A5061811305- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Platelet Disorders and Treatments
- Skin and Cellular Biology Research
- Dermatology and Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Dermatological and Skeletal Disorders
- Acute Kidney Injury Research
- Medical Malpractice and Liability Issues
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Ion Transport and Channel Regulation
- Renal function and acid-base balance
- Immunotherapy and Immune Responses
- Muscle and Compartmental Disorders
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Bacterial Identification and Susceptibility Testing
- Disaster Response and Management
- Oral and gingival health research
- Contact Dermatitis and Allergies
- Virology and Viral Diseases
Sulaimani Polytechnic University
2025
Tufts University
2017-2024
Taibah University
2024
Alexandria University
2024
University of Mosul
2023
GIFT University
2023
University Hospital Galway
2017-2021
University of South Wales
2021
Beaumont Hospital
2020
Université Paris Cité
2018
Human T-cell-mediated autoimmune diseases are genetically linked to particular alleles of MHC class II genes. Susceptibility pemphigus vulgaris (PV), an disease the skin, is a rare subtype HLA-DR4 (DRB1*0402, 1 22 known DR4 subtypes). The PV-linked differs from rheumatoid arthritis-associated (DRB1*0404) only at three residues (DR beta 67, 70, and 71). caused by autoantibodies against desmoglein 3 (DG), T cells thought trigger autoantibody production this keratinocyte adhesion molecule....
Pemphigus vulgaris (PV) is a rare, potentially fatal, autoimmune disease that affects the skin and mucous membranes. The PV antigen (PVA) has been characterized as desmoglein 3. patients carry HLA-DR4- or HLA-DR6-bearing extended haplotypes. We recently demonstrated with active have high titers of autoantibodies IgG1 IgG4 subclasses. Patients in remission, healthy unaffected relatives, some MHC-matched normal individuals low levels autoantibodies, which are only. Furthermore, intraperitoneal...
Previous studies demonstrated that HLA-DR4 was markedly increased among Ashkenazi Jewish patients with pemphigus vulgaris (PV), almost entirely as the common extended haplotype [HLA-B38, SC21, DR4, DQw8] or HLA-B35, SC31, DQw8, and HLA-DR4, DQw8 distributed in a manner consistent dominant expression of class II (D-region D-region-linked) susceptibility gene. In present study major histocompatibility complex (MHC) haplotypes 25 non-Jewish PV patients, found 12 DRw6, DQw5 15. Only 3 had...
Mucous membrane pemphigoid or cicatricial is a mucocutaneous blistering disease characterized by autoantibodies to different molecules in the basement zone. Our objectives were identify target antigen recognized sera from 20 untreated patients with limited oral cavity, and determine pathogenicity of pemphigoid, an organ culture model. We conducted indirect immunofluorescence, immunoblot, immunoprecipitation assays, accompanying absorption experiments, using normal human skin, conjunctiva...
Pemphigus vulgaris (PV) is a potentially fatal autoimmune disease characterized by the presence of in vivo deposition antibodies against cell surface antigens desmoglein 1 and 2 epidermis.To report treatment outcomes pregnant PV patients treated with intravenous immunoglobulin (IVIg) therapy.Eight active during pregnancy were treated. Patients dose g/kg/cycle. Seven for months on post-partum basis. Main outcome measures as follows: (i) outcome; (ii) neonatal pemphigus; (iii) flare; (iv)...
Cicatricial pemphigoid is a heterogeneous group of autoimmune subepidermal blistering diseases associated most commonly with autoantibodies to bullous (BP)180 and less frequently those laminin 5 or type VII collagen. In addition, few cases have been described the beta4 subunit alpha6beta4 integrin. We describe patient extensive disease ocular, oral, pharyngeal, laryngeal genital mucous membranes that healed scarring conjunctivae. IgG bound dermal-epidermal junction on direct...
Summary Oral pemphigoid (OP) is a chronic autoimmune disease, involving the oral cavity, characterized by homogenous linear deposition of immunoglobulins, complement, or both along basement membrane zone (BMZ) and subepithelial blister formation. The α6/β4 heterodimer an integrin family adhesion receptors, which mediates basal cell to matrix interactions. Recent evidence suggests pathophysiologic role for antibodies against human α6 in formation OP, organ culture studies. Fifty percent OP...
Fourteen of 1,500 patients whose serum samples were evaluated by indirect immunofluorescence microscopy had demonstrable titers anti-intercellular substance (ICS) antibodies in the absence clinical or histologic evidence pemphigus. The anti-ICS absorbed A and B blood group antigens nine 14 patients. In five patients, unchanged after absorption with substances. All these cicatricial bullous pemphigoid on clinical, histologic, immunopathologic examination. Clinical pemphigus did not develop...
Pemphigus vulgaris (PV) is an autoimmune blistering disease that affects the skin and multiple mucous membranes, caused by antibodies to desmoglein (Dsg) 1 3. Natural killer (NK) cells have a role in autoimmunity, but their PV not known. NK peripheral blood leucocytes (PBL) of 15 untreated Caucasian patients with active were studied compared healthy controls for expression major histocompatibility complex (MHC) class II co-stimulatory molecules. CD56+ CD16- CD3- or CD16+ from PBL co-express...
Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that caused by antibodies binding to type VII collagen within anchoring fibrils. It rare with an incidence of 0.25 cases per 1,000,000 population.The objective this study report the treatment outcomes intravenous immunoglobulin (IVIg) therapy in 10 patients severe and widespread EBA non-responsive conventional therapy.Patients were treated according protocol published Consensus Statement treat autoimmune...
Journal Article Comparison of immunological parameters in patients with pemphigus vulgaris following rituximab and IVIG therapy Get access R.J. Feldman, Feldman Center for Blistering Diseases, 70 Parker Hill Ave, Suite 208, Boston, MA 02120, U.S.A Search other works by this author on: Oxford Academic Google Scholar W.G. Christen, Christen Harvard School Public Health, Division Preventive Medicine, Brigham Women's Hospital, Medical School, MA, A.R. Ahmed Razzaque Ahmed. E‐mail:...
Thirteen patients with recurrent severe widespread recalcitrant bullous pemphigoid (BP) were studied. These had been initially treated prednisone and azathioprine, clinically responded. However, they frequently continued to have flare‐ups or activation of the disease while still on treatment high doses these drugs. The addition dapsone, as an adjuvant treatment, helped produce a complete clinical remission in 12 (92%). In addition, there was statistically significant difference median dose...
Bullous pemphigoid (BP) has been reported in association with malignant neoplasms of the urinary tract, lung, genitalia, breast, pancreas, gastrointestinal (GI) skin, and lymphoreticular system.<sup>1</sup>The course BP usually does not parallel neoplasm. The neoplasm may be evident at onset or present as an incidental finding postmortem examination.<sup>2</sup> Carcinoembryonic antigen (CEA) levels greater than 2.5 ng/ml have serum samples from patients pancreatic, colonic, rectal, gastric,...
Mucous membrane pemphigoid (MMP) is a mucocutaneous vesiculobullous autoimmune disease characterized by autoantibodies to components of the basement zone (BMZ). Recently, it has been reported that patients with MMP who have laminin 5, known as anti-epiligrin cicatricial (AECP) high incidence malignancy.The purpose this study was determine association between malignancy and in antibodies beta4 integrin.The cancer studied 79 and/or ocular (OCP) had human integrin subunit. In each patient,...