A5035726093- Autoimmune Bullous Skin Diseases
- Cytomegalovirus and herpesvirus research
- Dermatology and Skin Diseases
- Herpesvirus Infections and Treatments
- Urticaria and Related Conditions
- Immune Cell Function and Interaction
- Dermatologic Treatments and Research
- HIV Research and Treatment
- Skin and Cellular Biology Research
- Contact Dermatitis and Allergies
- Psoriasis: Treatment and Pathogenesis
- Hair Growth and Disorders
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Genetic and rare skin diseases.
- Medicine and Dermatology Studies History
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hedgehog Signaling Pathway Studies
- Platelet Disorders and Treatments
- Antifungal resistance and susceptibility
- HIV-related health complications and treatments
- Liver Diseases and Immunity
- Virus-based gene therapy research
- Peripheral Neuropathies and Disorders
- Acne and Rosacea Treatments and Effects
Wake Forest University
2024-2025
East Tennessee State University
2024-2025
James Cook University Hospital
2008-2020
Addenbrooke's Hospital
1995-2016
Kiel University
2014
University of Cambridge
1993-2005
Barnsley Hospital
1994-2001
John Radcliffe Hospital
2001
New Cross Hospital
2001
University of the Gambia
1997
Cytotoxic T lymphocytes (CTL) appear to play an important role in the control of human cytomegalovirus (HCMV) normal virus carrier: previous studies have identified peripheral blood CD8+ CTL specific for HCMV major immediate-early gene product (IE1) and more recently, by bulk culture cloning techniques, a structural product, lower matrix protein pp65. In order determine relative contributions which recognize proteins IE1, pp65, glycoprotein B (gB) total HCMV-specific response, we used...
Major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) are part of the cellular immune response to human persistent virus infections. Measurements frequency and specificity immunodeficiency type 1 (HIV-1)-specific CTL their variation with time may indicate relative importance in modulating progression HIV-1 infection. We have used limiting dilution analysis (LDA) derive quantitative estimates HIV-1-specific precursors a cross-sectional study 23 patients at different...
Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether strategy of starting treatment doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over oral corticosteroids.We did pragmatic, multicentre, parallel-group randomised controlled trial adults bullous (three or more blisters at two sites and linear basement membrane IgG C3). Participants were randomly assigned to (200 mg per day) prednisolone (0·5 mg/kg...
Darier's disease (DD) is an autosomal dominant skin disorder characterized clinically by multiple keratotic papules, and histologically focal loss of adhesion between epidermal cells (acantholysis) abnormal keratinization. Variant forms cutaneous phenotype, sometimes familial, have been described. Associated neuropsychiatric features, including mental handicap, schizophrenia, bipolar epilepsy, also reported. The cause DD was shown recently to be mutation in the ATP2A2gene at 12q24.1, which...
Summary The proportion of human peripheral blood CD8 + T cells that are CD57 CD28 – is low at birth but increases with age and in individuals infected cytomegalovirus (HCMV) or immunodeficiency virus (HIV). These contain large oligoclonal T‐cell expansions whose antigen specificity unknown. We identified clonal virus‐specific memory cytotoxic T‐lymphocyte precursors (CTLp) both healthy carriers HCMV asymptomatic HIV‐infected subjects. In each subject, from the receptor (TCR) β‐chain...
This case series and literature review highlights the prevalence of scarring hair loss in children. A retrospective 29 pediatric cases from centers USA Chile showed that primary cicatricial alopecia was more common, with lichen planopilaris central centrifugal being most frequent diagnoses. Early detection children is essential to reduce progressive scarring.
Journal Article Successful treatment of severe recalcitrant psoriasis with combination infliximab and methotrexate Get access B. Kirby, Kirby Dermatology Centre, University Manchester, Hope Hospital, Salford, UK B.Kirby, M6 8HD, UK. Tel.: +44 161 787 4392. Fax: 7871095. E‐mail: bkirby@fs1.ho.man.ac.uk Search for other works by this author on: Oxford Academic Google Scholar A. M. Marsland, Marsland J. Carmichael, Carmichael Department Dermatology, South Cleveland Middlesbrough, C. E....
Journal Article Paraneoplastic pemphigus: an association with fludarabine? Get access C. Gooptu, Gooptu Department of Dermatology, The Oxford Radcliffe Hospital, Oxford, U.K. *Department Haematology, John †Department Ophthalmology, Eye ‡Department South Cleveland Middlesbrough, Departments §Dermatology and ¶Haematology, New Cross Wolverhampton, **Department Keio University, Tokyo, Japan ††Department Kurume Fukuoka, C.Gooptu, St James' University Beckett Street, Leeds LS9 7TF, Search for...
Topical PUVA was compared with UVA for the treatment of chronic vesicular hand eczema in a double-blind randomized within-patient trial. Twelve 15 patients completed 8 weeks' and were followed up weeks. Both sides improved over 8-week period (p less than 0.05) both remained substantially better objectively subjectively at follow-up. There no statistical difference between assessments treated hands any stage. Nine who study answered questionnaire to 18 months later. In 4, healed, 3 on...
Journal Article A case of Schöpf–Schulz–Passarge syndrome Get access P. J. Hampton, Hampton Departments Dermatology and Pathology, Royal Victoria Infirmary, Queen Road, Newcastle upon Tyne, UK Dr Department Dermatology, UK. E‐mail: hamptonpj@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar B. Angus, Angus A. Carmichael The James Cook University Hospital, Middlesbrough, Clinical Experimental Volume 30, Issue 5, 1 September 2005, Pages 528–530,...
SUMMARY Natural killer (NK) cells are an important component of the immediate immune response to infections, including infection by intracellular bacteria. We have investigated recognition Chlamydia trachomatis (CT) NK and show that these activated produce interferon (IFN)-γ when peripheral blood mononuclear (PBMC) stimulated with CT organisms. Furthermore, epithelial cell lines renders them susceptible lysis human cells. Susceptibility was observed 18–24 h following required protein...
17 malades sous hemodialyse periodique et souffrant de prurit grave sont partages en 2 groupes. Chez 10 d'entre eux les dialyses continuees facon identique mais au moyen d'un liquide depourvu magnesium. Ce traitement fait diminuer nettement la magnesiemie, est sans effet sur le amene une augmentation notable l'hormone parathyroidienne, ce qui n'est pas risque