A5043557607- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Reflective Practices in Education
- Innovative Teaching and Learning Methods
- Chemokine receptors and signaling
- Hip and Femur Fractures
- Oral and gingival health research
- Drug-Induced Adverse Reactions
- Skin and Cellular Biology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Dermatology and Skin Diseases
- Educational Practices and Policies
- Dutch Social and Cultural Studies
- Immunotherapy and Immune Responses
- Education and Critical Thinking Development
- Educational and Psychological Assessments
- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Open Education and E-Learning
- Contact Dermatitis and Allergies
- Orthopaedic implants and arthroplasty
- Cancer-related molecular mechanisms research
- Education in Diverse Contexts
- Acute Myeloid Leukemia Research
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
European Clinical Research Infrastructure Network
2024
Noordwest Ziekenhuisgroep
2018-2020
Dialyse Centrum Groningen
2019
Martini Ziekenhuis
2019
University Medical Center Utrecht
2010-2017
University of Amsterdam
2007-2014
The Netherlands Cancer Institute
2006-2011
Vrije Universiteit Amsterdam
2008
Abstract Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of skin and mucous membranes. This typically affects elderly presents with itch localized or, frequently, generalized bullous lesions. A subset patients only develops excoriations, prurigo‐like lesions, eczematous and/or urticarial erythematous The disease, which significantly associated neurological disorders, has high morbidity severely impacts quality life. Objectives methodology...
This guideline has been initiated by the task force Autoimmune Blistering Diseases of European Academy Dermatology and Venereology, including physicians from all relevant disciplines patient organizations. It is a S3 consensus-based that systematically reviewed literature on mucous membrane pemphigoid (MMP) in MEDLINE EMBASE databases until June 2019, with no limitations language. While first part this addressed methodology, as well epidemiology, terminology, aetiology, clinical presentation...
Abstract This guideline on mucous membrane pemphigoid (MMP) has been elaborated by the Task Force for Autoimmune Blistering Diseases of European Academy Dermatology and Venereology (EADV) with a contribution physicians from all relevant disciplines patient organizations. It is S3 consensus‐based encompassing systematic review literature until June 2019 in MEDLINE EMBASE databases. first part covers methodology, clinical definition MMP, epidemiology, MMP subtypes, immunopathological...
Abstract Background Paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare disease with mucocutaneous and multi‐organ involvement. PNP/PAMS typically associated lymphoproliferative or haematological malignancies, less frequently solid malignancies. The mortality rate of elevated owing to the increased risk severe infections disease‐associated complications, such as bronchiolitis obliterans. Objectives These guidelines summarize...
Background: In recent years, many studies have demonstrated the efficacy of an early switch to oral antibiotics after surgical treatment in orthopedic-related infections. However, large analyses on periprosthetic joint infections (PJIs) are lacking. Material and Methods: We conducted a retrospective observational multicenter study patients diagnosed with post-operative PJI, defined as one occurring <3 months index arthroplasty treated debridement, antibiotics, implant retention (DAIR)....
A substantial number of patients with bullous pemphigoid do not develop skin blisters and may have received the correct diagnosis. Diagnostic criteria an optimal diagnostic strategy are needed for early recognition trials.To assess minimal requirements diagnosis nonbullous forms to evaluate strategy.This paired, multivariable, accuracy study analyzed data from 1125 consecutive suspected who were referred Groningen Center Blistering Diseases secondary tertiary care hospitals throughout...
Anti-p200 pemphigoid is a rare subepidermal autoimmune blistering disease characterized by autoantibodies against 200-kDa protein in the basement membrane zone. probably often misdiagnosed because of low availability diagnostic assays and expertise classified as bullous or epidermolysis bullosa acquisita.To clinically characterize patients with anti-p200 pemphigoid, identified using indirect immunofluorescence microscopy on skin substrates deficient type VII collagen laminin-332 (knockout...
Abstract The chemokine receptor CXCR5 is expressed by B cells and certain T controls their migration into within lymph nodes. Its ligand BCA-1/CXCL13 present in nodes spleen also the liver. Surprisingly, we detected several mouse human carcinoma cell lines. was particularly prominent pancreatic lines immunohistochemistry 7 of 18 tissues. Expression CT26 colon low vitro, up-regulated vivo, rapidly lost when were explanted vitro. CXCL13 strongly promoted proliferation CXCR5-transfected In...
The chemokine CXCL12/SDF-1 and its receptor CXCR4 have been implicated in invasion, survival proliferation of carcinoma cells. Recently, CXCR7 was identified as a second for CXCL12. We observed that CXCL12 promoted CT26 colon KEP1 mammary cells, this blocked when downregulated by 'intrakines' or RNAi, but not inhibitors. K1R mutant CXCL12, which acts antagonist, also through is therefore selective agonist. effect due to reduced apoptosis, mediated chemotaxis the cells towards These results...
Abstract Objective To assess the phenotype of reconstituting B cells after cell depletion, and to effect reconstitution on balance Treg effector T in patients with active primary Sjögren's syndrome (SS). Methods Twenty‐eight SS were treated days 1 15 either rituximab (n = 19) or placebo 9). The frequencies absolute numbers circulating subsets, cells, examined fresh blood samples by 4‐color flow cytometry at baseline 5, 12, 24, 36, 48 weeks first infusion. results rituximab‐treated compared...
Background Interest in the role of metacognition has been steadily rising most forms education. This study focuses on construction a questionnaire for measuring metacognitive knowledge, regulation and responsiveness among students higher education subsequent process testing to determine its validity. Purpose The aim was construct an original instrument features metacognition, henceforth referred as Awareness Independent Learning Inventory (AILI), further establish similarities differences...
Abstract Background Non‐bullous pemphigoid (NBP) is a variant which frequently resembles other pruritic skin diseases. In contrast with bullous (BP), blisters are absent. BP, previous studies showed that IgE autoantibodies may be involved in its pathogenesis. IgE‐activated mast cells, basophils and eosinophils participate BP by inducing pruritus possibly blister formation, although the differential role of NBP compared has not yet been described. Objective To assess serum patients. Methods...
An accurate diagnosis of mucous membrane pemphigoid (MMP) is essential to reduce diagnostic and therapeutic delay.To assess the accuracy direct immunofluorescence microscopy on mucosal biopsy specimens immunoserology in a large cohort patients with suspected MMP.This retrospective study was carried out single tertiary care center for blistering diseases between January 2002 March 2019. Eligible participants were MMP paired data at least specimen (DIF) indirect (IIF) human salt-split skin...
The chemokine receptor CXCR6 and its ligand CXCL16 are involved in inflammation. Thus far, they were known to be expressed mainly by T cells macrophages, respectively. However, we detected both all of 170 human primary mammary carcinomas at similar levels 8 carcinoma cell lines tested microarray analysis. Expression was confirmed reverse transcription-PCR for the also fluorescence-activated sorting several mouse mammary, colon, pancreatic lines. is a transmembrane protein from which soluble...
In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing specific brand of canvas shoes.To identify the culprit allergen shoes.Eighteen young females aged 14-22 years presented with itching erythematous to purple-coloured eczematous on both feet. They were patch tested by 10 dermatologists European baseline series. Some underwent testing additional Pieces shoe fabrics 11 18 patients. Chemical analysis materials was performed....
Abstract This study reports on the effects of combined use an interactive whiteboard ( IWB ) and a virtual learning environment VLE mathematics performance motivation. Lessons taught with were made available , so that they could be consulted regardless time place. Students' was monitored during one school year their motivation for followed 3 years. There no relation between frequency being performance. However, students' appeared to positively related combination lessons availability these ....