A5052338004- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- Spectroscopy Techniques in Biomedical and Chemical Research
- Tumors and Oncological Cases
- Infectious Diseases and Mycology
- Nail Diseases and Treatments
- Cutaneous lymphoproliferative disorders research
- Hedgehog Signaling Pathway Studies
- Spectroscopy and Chemometric Analyses
- Genetic and rare skin diseases.
- Optical Coherence Tomography Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Ear and Head Tumors
- Photodynamic Therapy Research Studies
- Molecular Biology Techniques and Applications
- Dermatologic Treatments and Research
- Sarcoma Diagnosis and Treatment
- Digital Imaging in Medicine
- Corneal Surgery and Treatments
- Reconstructive Facial Surgery Techniques
- Climate Change and Health Impacts
- Tattoo and Body Piercing Complications
- Salivary Gland Tumors Diagnosis and Treatment
- Ocular Oncology and Treatments
Nottingham University Hospitals NHS Trust
2014-2024
Bombay Hospital
2023
King George's Medical University
2020-2022
University of Nottingham
2007-2020
Queen's Medical Centre
2006-2020
Sri Aurobindo Institute of Medical Sciences
2020
Mid Yorkshire Hospitals NHS Trust
2019
Nottingham Biomedical Research Centre
2019
Sree Gokulam Medical College and Research Foundation
2010-2013
Advanced Dermatology
2013
Background: Photodynamic therapy (PDT) is increasingly used as a noninvasive treatment for nodular basal cell carcinoma (BCC), without sound evidence base.Objective: To compare topical PDT, with the use of sensitizer methyl aminolevulinate, and standard excision surgery in BCC.Design: Prospective, randomized study.Setting: University dermatology departments.Patients: A total 101 adults previously untreated BCC.Interventions: Patients received aminolevulinate PDT (n=52) or (n=49).The was...
Significance Histopathology is the standard method for diagnosis of cancer. However, this requires time-consuming procedures sectioning and staining tissues, making histopathology impractical use during surgery most cancer types. We report a unique based on two optical spectroscopy techniques—autofluorescence imaging Raman scattering—that can accurately measure molecular differences between tumor cells healthy tissue allows tumors faster than histopathology, without requiring or staining....
This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients 114 lesions were treated MAL cream (160 mg/g) applied 3 hours before illumination (570-670 nm, light dose 75 J/cm) (1 session), and 58 105 received (2 freeze-thaw cycles). Patients an incomplete response at months 2 further PDT sessions (n = 20) or repeat 16). 100 93 in...
There are few reports on the role of peritoneal dialysis in critically ill patients requiring continuous renal replacement therapies.Patients with acute kidney injury and multi-organ involvement were randomly allotted to venovenous hemodiafiltration(CVVHDF, group A) or (CPD, B). Cause severity failure assessed at time initiating dialysis. Primary outcome was composite correction uremia, acidosis, fluid overload, hyperkalemia. Secondary outcomes improvement sensorium hemodynamic instability,...
Basal cell carcinoma (BCC) is a common malignancy with good prognosis in the majority of cases. However, some BCC patients develop more advanced disease that poses significant management challenges. Such cases include locally advanced, recurrent or metastatic BCC, tumours occur anatomical sites where surgical treatment would result deformity. Until recently, options for these have been limited, but increased understanding molecular basis has enabled potential therapies, such as hedgehog...
We investigate the potential of Raman microspectroscopy (RMS) for automated evaluation excised skin tissue during Mohs micrographic surgery (MMS). The main aim is to develop an method imaging and diagnosis basal cell carcinoma (BCC) regions. Selected bands responsible largest spectral differences between BCC normal regions linear discriminant analysis (LDA) are used build a multivariate supervised classification model. model based on 329 spectra measured obtained from 20 patients....
A method is presented for acquiring high-spatial-resolution spectral maps, in particular Raman micro-spectroscopy (RMS), by selectively sampling the spatial features of interest and interpolating results. This achieves up to 30 times reduction time compared raster-scanning, resulting images have excellent correlation with conventional histopathological staining, are achieved sufficient signal-to-noise ratio identify individual tissue structures. The benefits this selective not limited...
We describe a multifocal Raman micro-spectroscopy detection method based on digital micromirror device, which allows for simultaneous "power-sharing" acquisition of spectra from ad hoc sampling points.As the locations points can be rapidly updated in real-time via software control liquid-crystal spatial light modulator (LC-SLM), this technique is compatible with automated adaptive-and selective-sampling spectroscopy techniques, latter has previously been demonstrated fast diagnosis skin...
Multimodal spectral imaging (MSI) based on auto-fluorescence and Raman micro-spectroscopy was used to detect basal cell carcinoma (BCC) in tissue specimens excised during Mohs micrographic surgery.In this study, the MSI algorithm optimized maximize diagnosis accuracy while minimizing number of spectra: segmentation images according type BCC, sampling points for spectroscopy were generated intensity variance segment area, additional spectra acquired when performance sub-optimal.The results...
Abstract Background Autofluorescence (AF)–Raman microspectroscopy is a technology that can detect residual basal cell carcinoma (BCC) on the resection margin of fresh, surgically excised tissue specimens. The does not require fixation, staining, labelling or sectioning, and provides quantitative diagnosis maps surgical margins in 30 min. Objectives To determine accuracy AF–Raman instrument detecting incomplete BCC excisions during Mohs micrographic surgery (MMS), using histology as reference...
Multimodal spectral histopathology (MSH), an optical technique combining tissue auto-fluorescence (AF) imaging and Raman micro-spectroscopy (RMS), was previously proposed for detection of residual basal cell carcinoma (BCC) at the surface surgicallyresected skin tissue.Here we report development a fully-automated prototype instrument based on MSH designed to be used in clinic operated by non-specialist spectroscopy user.The algorithms AF image processing classification had been first...
Lentigo maligna (LM) and lentigo melanoma (LMM) can be difficult to manage surgically. Predetermined margins inadequate because of subclinical spread, or affect function when are adjacent the eye mouth.To describe our 5-year experience in Nottingham using staged square procedure (Johnson square) excising facial LM LMM.The is a technique useful for ill-defined lesions that have high recurrence rate due spread. It uses paraffin wax-embedded peripheral vertical sections margin control, ensuring...
### What you need to know A 68 year old woman with skin type 1 presents an 18 month history of a well circumscribed 10 mm erythematous scaly patch over her left shin. Since retirement, she has lived in Spain for part the and now returned UK, worried that increased size. In Bowen’s disease full thickness epidermis is dysplastic atypical keratinocytes, but these have not yet breached basement membrane become squamous cell carcinoma. Reflecting this, also commonly known as carcinoma situ...
We present the first clinical integration of a prototype device based on integrated auto-fluorescence imaging and Raman spectroscopy (Fast device) for intra-operative assessment surgical margins during Mohs micrographic surgery basal cell carcinoma (BCC). Fresh skin specimens from 112 patients were used to optimise tissue pre-processing Fast algorithms enable an analysis complete layers within 30 minutes. The optimisation allowed >95% resection surface area be investigated (including deep...
Abstract Tear gas is used throughout the World for control of riots and civil disobedience. CS as by UK police force issued a ‘spray’ 5% in methylisobutylketone (MIBK), potent irritant. Assaults on officers forces with spray have fallen significantly over past 3 years, whilst having risen areas without it. Thus, appears to be an effective deterrent. However, significant cutaneous reactions can occur result exposure. We report severe contact dermatitis highlight clinical features. The nature...
Telangiectatic leg veins (TLV) are experienced by millions of women and men. As they cause significant cosmetic embarrassment, many seek effective treatment. Options include sclerotherapy treatment with different lasers. We investigated the safety efficacy an 810‐nm diode laser in TLV. Ten females had to a ≥ 25 cm2 area TLV four times at 4‐weekly intervals 25–35 W, 0.1 s duration, 0.5 interval 5‐mm circular spot size (fluence 12.7–17.8 J/cm2). Assessment response was performed 4 weeks after...