A5071151868- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Skin and Cellular Biology Research
- Nail Diseases and Treatments
- Pain Mechanisms and Treatments
- Diagnosis and Treatment of Venous Diseases
- Genetic and rare skin diseases.
- Metabolism and Genetic Disorders
- Dermatological and Skeletal Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Musculoskeletal pain and rehabilitation
- Dermatologic Treatments and Research
- Celiac Disease Research and Management
- Breast Implant and Reconstruction
- Vascular Malformations and Hemangiomas
- Facial Nerve Paralysis Treatment and Research
- Autoimmune and Inflammatory Disorders
- Forest Insect Ecology and Management
- Diabetic Foot Ulcer Assessment and Management
- Trace Elements in Health
- Entomological Studies and Ecology
- Tumors and Oncological Cases
- Vascular Tumors and Angiosarcomas
- Congenital limb and hand anomalies
Churchill Hospital
2004-2022
Oxford University Hospitals NHS Trust
2017
John Radcliffe Hospital
2012
University of Oxford
2008
Basingstoke and North Hampshire Hospital
1997-2002
Slade Hospital
1986-1992
Science Oxford
1991
He Eye Hospital
1989
Plain language summary available online
Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether strategy of starting treatment doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over oral corticosteroids.We did pragmatic, multicentre, parallel-group randomised controlled trial adults bullous (three or more blisters at two sites and linear basement membrane IgG C3). Participants were randomly assigned to (200 mg per day) prednisolone (0·5 mg/kg...
Summary These guidelines have been prepared for dermatologists on behalf of the British Association Dermatologists. They present evidence‐based guidance treatment, with identification strength evidence available at time preparation and a brief overview epidemiological aspects, diagnosis investigation. The reflect data from Medline, Embase, Cochrane library, literature searches experience authors managing patients bullous pemphigoid in special general clinics over 10 years. However, caution...
Patients with bullous pemphigoid were found to have significant ocular abnormalities. In a group of 18 patients one had conjunctival shrinkage, and 11 15 (73%) positive linear direct immunofluorescence on biopsy from clinically uninvolved site. Our findings in 14 cicatricial are also reported compared those control 20. suggest there is overlap between the groups raise further questions about pathogenicity immunoreactants within basement membrane zone. Bulbar was simple well tolerated, rate...
ABSTRACT Six out of 10 patients with chronic wounds suffer from persistent wound pain. A multinational and multicenter randomized double‐blind clinical investigation 122 compared two moist healing dressings: a nonadhesive foam dressing ibuprofen (62 to Biatain Ibu Nonadhesive Coloplast A/S) without (60 Non‐Adhesive—comparator). Patients were recruited September 2005 April 2006. The was considered successful if the pain relief on five‐point Verbal Rating Scale higher than comparator...
Morphoea and keratoconjunctivitis sicca developed in a woman with seronegative rheumatoid arthritis six years after augmentation mammoplasty. Previous reports of post-mammoplasty connective tissue disease have followed the use silicone gel, whereas more 'biologically inert' saline-filled silastic implants were used this case.
Abstract Six out of 10 patients with chronic wounds suffer from persistent wound pain. A multinational and multicentre, randomised, double‐blind clinical investigation 122 compared two moist wound‐healing dressings, a non adhesive foam dressing ibuprofen (62 randomised to Biatain‐Ibu adhesive, Coloplast A/S) without (60 Biatain adhesive).The ibuprofen‐foam was regarded successful, if the pain relief on 5‐point verbal rating scale higher than comparator compromising safety, including...
Journal Article Subcorneal pustular dermatosis followed by pyoderma gangrenosum Get access V.A. Venning, Venning Department of Dermatology, The Slade Hospital, Headington, Oxford OX3 7JH, U.K. Search for other works this author on: Academic Google Scholar T.J. Ryan British Volume 115, Issue 1, 1 July 1986, Pages 117–118, https://doi.org/10.1111/j.1365-2133.1986.tb06229.x Published: 01 1986
The structure of hairs from three patients with sulphur-deficient hair, trichothiodystrophy, has been studied by light, plane-polarizing and scanning electron microscopy. Severe cuticular secondary cortical degeneration was evident along almost the entire length hair shaft, cuticle loss, trichorrhexis nodosa formation trichoschisis. severity these changes varied between patients. role in protecting environmental damage is discussed.
The major bullous pemphigoid (BP) antigen is a 220-240-kDa polypeptide, although some BP sera recognize bands of 180-200 kDa or lower molecular weight. We have investigated to what extent this heterogeneity the target accounts for clinical diversity BP. Immunoblotting studies against extracts salt-separated epidermis were performed on from 39 patients with blotting patters obtained correlated findings, particular reference prodromal itching, lesion morphology and severity, mucosal...
SUMMARY Microsporum canis is the causative organism in less than 10% of all tinea capitis infections UK. Transmission generally via contact with an infected family pet and there are only rare reports case clustering. This article describes outbreak M. a primary school classroom demonstrating human‐to‐human spread from index who was presumed to have acquired infection prior arriving There no suggestion clinical improvement following 4 weeks oral terbinafine 125 mg daily treatment changed...
Summary A 16‐year‐old boy presented with painless swellings localized to the radial and ulnar aspects of his second through fifth fingers on left hand, more subtle changes affecting two opposite hand. This had developed in absence mechanical trauma. Investigations for an arthropathy were negative, while a biopsy showed marked epidermal hyperplasia expanded dermis. These features are typical pachydermodactyly, benign dermatosis uncertain aetiology. The interesting feature this case is...
Good syndrome (GS) is a rare, adult-acquired primary combined immunodeficiency arising in the context of previous or current thymoma. Patients with GS frequently develop recurrent sinopulmonary infections and are also at high risk autoimmune manifestations, including skin conditions such as lichen planus. We report three middle-aged patients complicated by multiple infectious manifestations. The combination immunodeficiency, autoimmunity seen continues to present management challenge,...
The location of in vivo bound immunoreactants was studied 37 patients with subepidermal blistering diseases by direct immunofluorescence (IMF) on suction blisters taken from uninvolved forearm skin. included 18 bullous pemphigoid (BP), nine cicatricial (CP), three acquired epidermolysis bullosa (EBA) and 7 hybrid cases. patterns IMF the were: BP, epidermal 1, dermal combined 4, negative 12; CP, 2, 6; EBA, 1; 'hybrid' patients, 3, 4. different blister staining could not be correlated clinical...
The case is presented of a 29-year-old female who, at the age 13 years, developed bilateral verrucous thickening her areolae. Despite condition causing significant psychosocial morbidity, specialist referral was initially denied on grounds that no treatment apparently available. progressively deteriorated over subsequent 14 years. She eventually referred for dermatology opinion, and diagnosis nevoid hyperkeratosis made. Topical therapy with keratolytics unsuccessful, she plastic surgery...
The distributions in deposition of immunoreactants bullous pemphigoid before and after initiating treatment were investigated. Punch biopsies skin performed on each patient from up to five different sites studied by direct immunofluorescence (DIF). Both groups showed the highest diagnostic yield for DIF perilesional biopsies, with positivity 78% pretreatment group 83% post-treatment group. percentage positive remaining pre-treatment as follows: 50% lower back, 62% oral mucosa, 70% flexor...
Dermatitis herpetiformis (DH) and coeliac disease (CD) are linked but their association with linear IgA dermatosis (LAD) is unclear. Thirty‐seven patients DH 27 were investigated, of which 23/37 1/10 LAD had small intestinal enteropathy. Elevated IgG gliadin antibodies found in the enteropathy (CD). directed against alpha, beta, gamma omega subfractions. adult (n= 14) suggests that this condition may be associated or an diathesis.