A5078286417- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Celiac Disease Research and Management
- Skin and Cellular Biology Research
- Psoriasis: Treatment and Pathogenesis
- Cellular Mechanics and Interactions
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Nuclear Structure and Function
- Nail Diseases and Treatments
- Telemedicine and Telehealth Implementation
- Wnt/β-catenin signaling in development and cancer
- Immune Cell Function and Interaction
- Microscopic Colitis
- Dermatology and Skin Diseases
- Cystic Fibrosis Research Advances
- Systemic Lupus Erythematosus Research
- Retinoids in leukemia and cellular processes
- Contact Dermatitis and Allergies
- Occupational exposure and asthma
- RNA Research and Splicing
- Parvovirus B19 Infection Studies
- Dermatological and COVID-19 studies
- Platelet Disorders and Treatments
Medical University of Sofia
2017-2025
Alexandrovska Hospital
2020-2024
Sofia University "St. Kliment Ohridski"
2019
Abstract Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or, frequently, generalized bullous lesions. A subset patients only develops excoriations, prurigo‐like lesions, eczematous and/or urticarial erythematous The disease, which significantly associated neurological disorders, has high morbidity severely impacts quality life. Objectives methodology...
Abstract Introduction Dermatitis herpetiformis (DH) is a chronic, pruritic, gluten‐induced skin disorder characterized by subepidermal granular IgA deposition and variable degree of enteropathy identical to that seen in coeliac disease. So far, there has been no European consensus about the management DH. Methods The guidelines were created small subgroups guideline committee consisting 26 specialists from various medical fields one patients’ representative. members then discussed voted for...
Elevated immunoglobulin E (IgE) is a hallmark of allergic diseases. However, high IgE levels also occur in number other infectious and noninfectious In most cases, elevated indicate allergy, eczema, or chronic skin infection. Very are not uncommon patients with active eczema but more often monogenic atopic disorder inborn errors immunity an phenotype. We conducted retrospective study 385 children suspected immune deficiency referred to the clinic over 9-year period. Measurement IgE, IgG,...
Autoimmune blistering diseases of the skin have all been reported in patients with psoriasis, bullous pemphigoid (BP) being most frequently observed. The pathophysiologic triggers for BP psoriatic are unclear. Recent observational studies suggested that chronic inflammation may cause pathological changes to basement membrane zone, thus inducing autoimmunity against antigens through cross reactivity and "epitope spreading." coexistence psoriasis poses challenging therapeutic dilemmas related...
The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an important impact on dermatology practice, posing diagnostic and therapeutic challenges especially in patients with inflammatory autoimmune skin disorders. Disease-specific nonspecific cutaneous manifestations have been increasingly reported the spectrum of but influence infection pre-existing dermatologic diseases not clearly defined. There a debate literature as to whether...
Key Clinical Message High‐dose intravenous immunoglobulin exhibits great potential in the treatment of Netherton syndrome. Abstract syndrome (NS) is a rare autosomal recessive genodermatosis (OMIM #256500) characterized by superficial scaling, atopic manifestations, and multisystemic complications. It caused loss‐of‐function mutations SPINK5 gene, which encode key kallikrein protease inhibitor. There are two subtypes that differ clinical presentation immune profile: ichthyosiform...
Bullous pemphigoid (BP), the by far most frequent autoimmune blistering skin disease (AIBD), is immunopathologically characterized autoantibodies against two hemidesmosomal proteins BP180 (collagen type XVII) and BP230 (BPAG1 or dystonin). Several comorbidities potentially disease-inducing medication have been described in BP, yet a systematic analysis of these clinically relevant findings autoantibody reactivities has not performed.To determine associations with concomitant medication.In...
Pemphigus vulgaris (PV) is an autoimmune bullous dermatosis with uneven geographic distribution and higher incidence in certain populations. In previous studies, a relatively high of PV was reported Bulgaria (0.47/100,000/year) comparable to that other countries. The genetic background considered responsible for the disease susceptibility, multiple reports have proven be HLA-associated condition. aim our study analyze role factors development Bulgaria. HLA genotyping performed 56 patients,...
Limited studies have explored pemphigus variations among different ethnic groups residing in their respective geographical locations. This bicontinental study aimed to compare clinical and immunological parameters Indian European patients complete remission, off therapy, or on minimal therapy. 105 (India, n= 75; Bulgaria, n=15; Greece, n=15) with vulgaris (PV) foliaceous (PF) remission therapy (n=64) (n=41) were recruited. Demographic, clinical, compared. significantly younger, the maximal...
Background and objectives: Dermatitis herpetiformis (DH) is a blistering dermatosis, which shares common immunologic features with celiac disease (CD). The aim of the present study was to explore performance panel CD-related antibodies IL-17A in Bulgarian patients DH. Materials Methods: Serum samples from 26 DH at mean age 53 ± 15 years 20 healthy controls were assessed for anti-tissue transglutaminase (anti-tTG), anti-deamidated gliadin peptides (anti-DGP), anti-actin (AAA), by enzyme...
Food allergy is characterized by an abnormal immune reaction that occurs reproducibly upon exposure to a specific food. This response can lead variety of symptoms, the prevalence food allergies has increased in recent decades, most likely due environmental factors play role expression genetic susceptibility. Recent understanding immunopathogenesis allergic diseases suggested these atopic may be monogenic mutations associated with inborn errors immunity (IEI). Aspects assessed suspected IEI...
Netherton syndrome (NS) is a rare autosomal recessive genodermatosis (OMIM #256500) characterized by superficial scaling, atopic manifestations, and multisystemic complications. It caused loss-of-function mutations in the SPINK5 gene, which encode key kallikrein protease inhibitor. There are two subtypes of that differ clinical presentation immune
Sehr geehrte Herausgeber, Die generalisierte pustulöse Psoriasis (GPP) ist eine relativ seltene und chronische autoinflammatorische Hauterkrankung mit ausgeprägter systemischer Beteiligung.1 Wir stellen den ersten europäischen Patienten vor, der nach offiziellen Zulassung Europäischen Arzneimittelagentur (EMA) für GPP Spesolimab behandelt wurde. beschreiben 34-jährige Frau, die seit September 2022 über Rötungen Schuppenbildung an unteren Extremitäten anschließender Ausbreitung auf Rumpf,...
Abstract Background Dermatitis herpetiformis (DH) is a rare gluten-induced skin disorder characterized predominantly by IgA autoantibodies against endomysium, tissue transglutaminase (TG2/tTG), epidermal (TG3/eTG) and deamidated gliadin. To date, circulating autoantibody reactivity has not been systematically described. Objectives Characterization of serum reactivities in DH. Methods This multicentre international study analysed sera from 242 patients with DH taken at the time initial...