1-IL-1R system. For this reason, we regarded it investigate whether, like IL-18, IL-1beta...
Abstract Listeria monocytogenes (LM), a facultative intracellular Gram-positive bacterium, often causes lethal infection of the host. In this study we investigated molecular mechanism underlying LM eradication in early phase infection. Upon with LM, both IL-12 and IL-18 were produced, then they synergistically induced IFN-γ production, leading to normal clearance knockout (KO) mice highly susceptible IL-12/IL-18 double also susceptible. Their susceptibility was less than that KO mice, but...
IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and Th1 response. Recently IL-1R-related protein (IL-1Rrp) has been cloned as the receptor for IL-18. However, functional of IL-1Rrp still controversial due to its low affinity well possibility presence another high-affinity binding receptor. In present study, we have generated characterized IL-1Rrp-deficient mice. The murine rIL-18 was not detected Th1-developing splenic CD4+ T cells isolated from...