A5083529701- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Skin and Cellular Biology Research
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders
- Psoriasis: Treatment and Pathogenesis
- Dermatological and Skeletal Disorders
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Cancer and Skin Lesions
- Chronic Lymphocytic Leukemia Research
- Nonmelanoma Skin Cancer Studies
- Mycobacterium research and diagnosis
- Cutaneous lymphoproliferative disorders research
- Skin Diseases and Diabetes
- Food Allergy and Anaphylaxis Research
- Oral Health Pathology and Treatment
- Infectious Diseases and Tuberculosis
- NF-κB Signaling Pathways
Guy's and St Thomas' NHS Foundation Trust
2010-2024
Guy's Hospital
1991-2023
St Thomas' Hospital
2009-2023
King's College London
2009-2022
St. John's School
2020
St John's Hospital
2011-2020
Institute of Dermatology
2009
National Health Service
2008
National Institute for Health Research
2007-2008
St. Thomas Hospital
2007
Anti-tumour necrosis factor (TNF) monoclonal antibodies or soluble TNF receptors have become an invaluable treatment against chronic inflammatory diseases, such as rheumatoid arthritis, bowel disease and psoriasis. Individuals who are treated with antagonists at increased risk of reactivating latent infections, especially tuberculosis (TB). Following antagonist therapy, the relative for TB is up to 25 times, depending on clinical setting used. Interferon-γ release assays or, alternative in...
Most tissues develop from stem cells and precursors that undergo differentiation as their proliferative potential decreases. Mature differentiated rarely proliferate are replaced at the end of life by new derived precursors. Langerhans (LCs) epidermis, although myeloid origin, were shown to renew in independently bone marrow, suggesting existence a dermal or epidermal progenitor. We investigated mechanisms involved LC development homeostasis. observed single wave was recruited epidermis mice...
Background: Photodynamic therapy (PDT) is increasingly used as a noninvasive treatment for nodular basal cell carcinoma (BCC), without sound evidence base.Objective: To compare topical PDT, with the use of sensitizer methyl aminolevulinate, and standard excision surgery in BCC.Design: Prospective, randomized study.Setting: University dermatology departments.Patients: A total 101 adults previously untreated BCC.Interventions: Patients received aminolevulinate PDT (n=52) or (n=49).The was...
Pemphigus encompasses a group of life-threatening autoimmune bullous diseases characterized by blisters and erosions the mucous membranes skin. Before era immunosuppressive treatment, pemphigus was almost always fatal. Due to its rarity, only few randomized controlled therapeutic trials are available. Recently, rituximab has been approved as first-line treatment for moderate severe vulgaris in Europe United States.The Autoimmune blistering Task Force European Academy Dermatology Venereology...
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Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether strategy of starting treatment doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over oral corticosteroids.We did pragmatic, multicentre, parallel-group randomised controlled trial adults bullous (three or more blisters at two sites and linear basement membrane IgG C3). Participants were randomly assigned to (200 mg per day) prednisolone (0·5 mg/kg...
Abstract Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or, frequently, generalized bullous lesions. A subset patients only develops excoriations, prurigo‐like lesions, eczematous and/or urticarial erythematous The disease, which significantly associated neurological disorders, has high morbidity severely impacts quality life. Objectives methodology...
Endothelial leucocyte adhesion molecule-1 (ELAM-1) is a recently described endothelial surface glycoprotein which inducible by interleukin 1 (IL-1), tumour necrosis factor-alpha (TNF-alpha) or bacterial lipopolysaccharide (LPS). Using an immunohistochemical technique and monoclonal antibody (1.2B6) specific for ELAM-1 we have found marked vascular expression of in many cutaneous inflammatory disorders, including allergic contact dermatitis, atopic dermatitis psoriasis, dermal infiltrates...
Anti-tumour necrosis factor (TNF)alpha treatments improve outcome in severe rheumatoid arthritis (RA) and are efficacious psoriasis psoriatic arthritis. However recent case reports describe occurring as an adverse event patients with RA receiving anti-TNFalpha therapy.We aimed to determine whether the incidence rate of was higher treated therapy compared those traditional disease-modifying antirheumatic drugs (DMARDs). We also rates between three licensed for RA.We studied 9826...
Resting epidermal keratinocytes contain large amounts of interleukin 1 (IL-1), but the function this cytokine in skin remains unclear. To further define role IL-1 cutaneous biology, we have generated two lines transgenic mice (TgIL-1.1 and TgIL-1.2) which overexpress alpha basal keratinocytes. There was high-level tissue-specific expression transgene mRNA protein quantities were liberated into circulation from epidermis both lines. TgIL-1.1 mice, had highest level expression, developed a...
B cells emerge from the bone marrow as transitional (TS) that differentiate through T1, T2, and T3 stages to become naive cells. We have identified a bifurcation of human cell maturation T1 stage forming IgMhi IgMlo developmental trajectories. T2 higher expression α4β7 integrin lower IL-4 receptor (IL4R) compared with branch are selectively recruited into gut-associated lymphoid tissue. also share transcriptomic features marginal zone (MZBs). Lineage progression MZBs via an trajectory is by...
Abstract Background Paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare disease with mucocutaneous and multi‐organ involvement. PNP/PAMS typically associated lymphoproliferative or haematological malignancies, less frequently solid malignancies. The mortality rate of elevated owing to the increased risk severe infections disease‐associated complications, such as bronchiolitis obliterans. Objectives These guidelines summarize...
Following skin sensitization a proportion of epidermal Langerhans cells (LC) are stimulated to leave the and migrate, via afferent lymphatics, draining lymph nodes where they accumulate as immunostimulatory dendritic (DC). It has been demonstrated previously that tumour necrosis factor-alpha (TNF-alpha), an inducible product keratinocytes, interleukin (IL)-1beta, produced exclusively by LC in murine epidermis, provide important signals for initiation this response. Recently, it IL-18,...
Journal Article Tumour necrosis factor alpha is pro‐inflammatory in normal human skin and modulates cutaneous adhesion molecule expression Get access R. W. GROVES, GROVES Dunhill Dermatology Laboratory. St John's Institute, of Dermatology, UMDS, Guy's Hospital, London SEI 9RT, U.K. R.W.Groves, Division Dermatology. Brigham Women's Hospital. 75, Francis Street, Boston, MA 02115. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. H. ALLEN, ALLEN E. L. ROSS, ROSS...
Langerhans cells (LC) migrate rapidly from epidermis to lymph node following epicutaneous application of antigen. In this study, we have explored the role IL-18, a cytokine with structural similarities IL-1 beta, in murine LC migration and contact hypersensitivity (CHS), which oxazolone (OX) 2-4,dinitrofluorobenzene (DNFB) was suppressed significantly IL-18 knockout (IL-18-/-) mice could be rescued by local intradermal administration prior sensitization, suggesting that defect these afferent...