Non-alcoholic fatty liver disease is frequently associated with type 2 diabetes, and constitutes an important risk factor for the development of hepatic fibrosis hepatocellular carcinoma. Because there remains no effective drug therapy non-alcoholic we evaluated efficacy sodium-glucose cotransporter inhibitor.In present pilot, prospective, non-randomized, open-label, single-arm study, effect 100 mg canagliflozin administered once daily 12 months on serological markers, body composition...

The purposes of this study were to investigate cavity surfaces morphologically, and compare microleakage at cavities prepared by Er:YAG laser after composite resin restoration versus conventional mechanical treatment in human primary teeth vitro.There have been few reports on irradiation.A total 30 (class V) used. Half the an system 300 mJ pulse energy 4 Hz, other half with a high-speed diamond bur. Five from each group investigated scanning electron microscopy (SEM) histopathological...

Mammalian transcriptome analysis has uncovered tens of thousands novel transcripts unknown function (TUFs). Classical and recent examples suggest that the majority TUFs may underlie vital intracellular functions as non-coding RNAs because their low coding potentials. However, only a portion have been studied to date, functional significance remains mostly uncharacterized. To increase repertoire TUFs, we screened for whose expression is controlled during differentiation pluripotent human...

Although it is known that osteoclasts are multinucleated cells responsible for bone resorption, the mechanism by which their size regulated unclear. We previously reported an actin‐rich superstructure, termed zipper‐like structure, specifically appears during fusion of large osteoclast‐like (OCLs). Actin cytoskeleton reorganization in a signaling network includes macrophage colony‐stimulating factor (M‐CSF) receptor, proto‐oncogene, Src, and small GTPases. Here, we examined role actin...

Summary The present study examined the association of denture quality and health-related life (HRQoL) in patients with removable dentures. In a 171 consecutive partial dentures or complete (mean age: 68·0 ± 9·3 years) at university-based prosthodontic clinic, dentists rated two aspects (stability aesthetics) using 100-mm visual analog scale (VAS). HRQoL was evaluated mental physical component summary (MCS PCS) scores Medical Outcomes Study Short-Form 36-Item Health Survey (SF-36). Oral...

The xenoestrogenic substance bisphenol-A is widely used as a synthetic precursor of resin monomers, such diglycidyl methacrylate. Reports describing the release from polymerized into saliva have aroused considerable concern regarding exposure to xenoestrogen by dental treatment. purpose present study was demonstrate reliable methodology detecting trace amounts in materials. Bisphenol-A separable methacrylate, which often employed principal dimethacrylate monomer, selective extraction with...

Abstract Oncolytic vaccinia viruses have promising efficacy and safety profiles in cancer therapy. Although antitumor activity can be increased by manipulating viral genes, the relative of individual modifications has been difficult to assess without side-by-side comparisons. This study sought compare initial after intravenous administration five virus variants same Western Reserve backbone thymidine kinase gene deletion RIP-Tag2 transgenic mice with spontaneous pancreatic neuroendocrine...

Gingivitis commonly progresses to periodontitis in permanent dentition but rarely deciduous teeth. Little is known about the biochemical differences between gingiva of and Here, we compared protein profiles gingival crevicular fluids (GCF) from teeth.Forty children with mixed (Hellman's dental age IIIA) were selected GCF samples collected cuspids central incisors maxilla. Pairs labelled using isobaric tags permit quantitative comparison abundance liquid chromatography-electron spray...

The anti-bone resorptive drugs denosumab, an anti-human-RANKL antibody, and zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, have recently been applied for treatment of pediatric patients with bone diseases, though details regarding their effects in growing children yet to be fully elucidated. In the present study, we administered these anti-resorptive mice from age 1 week continued once-weekly injections total 7 times. Mice that received anti-RANKL antibody displayed normal...

The rigidity of an injection-molded isotactic polypropylene (PP) containing 1,3:2,4-bis-o-(4-methylbenzylidene)-D-sorbitol (MDBS) as a crystal nucleating agent can be enhanced by selection appropriate processing conditions. A new method differential scanning calorimetry measurements showed that the dissolution temperature 0.4 wt.% MDBS in molten PP is around 210°C. When injection molding was performed below temperature, for example, 190°C, molecular orientation greatly enhanced. Although...

This study determined the influence of intravenous (i.v.) oncolytic vaccinia virus mpJX-594 (mpJX) on antitumor activity anti-programmed death receptor-1 antibody (aPD1) in functional and metastatic pancreatic neuroendocrine tumors (PanNETs). One i.v. dose mpJX, engineered for mice with same plasmid design as clinical Pexa-Vec, was administered alone or repeated dosing aPD1 (mpJX+aPD1) to two contrasting genetic models PanNET: one developing benign insulin-secreting (RIP1-Tag2;C57BL/6J mice)...

The purpose of the present study was to investigate efficacy dentin adhesives and examine acid resistance in primary permanent teeth. evaluated by SEM observation measuring wall-to-wall polymerization contraction gap hardness before after conditioning. detailed mechanism bonding same both

To evaluate the ease of manipulation and durability 11 commercially available silicone-based resilient denture liners, extrusion force, hardness, weight change, bond strength were determined. Extrusion force from cartridge each material ranged 0.25 to 1.26MPa at an rate 1cm/min. Durometer after set materials stored in distilled water 37°C for one day, A5.9 A47.7, four weeks their values increased by 4.0 275%. Bond 1.01 2.88MPa but decreased 0.59 1.99MPa 10, 000 thermal cycles. These results...

The junctional epithelium (JE) is at the front site of defense against microorganisms. However, immunological characteristics JE and migrating cells within are unclear. We examined immunohistochemical expression cell adhesion molecules(CAMs) on surface markers cells. In gingival epithelium, only expressed intercellular molecule-1 (ICAM-1). Three distinct layers in could be identified by intensities ICAM-1 expression; both side (ICAM-1high) facing tooth or oral (OE), middle layer (ICAM-1low)....

Histamine receptors are densely expressed in the mesencephalic trigeminal nucleus (MesV) and motor nucleus. However, little is known about functional roles of neuronal histamine controlling oral-motor activity. Thus, using whole-cell recording technique brainstem slice preparations from Wistar rats aged between postnatal days 7 13, we investigated effects on MesV neurons innervating masseter muscle spindles motoneurons (MMNs) that form a reflex arc for jaw-closing reflex. Bath application...

Qualitative and quantitative analyses were conducted on four kinds of resin-modified glass ionomer (RMGI) cement liquids, LC, LC II, III (hereinafter referred to as LCs) VM, using HPLC laser Raman spectroscopic methods. revealed that among the RMGI liquids LCs contain 31-32% HEMA (2-Hydroxyethyl methacrylate), VM contains 18% same. The composition varied significantly between manufacturers. In analyses, spectra various ratios polyacrylic acid measured, calculations made peak intensity C=C...

Many macrophages are recognized in dental pulp. However, their precise functional roles and the origin not well understood.In this study, we analyzed characterization localization of pulp during tooth development by immunohistochemistry immunoelectron microscopy. The first mandibular molars at 1 week finished crown formation 6 weeks root formation. In papilla week, many CD68+ cells were detected. Some invaded into odontoblastic layer tip cusp. A few MHC class II+cells localized papilla. Most...

Abstract In the present study, a novel crystalline nucleating agent for isotactic polypropylene (PP) comprising calcium salt of 4‐methyl‐cyclohexane‐1,2‐dicarboxylic acid (MHPA‐Ca) is developed. The performance evaluated by determining crystallization temperature and isothermal period PP differential scanning calorimetry, comparing them with those obtained using cyclohexane‐1,2‐dicarboxylic (HHPA‐Ca), which one most effective agents PP. results demonstrate that ability MHPA‐Ca much stronger...